The consequence of cerebral small vessel disease: Linking brain atrophy to motor impairment in the elderly

Su, Ning; Liang, Xinyu; Zhai, Feifei; Zhou, Lixin; Ni, Jun; Yao, Ming; Tian, Feng; Zhang, Shuyang; Jin, Zhengyu; Cui, Liying; Gong, Gaolang; Zhu, Yi-Cheng

doi:10.1002/hbm.24284

Cited by 32 publications

(23 citation statements)

References 46 publications

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“…Compared to HCs, both of the WMH groups exhibited volumetric loss of deep subcortical GM nuclei, especially the bilateral thalamus, in line with previous studies focused on subcortical vascular MCI patients [12] or patients with high WMH load from a community-dwelling cohort [43]. Furthermore, to extend their findings, we found that the WMH-MCI patients showed a more widespread and severe reduction of thalamic GMV than the WMH-nCI patients and further identified positive correlations between several subregions of the thalamus and cognition (processing speed and executive function) within the WMH-MCI group.…”

Section: Discussionsupporting

confidence: 89%

Cortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities and Subsequent Cognitive Impairment

et al. 2021

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Grey matter (GM) alterations may contribute to cognitive decline in individuals with white matter hyperintensities (WMH) but no consensus has yet emerged. Here, we investigated cortical thickness and grey matter volume in 23 WMH patients with mild cognitive impairment (WMH-MCI), 43 WMH patients without cognitive impairment, and 55 healthy controls. Both WMH groups showed GM atrophy in the bilateral thalamus, fronto-insular cortices, and several parietal-temporal regions, and the WMH-MCI group showed more extensive and severe GM atrophy. The GM atrophy in the thalamus and fronto-insular cortices was associated with cognitive decline in the WMH-MCI patients and may mediate the relationship between WMH and cognition in WMH patients. Furthermore, the main results were well replicated in an independent dataset from the Alzheimer's Disease Neuroimaging Initiative database and in other control analyses. These comprehensive results provide robust evidence of specific GM alterations underlying WMH and subsequent cognitive impairment.

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Section: Discussionsupporting

confidence: 89%

Cortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities and Subsequent Cognitive Impairment

et al. 2021

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“…Motor performance was quantified using standard motor scales, which have been described elsewhere 26 , 40 . The lower-extremity function was evaluated via 3-m walking speed and 5-repeat chair-stand time.…”

Section: Methodsmentioning

confidence: 99%

Disrupted white matter integrity and network connectivity are related to poor motor performance

Zhai

Liu

et al. 2020

Sci Rep

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Motor impairment is common in the elderly population. Disrupted white matter tracts and the resultant loss of connectivity between cortical regions play an essential role in motor control. Using diffusion tensor imaging (DTI), we investigated the effect of white matter microstructure on upper-extremity and lower-extremity motor function in a community-based sample. A total of 766 participants (57.3 ± 9.2 years) completed the assessment of motor performance, including 3-m walking speed, 5-repeat chair-stand time, 10-repeat hand pronation-supination time, and 10-repeat finger-tapping time. Fractional anisotropy (FA), mean diffusivity (MD), and structural network connectivity parameters were calculated based on DTI. Lower FA and higher MD were associated with poor performance in walking, chair-stand, hand pronation-supination, and finger-tapping tests, independent of the presence of lacunes, white matter hyperintensities volume, and brain atrophy. Reduced network density, network strength, and global efficiency related to slower hand pronation-supination and finger-tapping, but not related to walking speed and chair-stand time. Disrupted white matter integrity and reduced cerebral network connectivity were associated with poor motor performance. Diffusion-based methods provide a more in-depth insight into the neural basis of motor dysfunction.

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“…However, subcortical syndromes, such as gait disorders, tend to be neglected because of their insidious onset. Certainly, not all individuals with CSVD eventually experience gait disturbances, although CSVD has been recognized as a possible cause of gait impairment (Su et al, 2018 ). In other words, the motor impairments associated with CSVD cannot be fully interpreted by WMHs or LAs on MRI.…”

Section: Introductionmentioning

confidence: 99%

Altered Brain Function in Cerebral Small Vessel Disease Patients With Gait Disorders: A Resting-State Functional MRI Study

Zhou

Zhang

et al. 2020

Front. Aging Neurosci.

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Gait disturbances are important clinical features of cerebral small vessel disease (CSVD) that increase the risk of falls and disability. Brain structural alterations and gait disturbances in CSVD patients have been well demonstrated. However, intrinsic resting cerebral function patterns in CSVD patients with gait disorders remain largely unknown. Fifty-eight CSVD patients were enrolled in our studies and categorized into the gait disorder group (CSVD-GD, n = 29) and no-gait disorder group (CSVD-NGD, n = 29) based on a gait examination. Gait was quantitatively assessed with the Timed Up and Go test and the intelligent device for energy expenditure and activity (IDEEA). Functional MRI and fractional amplitude of low-frequency fluctuation (fALFF) analyses were employed to explore local intrinsic neural oscillation alterations. Functional connectivity based on fALFF results was calculated to detect the potential changes in remote connectivity. Compared with the CSVD-NGD group, the CSVD-GD group showed decreased fALFF in regions mainly located in the sensorimotor network and frontoparietal network, such as the left supplementary motor area (SMA.L) and the left superior parietal gyrus, and increased fALFF in the right inferior frontal gyrus (orbital part), the left caudate, and the left precuneus. Moreover, the CSVD-GD patients exhibited lower connectivity between the SMA.L and temporal lobe, which was related to gait speed. The fALFF value of the SMA.L was associated with cadence. This study highlights the regional and network interaction abnormalities of the SMA in CSVD patients with gait disturbances. These findings could provide further insight into the neural mechanisms of gait disturbances in CSVD.

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The consequence of cerebral small vessel disease: Linking brain atrophy to motor impairment in the elderly

Cited by 32 publications

References 46 publications

Cortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities and Subsequent Cognitive Impairment

Cortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities and Subsequent Cognitive Impairment

Disrupted white matter integrity and network connectivity are related to poor motor performance

Altered Brain Function in Cerebral Small Vessel Disease Patients With Gait Disorders: A Resting-State Functional MRI Study

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