The Connection between the Endometrial Thickness and the Risk of Endometrial Malignancy in Postmenopausal Women

Abstract

BACKGROUND: Postmenopausis is a period that starts one year after the last menstruation. Late menopause, after 70 years, is called senile.
 AIM: To examine the correlation between endometrial thickness and the risk of endometrial malignancy in postmenopausal.
 MATERIAL AND METHODS: Prospective clinical study involving 120 postmenopausal patients treated at the University Clinic for Gynecology and Obstetrics – Skopje, divided into two groups: control and examination. The control group included 40 postmenopausal patients, hospitalised and operated due to urogenital pathology. The examined group consisted of 80 patients divided into three subgroups according to the ultrasound verified thickness of the endometrium: from 5-8 mm; > 8-11 mm and above 11 mm. A detailed history and intervention were taken in the patients from both groups, and the material was sent for histopathological analysis to determine eventual malignancy.
 RESULTS: The probability of endometrial malignancy significantly increased by 1.012 times in the group with a thickness of the endometrium from 5-8 mm, 1.769 times in the endometrial thickness group > 8-11 mm and 4.737-fold in the group over 11 mm compared to the control group.
 CONCLUSION: In postmenopausal patients, the likelihood of endometrial cancer significantly increases with the thickness of the endometrium.

Relationship between the Metabolic Associated Fatty Liver Disease and Endometrial Thickness in Postmenopausal Women: A Cross-sectional Study in China

“…The postmenopausal women were divided into three groups: (1) the postmenopausal women with ET of <3 mm (2) the postmenopausal women with ET of 3 mm ≤ & < 5 mm and (3) the postmenopausal women with ET of ≥ 5 mm (the cutoff threshold for ET has been used in previous studies [20][21][22][23][24]). Statistical analysis was performed with Microsoft Excel 2013, SPSS 23.0, and R software in this study.…”

“…Postmenopausal women who underwent annual pelvic ultrasound screening are the most important detection method for endometrial cancer. ET over 5 mm was most likely to be defined as endometrial thickening [20][21][22][23][24] and study shows that the risk of endometrial cancer and endometrial hyperplasia with atypia in asymptomatic postmenopausal women is increased with ET ≥ 11 mm [25]. ET of postmenopausal women is related to endometrial disease-related carcinoma [26,27].…”

Prognostic Factors for Early-Stage Endometrial Cancer Management in Fertile Patients

“…More specifically, ET measurements over 15mm has a fivefold increase in EC risk. When ET is over 20mm, this risk increases by 20 times more than the risk in general population [32]. In premenopausal patients who undergo selective estrogen receptor modulators therapy when endometrial thickness <15mm endometrial hyperplasia is less likely to occur [33].…”