The Continuum of Care: A Paradigm for the Management of Metastatic Colorectal Cancer

Goldberg, Richard M.; Rothenberg, Mace L.; Cutsem, Éric Van; Benson, Al B.; Blanke, Charles D.; Diasio, Robert B.; Grothey, Axel; Lenz, Heinz Josef; Meropol, Neal J.; Ramanathan, Ramesh K.; Becerra, Carlos; Wickham, Rita; Armstrong, Delma; Viele, Carol S.

doi:10.1634/theoncologist.12-1-38

Cited by 217 publications

(172 citation statements)

References 38 publications

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“…The radioactivity was higher in the tumor than in other organs in the control group. A significant difference in the biodistribution of 18 F-FLT in the tumor was observed between the control and cetuximab-treated groups. Biodistributions in the control and cetuximab-treated groups were 0.098±0.005 (%ID/g) x kg and 0.029±0.010 (%ID/g) x kg, respectively (p<0.001).…”

Section: Resultsmentioning

confidence: 91%

“…Biodistribution of 18 F-FLT. The biodistribution of 18 F-FLT in the ex vivo study group on day 3 is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…18 F-FLT was synthesized and obtained from the Hokkaido University Hospital Cyclotron facility. It was synthesized using a modification of a previously published procedure (15).…”

Section: F-flt-pet/ct Studiesmentioning

confidence: 99%

“…The thymidine analog 3'-deoxy-3'-18 F-fluorothymidine ( 18 F-FLT) has been developed as a PET tracer to image proliferation in vivo (10). 18 F-FLT uptake has been shown to reflect the activity of thymidine kinase-1 (TK1), an enzyme expressed during the DNA synthesis phase of the cell cycle. TK1 activity is high in proliferating cells and low in dormant cells.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, this tracer is retained in proliferating cells through the activity of thymidine kinase. Measurement of tumor proliferative activity by 18 F-FLT-PET/CT may be a way to provide an early and accurate assessment of the response to therapy with molecular targeted drugs (12).…”

Section: Introductionmentioning

confidence: 99%

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18F-Fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts

Takeuchi

Kuge

Zhao³

et al. 2011

Oncol Rep

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Abstract. We investigated whether 18 F-fluorothymidinepositron-emission tomography/computed tomography ( 18 F-FLT-PET/CT) is useful for the evaluation of the very early response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab therapy in human lung cancer xenografts. A human tumor xenograft model was established with a human non-small cell lung cancer cell line. The mice were randomly assigned to four groups: tumor growth follow-up, ex vivo study, PET/CT imaging and non-treated control. Mice were administered saline as control or cetuximab on day 1. An immunohistochemical study with Ki-67 was performed. Tumor volume treated with cetuximab was kept significantly smaller than control after day 8, although there was no difference on day 3. On day 3, 18 F-FLT distribution was higher in the tumor than in other tissues, and was significantly decreased by treatment with cetuximab. On PET/CT imaging, 18 F-FLT distribution in the tumor was clearly visualized, and the maximum standardized uptake value (SUV) was significantly decreased after treatment with cetuximab (p<0.01). Ki-67 expression was also significantly decreased on day 3 (p= 0.01). These results suggest that 18 F-FLT-PET/CT can be a useful predictor to determine the response to molecular targeted drugs such as cetuximab at an earlier time point than the change of tumor size.

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Section: Resultsmentioning

confidence: 91%

“…Biodistribution of 18 F-FLT. The biodistribution of 18 F-FLT in the ex vivo study group on day 3 is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…18 F-FLT was synthesized and obtained from the Hokkaido University Hospital Cyclotron facility. It was synthesized using a modification of a previously published procedure (15).…”

Section: F-flt-pet/ct Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations