2007
DOI: 10.1016/j.jmb.2007.02.045
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The Conserved Active Site Proline Determines the Reducing Power of Staphylococcus aureus Thioredoxin

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Cited by 69 publications
(83 citation statements)
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“…These results are analogous to the calculations with a model of wild type Trx, and thus within the structural environment of wild type Trx, Trp28 has no effect on reactivity, regioselectivity and on the pKa of Cys29 Trx . As such, the experimentally obtained results 5,6 of an increased pKa of Cys29 Trx and a decreased redox potential in Trx W28A most likely originates form the structural effects induced by the partial unfolding of Trx W28A.…”
Section: Resultsmentioning
confidence: 92%
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“…These results are analogous to the calculations with a model of wild type Trx, and thus within the structural environment of wild type Trx, Trp28 has no effect on reactivity, regioselectivity and on the pKa of Cys29 Trx . As such, the experimentally obtained results 5,6 of an increased pKa of Cys29 Trx and a decreased redox potential in Trx W28A most likely originates form the structural effects induced by the partial unfolding of Trx W28A.…”
Section: Resultsmentioning
confidence: 92%
“…6 They seem to be partially unfolded, reminiscent to a molten globule-like population. 6 We previously showed that the pKa of Cys29 increases from 7.1 in wild type Trx to 8.3 in the monomeric form of Trx W28A, 5 which is a pKa value more similar to the pKa of a cysteine out of its structural environment. Further, in Trx W28A, the redox potential decreases from À268 mV to À284 mV.…”
Section: Introductionmentioning
confidence: 97%
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