Abstract:Background: Hypoxia is a common feature in several respiratory diseases. It is known to impair force generation and increases fatigability of respiratory and peripheral skeletal muscles. The precise mechanisms involved in hypoxia-induced impairment in contractile performance are incompletely understood, but oxidative and nitrosative stress could be at play. Little is known about the effects of hypoxia on the contractility of aged muscles. Aim: To investigate the effect of aging on the contractility of unfatigu… Show more
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