Investigation of the deformation characteristics of individual hydrostratigraphic units is the key to construct a regional land subsidence model. All of 12 hydrostratigraphic units in the study area were discussed throughout. On the basis of the measured data of groundwater level, five kinds of changing patterns of groundwater level were deduced and the relationship between the deformation characteristics of aquifer units and the corresponding changing patterns of groundwater level was discussed. The study area is 1.7 10 4 km 2 , where the geological condition is complex. The changing patterns of groundwater level the hydrostratigraphic units have experienced vary from site to site and from time to time. Consequently, the deformation characteristics of units are sophisticated. An identical hydrostratigraphic unit may exhibit different deformation characteristics, such as elasticity, elasto-plasticity, visco-elasticity, and visco-elasto-plasticity, at different sites or during different periods, not to mention the different units. The existing models are difficult to describe the complex visco-elasto-plastic constitutive law under the condition of land subsidence. So the Merchant's model was modified to depict the visco-elasto-plastic behavior of units. Then a three-dimensional flow model with variable parameters and a vertical one-dimensional subsidence model were constructed and coupled. The coupled model was applied in simulating land subsidence in the southern Yangtze Delta and a satisfactory result was obtained. The simulation results show that the new coupled model can depict the complex geological conditions and describe the developing process of land subsidence very well in the southern Yangtze Delta. The new model can surely be used to predict land subsidence in the future, which is very helpful to taking measurements to control land subsidence. regional land subsidence model, deformation characteristics of soil, creep, couple, numerical simulation Land subsidence, which may result from many factors, is a geological hazard that causes ground elevation to decline slowly. Excessive groundwater withdrawal is a main cause for land subsidence. In China, seventeen provinces (cities) have encountered land subsidence due to groundwater withdrawal. The total subsidence area has reached 90000 km 2 , which has resulted in huge economic loss. In order to control land subsidence effecttively and reduce the damage, and to ensure the safety of high-speed highway and railway, and the sustainable development and reasonable planning, it is currently in urgent need to solve the problem of constructing a regional land subsidence model to predict the developing trend of land subsidence. The cones of depression and the bowls of subsidence have joined together, thus a regional land subsidence often involves an area of 10000 30000 km 2 or more. The previous land subsidence models in China and other countries often covered dozens of or one to two hundred square kilometers and included only one or two hydrostratigraphic units with