The contribution of apolipoprotein E alleles on cognitive performance and dynamic neural activity over six decades

Alexander, David; Williams, Leanne M.; Gatt, Justine M.; Dobson‐Stone, Carol; Kuan, S; Todd, Elizabeth; Schofield, Peter R.; Cooper, Nicholas; Gordon, Evian

doi:10.1016/j.biopsycho.2007.03.001

Cited by 135 publications

(102 citation statements)

References 77 publications

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“…The current results, however, contrast with past research suggesting e2 is protective (Chiang et al, 2010;Farrer et al, 1997;Helkala et al, 1996;Lippa et al, 1997;Wilson et al, 2002). The results reported here are based on a small sample of e2 carriers, but contribute to the small number of studies that have explored e2 effects on cognition prior to older-adulthood (Alexander et al, 2007;Alexopoulos et al, 2011). Recent papers have reported differential spatial navigation strategies in e2 carriers in youth (Konishi et al, 2016), as well as altered memory function in individuals diagnosed with post-traumatic stress disorder (Freeman et al, 2005;Johnson et al, 2015;Kim et al, 2013).…”

Section: Discussioncontrasting

confidence: 96%

The APOE paradox: do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline

Lancaster

Tabet

Rusted

2016

Neurobiology of Aging

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Article (Accepted Version) http://sro.sussex.ac.uk Lancaster, Claire, Tabet, Naji and Rusted, Jennifer (2016) The APOE paradox: how do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline. Neurobiology of Aging, This version is available from Sussex Research Online: http://sro.sussex.ac.uk/62415/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. AbstractPossession of an APOE e4 allele is an established risk factor for Alzheimer's disease, while the less commonly studied e2 variant is premised to offer some protection. This research explores the purported deleterious-protective dichotomy of APOE variants on attentional control in mid-adulthood. 66 volunteers, aged 45-55 years, completed three tasks that provided complementary measures of attentional control: prospective memory, sustained attention and inhibition. Performance was compared between e2 carriers, e4 carriers and e3 homozygotes (the population norm). Carriers of the e4 allele showed subtle disadvantages, compared to the e3 group, in accuracy of Stroop task and prospective memory performance. Contrary to expectations, e2 carriers showed performance disadvantages in sustained attention. The finding of detrimental effects in attentional control for both e4 and e2 complicates the current model that proposes opposing effects of these variants on later-life cognition. Future research is needed to understand how cognitive differences develop with increasing age, and the physiological mechanisms that underpin these changes.

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Section: Discussioncontrasting

confidence: 96%

The APOE paradox: do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline

Lancaster

Tabet

Rusted

2016

Neurobiology of Aging

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“…Higher performance on an IQ test was shown for ε4-positive young females in China [47]. Increased verbal fluency across six decades of age span has been reported for ε4-positive subjects [48]. As compared with ε3/ε3 subjects, during a working memory task an ε3/ε4 group displayed greater brain activation in the medial prefrontal and parietal regions bilaterally, and in the right dorsolateral prefrontal cortex during a working memory task [49] While increased brain activation during a task may be an indication that neural systems are less efficient for information processing [50], such an increase could also represent a larger number of cortical resources and involved synapses available for processing incoming information.…”

Section: Paradoxical Increase In Brain Activity and Cognitive Performmentioning

confidence: 80%

APOE ε4 Allele-associated Alzheimer's disease risk is consistent with increased lifetime exposure to a neurotoxic process

Smith¹,

Ashford²

2017

J Syst Integr Neurosci

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“…In order to capture important agerelated information exhaustively in the preliminary study [14] , our findings and discussion are mainly based on the results without multiple comparison correction.…”

Section: F O R E X a M P L E G H E B R E M E D H I N E T A L S H mentioning

confidence: 99%

Apolipoprotein E gene polymorphisms associated with processing speed and executive functions in healthy Han Chinese

Zhang

Ren²,

Li³

et al. 2015

Neurosci. Bull.

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The contribution of apolipoprotein E alleles on cognitive performance and dynamic neural activity over six decades

Cited by 135 publications

References 77 publications

The APOE paradox: do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline

The APOE paradox: do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline

APOE ε4 Allele-associated Alzheimer's disease risk is consistent with increased lifetime exposure to a neurotoxic process

Apolipoprotein E gene polymorphisms associated with processing speed and executive functions in healthy Han Chinese

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