The contaminated small bowel syndrome

Isaacs, Peter; Kim, Young S.

doi:10.1016/0002-9343(79)90647-8

Cited by 51 publications

(10 citation statements)

References 57 publications

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“…Although there is no widespread agreement as to which test is preferred for the diagnosis of IBO, the bacteriologic analysis of aspirated jejunal fluid is thought to be the gold standard. 26 Using this method, 23 (50%) of the 46 cirrhotic patients in the present study showed total IBO, caused by gram-negative organisms in 10 cases (22%). These figures compare well with the findings of some investigators, 17,27,28 while they are lower than those reported in other studies.…”

Section: Discussionmentioning

confidence: 56%

Effect of cisapride on intestinal bacterial overgrowth and bacterial translocation in cirrhosis

et al. 2000

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Deranged intestinal motility, which occurs in cirrhosis, may facilitate the development of intestinal bacterial overgrowth (IBO), which can lead to bacterial translocation (BT). To assess the effect of cisapride on IBO and BT in cirrhosis, cirrhotic rats received cisapride or a placebo for 7 days, and measurements of jejunal bacterial content and BT studies were performed. In addition, jejunal fluid from 46 cirrhotic patients was obtained for quantitative bacterial culture. Those patients in whom gram-negative IBO was detected were randomized to receive or not to receive cisapride (20 mg twice per day) for 1 week. Cisapride significantly reduced IBO in cirrhotic rats. In addition, no BT was documented in treated animals, whereas it occurred in 40% in nontreated cirrhotic rats. Total IBO was documented in 23 of 46 cirrhotic patients, which was caused by gram-negative organisms in 10 cases. Orocecal transit time (OCT) significantly decreased after cisapride therapy, and was associated with the abolishment of bacterial overgrowth caused by gram-negative organisms in 4 out of 5 treated patients, whereas it persisted in nontreated cases. Cisapride administration to cirrhotic rats resulted in a reduction of the IBO, which is associated with a marked decrease in BT. On the other hand, cisapride facilitates the abolition of IBO caused by gram-negative organisms in cirrhotic patients. (HEPATOLOGY 2000;31:858-863.)

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Section: Discussionmentioning

confidence: 56%

Effect of cisapride on intestinal bacterial overgrowth and bacterial translocation in cirrhosis

et al. 2000

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“…In vitro sensitivity to commonly used orally absorbed antibiotics showed (table 2) that bacteria isolated from small bowel were more often sensitive to quinolones (ciprofloxacin and norfloxacin) than to tetracycline (39/47 and 34/47 vs 19/47, p < 0.0001 and <0.01, respectively); it is important to note that tetracycline is commonly used to treat chronic diarrhoea and malabsorption associated with bacterial contamination of small bowel [10,11]. There was no difference in sensitivity to ampicillin, erythromycin, co-trimoxazole with that of tetracycline (21/44, 14/22 and 24/47 vs. 19/47, p = ns).…”

Section: Resultsmentioning

confidence: 99%

“…Studies on bacterial population contaminating upper gut and their antibiotic sensitivity pattern from developed countries are sparse [9,10]. Sensitivity of these bacteria to currently available antibiotics has been reported only once [9].…”

Section: Introductionmentioning

confidence: 99%

Spectrum and antibiotic sensitivity of bacteria contaminating the upper gut in patients with malabsorption syndrome from the tropics

Ghoshal

Ranjan

et al. 2003

BMC Gastroenterol

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“…Small intestinal bacterial overgrowth in patients with celiac disease may lead to persistent diarrhea due to disturbances in luminal digestion and alteration of mucosal function, albeit minor [13]. Bacteria in small intestine in patients with SIBO causes deconjugation of bile acids, which causes watery diarrhea due to stimulation of colonic secretion and steatorrhea due to depletion of bile acid pool [13].…”

Section: Discussionmentioning

confidence: 99%

“…Bacteria in small intestine in patients with SIBO causes deconjugation of bile acids, which causes watery diarrhea due to stimulation of colonic secretion and steatorrhea due to depletion of bile acid pool [13]. Lactose intolerance results in persistence of diarrhea mainly due to osmotic effect of unabsorbed lactose and flatulence due to production of gas from fermentation of unabsorbed lactose.…”

Section: Discussionmentioning

confidence: 99%

Partially responsive celiac disease resulting from small intestinal bacterial overgrowth and lactose intolerance

Ghoshal

Misra

et al. 2004

BMC Gastroenterol

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Background: Celiac disease is a common cause of chronic diarrhea and malabsorption syndrome all over the world. Though it was considered uncommon in India in past, it is being described frequently recently. Some patients with celiac disease do not improve despite gluten free diet (GFD). A study described 15 cases of celiac disease unresponsive to GFD in whom small intestinal bacterial overgrowth (SIBO) or lactose intolerance was the cause for unresponsiveness.

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The contaminated small bowel syndrome

Cited by 51 publications

References 57 publications

Effect of cisapride on intestinal bacterial overgrowth and bacterial translocation in cirrhosis

Effect of cisapride on intestinal bacterial overgrowth and bacterial translocation in cirrhosis

Spectrum and antibiotic sensitivity of bacteria contaminating the upper gut in patients with malabsorption syndrome from the tropics

Partially responsive celiac disease resulting from small intestinal bacterial overgrowth and lactose intolerance

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