The content of glycogenolytic factor in pancreas from different species

Audy, Genevieve; Kerly, Margaret

doi:10.1042/bj0520077

Cited by 20 publications

(6 citation statements)

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“…Before the first pure glucagon was isolated by Staub et al (1953), Audy and Kerly (1952) reported the presence of a glycogenolytic substance in anglerfish islets which was similar to an 'impurity' observed in mammalian insulin preparations.…”

Section: Introductionmentioning

confidence: 99%

Physiology of fish endocrine pancreas

Plisetskaya

1989

Fish Physiol Biochem

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From the very beginning of physiological studies on the endocine pancreas, fish have been used as experimental subjects. Fish insulin was one of the first vertebrate insulins isolated and one of the first insulins whose primary and then tertiary structures were reported. Before a second pancreatic hormone, glucagon, was characterized, a physiologically active 'impurity', similar to that in mammalian insulin preparations, was found in fish insulins.Fish have become the most widely used model for studies of biosynthesis and processing of the pancreatic hormones. It seems inconceivable, therefore, that until the recent past cod and tuna insulins have been the only purified piscine islet hormones available for physiological experiments. The situation has changed remarkably during the last decade.In this review the contemporary status of physiological studies on the fish pancreas is outlined with an emphasis on the following topics: 1) contents of pancreatic peptides in plasma and in islet tissue; 2) actions of piscine pancreatic hormones in fish; 3) specific metabolic consequences of an acute insufficiency of pancreatic peptides; 4) functional interrelations among pancreatic peptides which differ from those of mammals. The pitfalls, lacunae and the perspectives of contemporary physiological studies on fish endocrine pancreas are outlined.

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Section: Introductionmentioning

confidence: 99%

Physiology of fish endocrine pancreas

Plisetskaya

1989

Fish Physiol Biochem

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“…In the year before Staub et al (1953) isolated mammalian glucagon Audy and Kerly (1952) reported glucagon-like activity in angler fish pancreatic extracts. (1869) established several interesting facts.…”

Section: Pancreatic Hormones Insulinmentioning

confidence: 99%

Roots of fish endocrinology, a perspective

Gorbman

1989

Fish Physiol Biochem

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“…107 -109 The chief sources of glucagon are various insulin preparations, although its separation from other materials has been claimed by various authors. 99 " 103 ' 105 - 111 There are three assay methods for glucagon, the two more popular ones being based on the height and duration of the hyperglycemia when injected intravenously into test animals (usually rabbits) or the glycogenolytic action on test liver slices incubated in a proper buffer solution. 100 .…”

Section: Chemistrymentioning

confidence: 99%