The construction of a panel of serum amino acids for the identification of early chronic kidney disease patients

Li, Rui; Dai, Jinna; Kang, Hui

doi:10.1002/jcla.22282

Cited by 22 publications

(15 citation statements)

References 28 publications

(56 reference statements)

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“…High levels of serum phenylalanine were observed in the low-risk and high-risk patients compared with the healthy controls, which suggested that phenylalanine may be a potential biomarker for IgA.N. Li et al ( 70 ) reported high levels of serum phenylalanine in patients with renal function impairment; it was suggested that serum amino acid levels may be used for the early detection of CKD. Contradictory to these results, Li et al ( 71 ) detected low levels of serum phenylalanine in patients with lupus nephritis and idiopathic nephrotic syndrome using ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry.…”

Section: Discussionmentioning

confidence: 99%

Network analysis of membranous glomerulonephritis based on metabolomics data

et al. 2018

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Membranous glomerulonephritis (MGN) is one of the most frequent causes of nephrotic syndrome in adults. It is characterized by the thickening of the glomerular basement membrane in the renal tissue. The current diagnosis of MGN is based on renal biopsy and the detection of antibodies to the few podocyte antigens. Due to the limitations of the current diagnostic methods, including invasiveness and the lack of sensitivity of the current biomarkers, there is a requirement to identify more applicable biomarkers. The present study aimed to identify diagnostic metabolites that are involved in the development of the disease using topological features in the component-reaction-enzyme-gene (CREG) network for MGN. Significant differential metabolites in MGN compared with healthy controls were identified using proton nuclear magnetic resonance and gas chromatography-mass spectrometry techniques, and multivariate analysis. The CREG network for MGN was constructed, and metabolites with a high centrality and a striking fold-change in patients, compared with healthy controls, were introduced as putative diagnostic biomarkers. In addition, a protein-protein interaction (PPI) network, which was based on proteins associated with MGN, was built and analyzed using PPI analysis methods, including molecular complex detection and ClueGene Ontology. A total of 26 metabolites were identified as hub nodes in the CREG network, 13 of which had salient centrality and fold-changes: Dopamine, carnosine, fumarate, nicotinamide D-ribonucleotide, adenosine monophosphate, pyridoxal, deoxyguanosine triphosphate, L-citrulline, nicotinamide, phenylalanine, deoxyuridine, tryptamine and succinate. A total of 13 subnetworks were identified using PPI analysis. In total, two of the clusters contained seed proteins (phenylalanine-4-hydroxlylase and cystathionine γ-lyase) that were associated with MGN based on the CREG network. The following biological processes associated with MGN were identified using gene ontology analysis: ‘Pyrimidine-containing compound biosynthetic process’, ‘purine ribonucleoside metabolic process’, ‘nucleoside catabolic process’, ‘ribonucleoside metabolic process’ and ‘aromatic amino acid family metabolic process’. The results of the present study may be helpful in the diagnostic and therapeutic procedures of MGN. However, validation is required in the future.

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Section: Discussionmentioning

confidence: 99%

Network analysis of membranous glomerulonephritis based on metabolomics data

et al. 2018

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“…Serum cystatin C has been proposed as a simple, accurate, and rapid endogenous marker of GFR in research and clinical practice. 12 However, there are conflicting reports regarding the superiority of Cyst C over serum creatinine, with many studies suggesting significant.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Cystatin C, Creatinine, and Blood Urea in Lupus Nephritis Patients with Systemic Lupus Erythematosus: A South Indian Case–Control Study

Yadav¹,

Rani²,

Suleman³

et al. 2021

Indian Journal of Medical Biochemistry

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Lupus nephritis (LN) develops as a result of immunological abnormalities. The pathogenesis of LN is a complex process, involving the deposition of autoantibodies in the glomerulus. The glomerular filtration rate (GFR) is widely accepted as the best overall measure of kidney function, enabling a statement of the complex functions of the kidney in a single numeric expression. The endogenous marker of GFR commonly employed is creatinine, but it does not complete the requirements of an ideal marker because apart from being subjected to tubular secretion it is also influenced by the muscle mass and gender of the patient. Cystatin C is a protein produced by all nucleated cells in the body, freely filtered by glomerulus; neither returned to the bloodstream nor secreted by the renal tubules and also is not influenced by gender or muscle mass. The above features make it a better marker of renal function than creatinine. The medical therapy for LN depends on the severity of the disease. Finding reliable biomarkers for LN will help to evaluate disease activity, identify patients at risk for kidney damage, and facilitate early diagnosis and intervention to improve favorable outcomes.

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“…In recent years, a number of studies suggested the important roles of specific plasmafree amino acids (PFAAs) in the development and progression of a wide variety of human diseases [9,10]. Additionally, there is an increasing number of research works assessing the utility of PFAAs as potential disease biomarkers [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults

Mahbub

Yamaguchi

Nakagami

et al. 2021

JCM

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The published literature on the association of circulatory branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) with reduced kidney function is inconsistent or conflicting. Clarification of it might help to better understand the underlying pathophysiology and to determine potential biomarkers for early detection and evaluation of kidney function decline. Our main purpose was to explore and clarify the potential relationships of individual BCAAs and AAAs with estimated glomerular filtration rate (eGFR) decline. We included the data from 2804 healthy subjects and categorized them into three groups based on eGFR tertiles. The associations between individual amino acids and eGFR were explored by covariate-adjusted logistic regression models. There was a progressive increase in the concentrations of BCAAs and AAAs from the upper to the lower tertiles. We revealed significant positive associations of isoleucine, leucine, and phenylalanine with lower tertiles of eGFR in the adjusted models (p < 0.01–0.001). The findings hold a promising potential of using plasma isoleucine, leucine, and phenylalanine levels for evaluation of kidney function decline. Future longitudinal studies should investigate the causal association between altered levels of these amino acids and impaired kidney function and also the utility of the former as potential biomarkers for evaluating the risk and early detection of the latter.

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The construction of a panel of serum amino acids for the identification of early chronic kidney disease patients

Cited by 22 publications

References 28 publications

Network analysis of membranous glomerulonephritis based on metabolomics data

Network analysis of membranous glomerulonephritis based on metabolomics data

Clinical Significance of Cystatin C, Creatinine, and Blood Urea in Lupus Nephritis Patients with Systemic Lupus Erythematosus: A South Indian Case–Control Study

Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults

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