The connectivity signature of co-speech gesture integration: The superior temporal sulcus modulates connectivity between areas related to visual gesture and auditory speech processing

Straube, Benjamin; Wroblewski, Adrian; Jansen, Andreas; He, Yifei

doi:10.1016/j.neuroimage.2018.07.037

Cited by 18 publications

(17 citation statements)

References 58 publications

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“…We employed a content judgement paradigm from previous studies from our research group to investigate modality-specific processing of social/non-social information (He et al, 2015; Straube et al, 2013b; Straube et al, 2018). Of note, the same fMRI dataset has been published with an unrelated research question (Wroblewski et al, 2020).…”

Section: Methodsmentioning

confidence: 99%

“…We performed statistical whole-brain analysis in a two-level, mixed-effects procedure. On the first level, single-participant BOLD responses were modeled by a design matrix comprising the onset time points of each event (critical word of each sentence as used in the previous event-related fMRI and EEG studies, e.g., (He et al, 2015; He et al, 2018a; He et al, 2018c; Straube et al, 2013b; Straube et al, 2018)), with a duration of 5s for all experimental conditions. The micro-time onset was set to the average time bin (8 of 16) to align the onset vector to the slice in the middle of the brain.…”

Section: Methodsmentioning

confidence: 99%

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Modality-specific dysfunctional neural processing of social-abstract and non-social-concrete information in schizophrenia

Steines

Sammer

et al. 2020

Preprint

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Background: Schizophrenia (SZ) is characterized by marked social dysfunctions encompassing potential deficits in the processing of social and non-social information, especially in everyday settings where multiple modalities are present. To date, the neurobiological basis of these deficits remains elusive.Methods: In a functional magnetic resonance imaging (fMRI) study, 17 patients with schizophrenia or schizoaffective disorder, and 18 matched controls watched videos of an actor speaking, gesturing (unimodal), and both speaking and gesturing (bimodal) about social or non-social events in a naturalistic way. Participants had to judge whether each video contains person-related (social) or object-related (non-social) information.Results: When processing social content, controls activated the medial prefrontal cortex (mPFC) for both speech and gesture conditions; patients, in comparison to controls, showed no different activation in the speech condition but reduced activation in the mPFC in the gesture condition. For non-social content, across modalities, controls recruited the bilateral pre/postcentral gyrus, superior temporal gyrus, and insula, as well as the left occipitotemporal cortex; patients showed reduced activation of the left postcentral gyrus and the right insula only in the speech condition. Moreover, in the bimodal conditions, patients displayed improved task performance and comparable activation to controls in both social and non-social content. Conclusions:Patients with SZ displayed modality-specific aberrant neural processing of social and non-social information, which is not present for the bimodal conditions. This finding provides novel insights into dysfunctional social cognition in SZ, and may have potential therapeutic implications.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Modality-specific dysfunctional neural processing of social-abstract and non-social-concrete information in schizophrenia

Steines

Sammer

et al. 2020

Preprint

Self Cite

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“… 62–65 The STG mediates connectivity between other regions in speech-gesture integration. 66 In our previous fMRI gesture performance task, healthy controls had stronger activation in left STG than patients during gesture planning. However, there was no association between gesture performance and neural activity in the STG.…”

Section: Discussionmentioning

confidence: 83%

Dysbalanced Resting-State Functional Connectivity Within the Praxis Network Is Linked to Gesture Deficits in Schizophrenia

Wüthrich

Viher

Stegmayer

et al. 2020

Schizophrenia Bulletin

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Abstract Patients with schizophrenia frequently present deficits in gesture production and interpretation, greatly affecting their communication skills. As these gesture deficits can be found early in the course of illness and as they can predict later outcomes, exploring their neural basis may lead to a better understanding of schizophrenia. While gesturing has been reported to rely on a left lateralized network of brain regions, termed praxis network, in healthy subjects and lesioned patients, studies in patients with schizophrenia are sparse. It is currently unclear whether within-network connectivity at rest is linked to gesture deficit. Here, we compared the functional connectivity between regions of the praxis network at rest between 46 patients and 44 healthy controls. All participants completed a validated test of hand gesture performance before resting-state functional magnetic resonance imaging (fMRI) was acquired. Patients performed gestures poorer than controls in all categories and domains. In patients, we also found significantly higher resting-state functional connectivity between left precentral gyrus and bilateral superior and inferior parietal lobule. Likewise, patients had higher connectivity from right precentral gyrus to left inferior and bilateral superior parietal lobule (SPL). In contrast, they exhibited lower connectivity between bilateral superior temporal gyrus (STG). Connectivity between right precentral gyrus and left SPL, as well as connectivity between bilateral STG, correlated with gesture performance in healthy controls. We failed to detect similar correlations in patients. We suggest that altered resting-state functional connectivity within the praxis network perturbs correct gesture planning in patients, reflecting the gesture deficit often seen in schizophrenia.

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“…These findings provide further support for studies that have suggested that the decrease of structural connectivity at resting state in the occipital cortex impacts social development [Jung et al, 2017; Di Martino et al, 2014; Libero et al, 2014]. Moreover, the social brain areas associated with the connectivity of the OL‐TL regions are the Superior Temporal Sulcus (STS), Wernicke's area, and the visual cortex, which are responsible for multisensory integration of information [Spivey, Joanisse, & McRae, 2012; Straube, Wroblewski, Jansen, & He, 2018]. Wernicke's area, located in the left temporal lobe of most individuals, is implicated in sematic processing of language, speech articulation, and auditory perception [Spivey et al, 2012].…”

Section: Discussionmentioning

confidence: 99%

Changes in Electroencephalogram Coherence in Adolescents With Autism Spectrum Disorder After a Social Skills Intervention

et al. 2021

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Autism spectrum disorder (ASD) is a developmental condition that affects social communication and behavior. There is consensus that neurological differences are present in ASD. Further, theories emphasize the mixture of hypo‐ and hyper‐connectivity as a neuropathologies in ASD [O'Reilly, Lewis, & Elsabbagh, 2017]; however, there is a paucity of studies specifically testing neurological underpinnings as predictors of success on social skills interventions. This study examined functional neural connectivity (electroencephalogram [EEG], coherence) of adolescents with ASD before and after the Program for the Education and Enrichment of Relational Skills (PEERS®) intervention, using a randomized controlled trial of two groups: an Experimental ASD (EXP) Group and a Waitlist Control ASD (WL) Group. The study had two purposes. First, the study aimed to determine whether changes in EEG coherence differed for adolescents that received PEERS® versus those that did not receive PEERS®. Results revealed a significant increase in connectivity in the occipital left to temporal left pair for the EXP group after intervention. Second, the study aimed to determine if changes in EEG coherence related to changes in behavior, friendships, and social skills measured by questionnaires. At post‐intervention, results indicated: (a) positive change in frontal right to parietal right coherence was linked to an increase in social skills scores; and (b) positive changes in occipital right to temporal right coherence and occipital left to parietal left coherence were linked to an increase in the total number of get‐togethers. Results of this study support utilizing neurobehavioral domains as indicators of treatment outcome. Lay Summary: This study examined how well various areas of the brain communicate in adolescents with ASD before and after a social skills intervention. Results revealed increased connectivity in the adolescents that received the intervention. Secondly, the study aimed to determine if changes in connectivity of brain areas related to changes in behavior, friendships, and social skills. Results indicated that changes in connectivity were also linked to increased social skills. Autism Res 2021, 14: 787–803. © 2021 International Society for Autism Research and Wiley Periodicals LLC

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The connectivity signature of co-speech gesture integration: The superior temporal sulcus modulates connectivity between areas related to visual gesture and auditory speech processing

Cited by 18 publications

References 58 publications

Modality-specific dysfunctional neural processing of social-abstract and non-social-concrete information in schizophrenia

Modality-specific dysfunctional neural processing of social-abstract and non-social-concrete information in schizophrenia

Dysbalanced Resting-State Functional Connectivity Within the Praxis Network Is Linked to Gesture Deficits in Schizophrenia

Changes in Electroencephalogram Coherence in Adolescents With Autism Spectrum Disorder After a Social Skills Intervention

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