The constant renewal of the intestinal epithelium in the albino rat

Leblond, C. P.; Stevens, C. E.

doi:10.1002/ar.1091000306

Cited by 538 publications

(171 citation statements)

References 11 publications

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“…Likely because of this, it undergoes intense self-renewal. With its renewal cycle of 4-5 d, it is the fastest proliferating tissue in adult animals (Leblond and Stevens 1948;Clevers 2013). The epithelium of the small intestine ( Fig.…”

Section: Intestinal Crypt Homeostasismentioning

confidence: 99%

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

et al. 2014

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Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven adult stem cell types. Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal enhancers and stem cell growth factors. The Lgr5/R-spondin complex acts by neutralizing Rnf43 and Znrf3, two transmembrane E3 ligases that remove Wnt receptors from the stem cell surface. Rnf43/Znrf3 are themselves encoded by Wnt target genes and constitute a negative Wnt feedback loop. Thus, adult stem cells are controlled by an intricate interplay of potent Wnt agonists, antagonists, and anti-antagonists.

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Section: Intestinal Crypt Homeostasismentioning

confidence: 99%

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

et al. 2014

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“…Elegant clonal marking experiments Lgr5 and Lgr6 markers to study adult stem cell roles M Leushacke and N Barker documented the existence of multipotent adult stem cells within the glandular stomach, but were unable to reveal their identity (Bjerknes and Cheng, 2002). Early studies identified a region just below the pit, termed the isthmus, as the major site of gastric proliferation (Leblond and Stevens, 1948). The subsequent discovery of immature, granule-free cells resembling embryonic stem cells within the isthmus prompted speculation that this region housed the adult stomach stem cells (Karam and Leblond, 1993).…”

Section: Lgr5 As Marker Of Stomach Stem Cellsmentioning

confidence: 99%

Lgr5 and Lgr6 as markers to study adult stem cell roles in self-renewal and cancer

2011

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“…1; Table 2), and that most of the fatty acids are present in phosphatidyl choline (Adams and Heath 1963;Lennox, Lough, and Garton 1968). Endogenous fatty acids may also be derived from microorganisms and desquamated cells, and possibly by direct secretion across the wall of the intestine (Leblond and Stevens 1948;Habel 1959;Burr, McPherson, and Tidwell 1960;Ward, Scott, and Dawson 1964). These sources contributed an average of 3 gjday of faecal fatty acids in sheep with biliary fistulae [Section III(d)].…”

Section: (E) Effect Of Surgery On Absorption Of Fatty Acidsmentioning

confidence: 99%

Dietary and Endogenous Long-Chain Fatty Acids in the Intestine of Sheep, with an Appendix on Their Estimation in Feeds, Bile, and Faeces

Heath¹,

Hill²

1969

Aust. Jnl. Of Bio. Sci.

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SummaryNormal sheep and sheep with fistulae of the bile duct or the thoracic duct were used to provide quantitative information on the movement of fatty acids into and out of the intestine. The operation used to gain access to the thoracic duct did not cause any significant alteration in the absorption of either [14C]tripalmitin injected into the rumen or [14C]palmitic acid injected into the duodenum. Normal sheep absorbed the major fatty acids oleic (92'1±1'3%), palmitic (87·3±5·0%), and stearic acids (93' 3± 1· 4%) with almost equal efficiency, and the absorption of labelled tripalmitin injected into the rumen did not alter as the intake of fatty acids increased from 12g/day (90·1±2·3%) to 44g/day (90·1±1·3%).An average of 6 g of fatty acids entered the duodenum each day in the bile, and an approximately equal amount entered from other endogenous sources. The rate of entry of fatty acids in the bile was increased by secretin and by infusion of bile into the intestine. Sheep deprived of bile absorbed 25± 1· 6% of labelled palmitic acid and slightly less of oleic and stearic acids but the transport of absorbed fatty acids in the lymph was negligible in the absence of bile.

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The constant renewal of the intestinal epithelium in the albino rat

Cited by 538 publications

References 11 publications

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

Lgr5 and Lgr6 as markers to study adult stem cell roles in self-renewal and cancer

Dietary and Endogenous Long-Chain Fatty Acids in the Intestine of Sheep, with an Appendix on Their Estimation in Feeds, Bile, and Faeces

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