The construction of fluorophoric thiazolo-[2,3-b]quinazolinone derivatives: a multicomponent domino synthetic approach

Abstract

A library of unique fluorophoric thiazolo[2,3-b]quinazolinones were synthesized under acid catalyzed one pot microwave irradiation technique.

A new class of fluorogenic thiazolo[2,3-b]quinazolinone receptor: selective detection towards mercury and hydrogen bisulfate ions in aqueous medium

“…Taking our previously reported results into consideration, 22 we attempted analogous one pot three component cascade reaction of equimolar mixture of 2-amino thiazole 1, aryl aldehydes 2a-h and cyclic-1,3-dicarbonyls 3a-b under acid mediated microwave heating at 150 °C in a microwave synthesizer. Here also, unexpected formation of a series of compound 5 was achieved in spite of compound 4 ( Scheme 1 ).…”

“…1 ) was also synthesized by previously reported procedure. 22 Fluorescence spectra of benzothiazoloquinazolinone (II) were then measured upon addition of 5 equivalents various metal ions. From the fluorescence spectra, it was observed that no such significant change in emission intensities at 395 nm was occurred after addition of the metal ions (see Fig.…”

“…In continuation of our interest in exploring the synthesis and study of fluorogenic properties of unique thiazolo[2,3- b ]quinazolinones via one-pot cascade reaction under microwave irradiation technique, 22 in this context, we expanded the range of accessible angular –OH functionalized thiazolo[2,3- b ]quinazolinone analogues using 2-amino thiazole precursor. Accumulating evidences towards the formation of thiazolo[2,3- b ]quinazolinones having unique structural arrangement and interesting fluorescence properties, we have investigated the selectivity and sensitivity of HSO 4 − and Hg 2+ ions in aqueous (H 2 O : MeOH, 20 : 80 v/v) medium using this novel receptor.…”

Green and efficient protocol for synthesis a new series of fused pyrimidine derivatives incorporating thioamide moiety

“…cooling then poured in ice-water with stirring followed by filtration of the solid product and watching thoroughly with cold water many times to remove the excess of acids , drying then recrystallized from water (Table 1) Method B ( Mohanta, Pati & Behera, 2020): Equimolar (0.001 mole) of thioamide , dimidone and substituted benzaldehyde were mixed and irradiated under microwave oven at power (700 watt) for (1 min) in presence of (2 % mole)boric acid and (2 drops ) glacial acetic acid. Cooling followed by adding (10ml) of acetone to separate the boric acid then filtration and reduce the filtrate volume to a half by evaporation followed by adding of ice-water with stirring to afford the solid product which then filtrated off, dry followed by recrystallized form water.…”

Molecular Modeling of Novel Fluorophoric Thiazolo- [2, 3-B] Quinazolinones to Study Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Potency

“…A series of thirty-four fluorophoric thiazolo- [2, 3-b] quinazolinone derivatives (5aa, 5ab, …., 5bq) ( Fig. S6 ) was synthesized and characterized by Mohanta et al, (2020) (21). All the ligands were drawn in Chemdraw Ultra 8.0 and were converted into 3D MDL Mol format by using chem3D Ultra 8.0.…”