The contribution of alliaceous and cruciferous vegetables to dietary sulphur intake

Doleman, Joanne F.; Grisar, Katrijn; Liedekerke, Lena Van; Saha, Shikha; Roe, Mark; Tapp, Henri S.; Mithen, Richard

doi:10.1016/j.foodchem.2017.04.098

Cited by 32 publications

(13 citation statements)

References 25 publications

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“…Sources of sulfur include inorganic sulfur compounds (e.g., sulfate, SO 4 2− ) and sulfur-containing amino acids (SAAs) such as L-methionine, homocysteine, and cysteine. Protein-rich and alliaceous or cruciferous vegetable-rich diets contain high amounts of sulfur owing to their high content of SAAs and inorganic sulfur compounds, respectively [72]. SAAs are important substrates for the methionine recycling (one-carbon metabolism) and transsulfuration pathways in which sulfate, taurine, and hydrogen sulfide (H 2 S) can be generated through the consecutive actions of the enzymes cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE), 3-mercaptopyruvate sulfurtransferase (3-MST), and cofactors including serine and vitamin B 6 [24,73].…”

Section: Trends Trends In In Molecular Molecular Medicine Medicinementioning

confidence: 99%

Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease

Bourgonje

Feelisch

Faber

et al. 2020

Trends in Molecular Medicine

220

151

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Section: Trends Trends In In Molecular Molecular Medicine Medicinementioning

confidence: 99%

Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease

Bourgonje

Feelisch

Faber

et al. 2020

Trends in Molecular Medicine

220

151

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“…Patients completed a comprehensive 7-d diet diary immediately before the study to assess their habitual diet, and subsequently at 6 and 12 mo. Diet data were analyzed through DietPlan6 (Forestfield Software Ltd, UK) and combined with additional data on the chemical composition of cruciferous and alliaceous vegetables, obtained from analyses of vegetables purchased in retail outlets in the localities of the volunteers, as previously described (16).…”

Section: Methodsmentioning

confidence: 99%

Transcriptional changes in prostate of men on active surveillance after a 12-mo glucoraphanin-rich broccoli intervention—results from the Effect of Sulforaphane on prostate CAncer PrEvention (ESCAPE) randomized controlled trial

Τράκα

Melchini

Coode-Bate

et al. 2019

The American Journal of Clinical Nutrition

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Background Epidemiological evidence suggests that consumption of cruciferous vegetables is associated with reduced risk of prostate cancer progression, largely attributed to the biological activity of glucosinolate degradation products, such as sulforaphane derived from glucoraphanin. Because there are few therapeutic interventions for men on active surveillance for prostate cancer to reduce the risk of cancer progression, dietary approaches are an appealing option for patients. Objective We evaluated whether consumption of a glucoraphanin-rich broccoli soup for 1 y leads to changes in gene expression in prostate tissue of men with localized prostate cancer. Methods Forty-nine men on active surveillance completed a 3-arm parallel randomized double-blinded intervention study for 12 mo and underwent transperineal template biopsy procedures and dietary assessment at the start and end of the study. Patients received a weekly 300 mL portion of soup made from a standard broccoli (control) or from 1 of 2 experimental broccoli genotypes with enhanced concentrations of glucoraphanin, delivering 3 and 7 times that of the control, respectively. Gene expression in tissues from each patient obtained before and after the dietary intervention was quantified by RNA sequencing followed by gene set enrichment analyses. Results In the control arm, there were several hundred changes in gene expression in nonneoplastic tissue during the 12 mo. These were associated with an increase in expression of potentially oncogenic pathways including inflammation processes and epithelial–mesenchymal transition. Changes in gene expression and associated oncogenic pathways were attenuated in men on the glucoraphanin-rich broccoli soup in a dose-dependent manner. Although the study was not powered to assess clinical progression, an inverse association between consumption of cruciferous vegetables and cancer progression was observed. Conclusion Consuming glucoraphanin-rich broccoli soup affected gene expression in the prostate of men on active surveillance, consistent with a reduction in the risk of cancer progression. This trial was registered at clinicaltrials.gov as NCT01950143.

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“…Large amount of cystine is found in animal foods, lentils and seeds (Piste, 2013). Apart from kale, cruciferous vegetables like, cabbages, broccoli and allium vegetables such as onions, leeks and garlic are the best source of this amino acid (Doleman et al, 2017). 4 that the concentration of Glutamic acid in kale ranges from 33.20-450 mg/100 g (Ayaz et al, 2006;Eppendorfer & Bille, 1996;Lisiewska et al, 2008), which is lower than that is found in Hibiscus cannabinus and Haematostaphis barter (Kubmarawa et al, 2009), Korean spinach (Yoon et al, 2016).…”

Section: Amino Acids In Kalementioning

confidence: 99%

Kale: Review on nutritional composition, bio-active compounds, anti-nutritional factors, health beneficial properties and value-added products

Satheesh

Fanta

2020

Cogent Food & Agriculture

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There has been an increasing trend in recent times for taking more of green leafy vegetables (GLV) portion in the human diet. Among various GLVs available for human consumption, some are confined to a specific region and few are available in many parts of the world. Kale (Brassica oleracea L. var. acephala) is among the latter group which belongs to Brassicaceae family. This review summarizes the nutritional composition and anti-nutritional factors of kale available in different parts of the world. Consideration was also given for summarization of the studies reported on health benefits, pharmacological activities and different food products. It is noted from the literature that kale is a good source of fiber and minerals like potassium with higher calcium bioavailability than that of milk. Kale also contains prebiotic carbohydrates, unsaturated fatty acids and different vitamins while the anti-nutritional factors such as oxalates, tannins and phytate are present in higher concentrations. Research studies are reported different health beneficial activities of the kale like protective role in coronary artery disease, Anti-inflammatory activity, Antigenotoxic ability, gastro protective activity, inhibition of the carcinogenic compounds formation, positive to gut microbes, anti-

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The contribution of alliaceous and cruciferous vegetables to dietary sulphur intake

Cited by 32 publications

References 25 publications

Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease

Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease

Transcriptional changes in prostate of men on active surveillance after a 12-mo glucoraphanin-rich broccoli intervention—results from the Effect of Sulforaphane on prostate CAncer PrEvention (ESCAPE) randomized controlled trial

Kale: Review on nutritional composition, bio-active compounds, anti-nutritional factors, health beneficial properties and value-added products

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