The consolidation of neuroleptic therapy: Janssen, the discovery of haloperidol and its introduction into clinical practice

López-Muñoz, Francisco; Álamo, Cecilio

doi:10.1016/j.brainresbull.2009.01.005

Cited by 76 publications

(58 citation statements)

References 30 publications

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“…Recently, the neurogenic hypothesis of depression was established after the demonstration that serotonin depletion inhibited adult neurogenesis [17], and that chronic but not acute antidepressant treatment increased SGZ proliferation and neurogenesis [18]. In addition, a number of studies demonstrated the relationship between the hippocampus, stress, monoamines and major depressive disorder [19][20][21]. Consequently, adult neurogenesis has been postulated as a key factor modulating emotional processes like stress, depression or anxiety.…”

Section: Introductionmentioning

confidence: 98%

The postnatal origin of adult neural stem cells and the effects of glucocorticoids on their genesis

Ortega-Martínez

Trejo

2015

Behavioural Brain Research

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Section: Introductionmentioning

confidence: 98%

The postnatal origin of adult neural stem cells and the effects of glucocorticoids on their genesis

Ortega-Martínez

Trejo

2015

Behavioural Brain Research

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“…Haloperidol was among the first antipsychotics and was widely hailed as a breakthrough upon its introduction in the 1950s (Lopez-Munoz and Alamo, 2009). Since then, haloperidol has been used extensively in psychiatry and its effectiveness is well established (Adams et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Neurochemical Metabolomics Reveals Disruption to Sphingolipid Metabolism Following Chronic Haloperidol Administration

McClay

Vunck

Batman

et al. 2015

J Neuroimmune Pharmacol

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Haloperidol is an effective antipsychotic drug for treatment of schizophrenia, but prolonged use can lead to debilitating side effects. To better understand the effects of long-term administration, we measured global metabolic changes in mouse brain following 3 mg/kg/day haloperidol for 28 days. These conditions lead to movement-related side effects in mice akin to those observed in patients after prolonged use. Brain tissue was collected following microwave tissue fixation to arrest metabolism and extracted metabolites were assessed using both liquid and gas chromatography mass spectrometry (MS). Over 300 unique compounds were identified across MS platforms. Haloperidol was found to be present in all test samples and not in controls, indicating experimental validity. Twenty-one compounds differed significantly between test and control groups at the p < 0.05 level. Top compounds were robust to analytical method, also being identified via partial least squares discriminant analysis. Four compounds (sphinganine, N-acetylornithine, leucine and adenosine diphosphate) survived correction for multiple testing in a non-parametric analysis using false discovery rate threshold < 0.1. Pathway analysis of nominally significant compounds (p < 0.05) revealed significant findings for sphingolipid metabolism (p = 0.02) and protein biosynthesis (p = 0.03). Altered sphingolipid metabolism is suggestive of disruptions to myelin. This interpretation is supported by our observation of elevated N-acetylaspartylglutamate in the haloperidol-treated mice (p = 0.004), a marker previously associated with demyelination. This study further demonstrates the utility of murine neurochemical metabolomics as a method to advance understanding of CNS drug effects.

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“…The so-called "psychopharmacological revolution," in the context of treating schizophrenic patients, began in the 1950s with the clinical introduction of chlorpromazine [3][4][5] and haloperidol [6] . These drugs dramatically influenced the management of patients with schizophrenia: they modified the course of psychosis made possible a new care organization, with a reduction in the number of patients admitted in health institutions and in days of hospitalization.…”

Section: Introductionmentioning

confidence: 99%

A Bibliometric Analysis of Scientific Research on Atypical Antipsychotic Drugs in India during 1998-2013

López‐Muñoz¹,

Srinivasan

Gutiérrez-Soriano

et al. 2016

Mol Med Chem

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Background:We carried out a bibliometric study on the scientific publications on atypical antipsychotic drugs (AADs) from India. Methods: Using the EMBASE and MEDLINE databases, we performed the selection of documents produced in India. We applied bibliometric indicators of production and dispersion, namely Price's law on the increase of scientific literature and Bradford's law, respectively. We also calculated the participation index (PI) of different countries. The bibliometric data have also been correlated with relevant social and health data from India (including total per capita expenditure on health and gross domestic expenditure on research and development). Results: In this study, we identified 639 original documents published between 1998 and 2013 from India. Our results indicated fulfilment of Price's law (correlation coefficient r = 0.9619 after exponential adjustment vs. r = 0.9382 after linear adjustment). The most widely studied AADs were olanzapine (173 documents), clozapine (117), risperidone (100) and quetiapine (65). Publications appeared in 221 different journals, with only 4 of the top 10 journals having an impact factor greater than 2. Division into Bradford zones yielded a nucleus occupied by the Indian Journal of Psychiatry (53 articles). It is remarkable that the 27.38% of the production is devoted to "medical/pharmaceutical chemistry" field. India has the largest ratio PI AAD / PI Psychiatry and Neurology in the world's 12 most productive countries in biomedicine and health sciences. Conclusions: The publications on AADs in India have undergone exponential growth over the studied period, without evidence of reaching a saturation point.

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The consolidation of neuroleptic therapy: Janssen, the discovery of haloperidol and its introduction into clinical practice

Cited by 76 publications

References 30 publications

The postnatal origin of adult neural stem cells and the effects of glucocorticoids on their genesis

The postnatal origin of adult neural stem cells and the effects of glucocorticoids on their genesis

Neurochemical Metabolomics Reveals Disruption to Sphingolipid Metabolism Following Chronic Haloperidol Administration

A Bibliometric Analysis of Scientific Research on Atypical Antipsychotic Drugs in India during 1998-2013

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