The Continuous Synthesis of 2-(2'-Hydroxy-5'-Methylphenyl)Benzotriazole over Cu/γ-Al2O3

Advances in synthesis and biological activities of benzotriazole analogues: A micro review

“…Wang, Li and others [64] synthesized 2‐(2′‐hydroxy‐5′‐methylphenyl)benzotriazole (BTA) by the continuous catalytic hydrogenation of NAB to BTZ using a series of hydrogenation catalysts including the transition metal systems like Co/γ‐Al 2 O 3 , Ni/γ‐Al 2 O 3 , Cu/γ‐ Al 2 O 3 (Scheme 37). Among the tested catalytic systems, Cu/γ‐Al 2 O 3 showed excellent catalytic performance with excellent yield (87%) of 2‐(2′‐hydroxy‐5′‐methylphenyl)benzotriazole under optimized reaction conditions.…”

“…Wang, Li and others [64] Very recently, WeipingSu and co-workers achieved [65] a Rh(III)-catalyzed regioselective C-H nitrosation/ annulation reaction of unsymmetrical azobenzenes with [NO][BF 4 ] to obtain various BTZ N-oxides with excellent substrate tolerance and yield (Scheme 38). In addition, the computational investigations revealed that this oxidative C-H functionalization approach engross an attractive redox-neutral Rh(III)/Rh(III) pathway that does not involve the change of Rhodium oxidation state change.…”