Within the past two decades or so, the South American region has seen a remarkable rise in the enactment of LGBT (lesbian, gay, bisexual, and transgender) rights-affirming policies. This trend is particularly notable given the dearth of such progress in the rest of the developing world. As such, this study aims to contribute to the small but rapidly growing body of literature on the subject. In particular, I aim to determine which factors are most explanatory of when and why countries will enactLGBT rights policies and why a disparity exists across the region. The first systematic study of its kind, findings suggest that social movements, the language of a state's constitution, and religious trends are most influential in this regard. Noting the limitations of the research, I proceed to suggest possible future research directions.