The consequences of particle uptake on immune cells

Sharma, Preeti; Alakesh, Alakesh; Jhunjhunwala, Siddharth

doi:10.1016/j.tips.2022.01.009

Cited by 7 publications

(5 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As shown in Fig. S1 4b and c, cells treated with LDC exhibited higher fluorescence intensity than those treated with free DOX (P < 0.001), and the average fluorescence intensity of LDC in MCF-7 cells was 4.13 times that of DOX at 4 h and reached 4.58 times at 24 h. The mechanism underlying the increased uptake of LDC compared with DOX is that nanoparticles could be internalized by cells through endocytosis, whereas free drugs could only permeate the cells through passive diffusion [52]. Furthermore, positively charged COS coated on the surface of LDC could also improve the cellular uptake of LDC [53].…”

Section: In Vitro Cytotoxicity and Cellular Uptake Studiesmentioning

confidence: 96%

Tumor-microenvironment double-responsive shrinkable nanoparticles fabricated via facile assembly of laponite with a bioactive oligosaccharide for anticancer therapy

Zhong

Wang

Jiang

et al. 2023

Journal of Drug Delivery Science and Technology

View full text Add to dashboard Cite

Section: In Vitro Cytotoxicity and Cellular Uptake Studiesmentioning

confidence: 96%

Tumor-microenvironment double-responsive shrinkable nanoparticles fabricated via facile assembly of laponite with a bioactive oligosaccharide for anticancer therapy

Zhong

Wang

Jiang

et al. 2023

Journal of Drug Delivery Science and Technology

View full text Add to dashboard Cite

“…And positively charged nanoparticles accumulate to a greater extent in macrophages than negatively charged particles [ 81 , 82 ]. However, in addition to dosage, surface charge, especially positive charge, may be the most critical particle property in determining cytotoxicity [ 83 ].…”

Section: Drug Loading Of Macrophagesmentioning

confidence: 99%

Macrophage based drug delivery: Key challenges and strategies

Guo,

Qian

2024

Bioactive Materials

View full text Add to dashboard Cite

“…Particle uptake and overload of phagocytes and potential ways to boost this process for clinical applications have been investigated (e.g. Lehnert, 1990; Pacheco, White & Sulchek, 2013; Sharma et al ., 2020; Sharma, Alakesh & Jhunjhunwala, 2022). In the mammalian lung, Morrow (1988) observed that phagocytic impairment of the AMs begins when the volume of the phagocytosed particles reaches 6% of the normal volume of the phagocyte and that further particle uptake ceases when the volume density of the phagocytosed particles reaches 60% of the cell volume.…”

Section: Phagocytic Cells Involved In the Defence Of The Avian Lungmentioning

confidence: 99%

A critical assessment of the cellular defences of the avian respiratory system: are birds in general and poultry in particular relatively more susceptible to pulmonary infections/afflictions?

Maina

2023

Biological Reviews

View full text Add to dashboard Cite

In commercial poultry farming, respiratory diseases cause high morbidities and mortalities, begetting colossal economic losses. Without empirical evidence, early observations led to the supposition that birds in general, and poultry in particular, have weak innate and adaptive pulmonary defences and are therefore highly susceptible to injury by pathogens. Recent findings have, however, shown that birds possess notably efficient pulmonary defences that include: (i) a structurally complex three‐tiered airway arrangement with aerodynamically intricate air‐flow dynamics that provide efficient filtration of inhaled air; (ii) a specialised airway mucosal lining that comprises air‐filtering (ciliated) cells and various resident phagocytic cells such as surface and tissue macrophages, dendritic cells and lymphocytes; (iii) an exceptionally efficient mucociliary escalator system that efficiently removes trapped foreign agents; (iv) phagocytotic atrial and infundibular epithelial cells; (v) phagocytically competent surface macrophages that destroy pathogens and injurious particulates; (vi) pulmonary intravascular macrophages that protect the lung from the vascular side; and (vii) proficiently phagocytic pulmonary extravasated erythrocytes. Additionally, the avian respiratory system rapidly translocates phagocytic cells onto the respiratory surface, ostensibly from the subepithelial space and the circulatory system: the mobilised cells complement the surface macrophages in destroying foreign agents. Further studies are needed to determine whether the posited weak defence of the avian respiratory system is a global avian feature or is exclusive to poultry. This review argues that any inadequacies of pulmonary defences in poultry may have derived from exacting genetic manipulation(s) for traits such as rapid weight gain from efficient conversion of food into meat and eggs and the harsh environmental conditions and severe husbandry operations in modern poultry farming. To reduce pulmonary diseases and their severity, greater effort must be directed at establishment of optimal poultry housing conditions and use of more humane husbandry practices.

show abstract

The consequences of particle uptake on immune cells

Cited by 7 publications

References 95 publications

Tumor-microenvironment double-responsive shrinkable nanoparticles fabricated via facile assembly of laponite with a bioactive oligosaccharide for anticancer therapy

Tumor-microenvironment double-responsive shrinkable nanoparticles fabricated via facile assembly of laponite with a bioactive oligosaccharide for anticancer therapy

Macrophage based drug delivery: Key challenges and strategies

A critical assessment of the cellular defences of the avian respiratory system: are birds in general and poultry in particular relatively more susceptible to pulmonary infections/afflictions?

Contact Info

Product

Resources

About