The connection between the breast and heart in a woman: Breast cancer and cardiovascular disease

Gulati, Martha; Mulvagh, Sharon L.

doi:10.1002/clc.22886

Cited by 58 publications

(42 citation statements)

References 45 publications

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“…O câncer de mama está associado ao aumento de problemas cardiovasculares decorrentes, principalmente, do tratamento oncológico e, quanto mais avançado for o diagnóstico do câncer de mama, mais agressivos serão os tratamentos e, consequentemente, maior o risco de complicações cardiovasculares. Nesse sentido, conhecer a prevalência de doenças cardiovasculares e seus fatores de risco ao diagnóstico de câncer de mama é fundamental para direcionar os tratamentos oncológicos [24][25][26] .…”

Section: Discussionunclassified

Qualidade de Vida Relacionada à Saúde e Risco de Comorbidade Cardiovascular ao Diagnóstico de Câncer de Mama

Aguiar

Rodrigues

Santos

et al. 2019

Rev. Brasileira.De.Cancerologia

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Introdução: A literatura sugere que mulheres com doenças cardiovasculares apresentam pior qualidade de vida ao diagnóstico de câncer de mama. Objetivo: Avaliar a associação entre a qualidade de vida relacionada à saúde (QVRS) e as doenças cardiovasculares ao diagnóstico de câncer de mama. Método: Estudo transversal com mulheres diagnosticadas com câncer de mama. A QVRS foi avaliada pelos questionários European Organization for Research and Treatment of Cancer Quality of Life Questionnarie (EORTC QLQ-C30) and Breast Câncer Module (QLQ-BR23) e a comorbidade por meio da Cumulative Illness Rating Scale Geriatric (CIRS-G). Foram calculadas as diferenças entre as médias dos escores de QVRS e comorbidade. A associação foi avaliada por regressão logística múltipla. Resultados: Foram incluídas 953 mulheres com média de idade de 54 anos (DP±11,7). Apresentavam alguma comorbidade ao diagnóstico de câncer de mama 84,1% das mulheres. O sistema coração foi afetado em 10,8% e o sistema vascular em 48,2%. Após ajuste, observou-se associação entre os escores das funções física e sexual e problemas nos sistemas coração e vascular. Foi ainda observada associação entre os piores escores de dor e dispneia e o sistema coração. Em relação à presença de doenças no sistema vascular, este esteve associado à melhor satisfação sexual, melhor perspectiva futura e piores sintomas na mama. Conclusão: A QVRS se mostrou associada a doenças cardiovasculares em pacientes com câncer de mama em relação à função física, sexual, satisfação sexual, perspectivas futuras e as escalas de sintomas (dor, dispneia e sintomas na mama).

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Section: Discussionunclassified

Qualidade de Vida Relacionada à Saúde e Risco de Comorbidade Cardiovascular ao Diagnóstico de Câncer de Mama

Aguiar

Rodrigues

Santos

et al. 2019

Rev. Brasileira.De.Cancerologia

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“…Cardiovascular disease is the leading cause of death in women in general and among breast cancer survivors in particular [1,2]. Among breast cancer survivors aged fifty and more, deaths due to cardiovascular disease account for 35% of non-cancer related deaths [1]. Cardiovascular disease is the leading cause of death in patients with breast cancer over fifty years of age [3].…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Disease among Breast Cancer Survivors

Majeed¹,

Ayyala²,

Kapuku³

et al. 2020

CDM

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Background: Among breast cancer survivors age > 50 years, deaths due to cardiovascular disease account for 35% of non-cancer related deaths. The increases in cardiovascular disease among breast cancer survivors is due to the cardiotoxic effects of breast cancer treatment and to overlapping risk factors for breast cancer and cardiovascular disease. Methods: We conducted a study of a sample of 164 breast cancer patients in order to examine the frequency of cardiovascular disease. The overall objective was to examine the frequency of high blood pressure, myocardial infarction, cardiomyopathy, congestive heart failure, stroke, and venous thrombosis/thromboembolism among women who have been diagnosed with stage I-IV breast cancer and who had completed primary therapy for the disease. Data were collected by postal survey and abstraction of electronic medical records. Results: A high percentage of the women (62.8%) had a reported history of high blood pressure. Fifty percent of the women had a reported history of high cholesterol. About 8.3% of the women were current smokers and 36.0% were former smokers. About 23.8% of the women had a reported history of diabetes. About 4.9% of the women had a reported history of congestive heart failure and 6.1% had a history of stroke. Discussion: Additional studies are needed of cardiovascular risk factors and adverse cardiovascular events among breast cancer survivors. Of particular concern is whether patients with hypertension, hypercholesterolemia, and diabetes are receiving appropriate therapy to reduce their cardiovascular risk and prevent morbidity and mortality from adverse cardiovascular events.

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“…BC and CVD are associated, with high level of evidence supporting inflammation as unifying risk factor of both conditions sharing the similar casual pathways. In fact, chronic inflammatory condition is associated with oxidative stress, so a number of predictors of NCD associated with inflammation and oxidative stress, such as diabetics, obesity, dyslipidemia, and different type of malignancies, may play a role in the complex effect on BC risk of recurrence and therapy related side effects 7,9 . Furthermore, there is an evidence-based link between BC and postmenopausal status with obesity, making the latter a consistent predictor for both conditions 9 .…”

mentioning

confidence: 99%

“…In fact, chronic inflammatory condition is associated with oxidative stress, so a number of predictors of NCD associated with inflammation and oxidative stress, such as diabetics, obesity, dyslipidemia, and different type of malignancies, may play a role in the complex effect on BC risk of recurrence and therapy related side effects 7,9 . Furthermore, there is an evidence-based link between BC and postmenopausal status with obesity, making the latter a consistent predictor for both conditions 9 . This is the case for hyperlipidemia, which is a known risk factor for atherosclerosis, whereas low-density lipoprotein (LDL) was suggested to be associated with development of cancer subtypes including BC 9 .…”

mentioning

confidence: 99%

“…Furthermore, there is an evidence-based link between BC and postmenopausal status with obesity, making the latter a consistent predictor for both conditions 9 . This is the case for hyperlipidemia, which is a known risk factor for atherosclerosis, whereas low-density lipoprotein (LDL) was suggested to be associated with development of cancer subtypes including BC 9 . Lewis et al, (2017) found that BRCA1 and BRCA2 gene mutations may contribute in preservation of cardiovascular system function, and these gene abnormalities are associated with elevated risk of CVD in BC patients receiving anthracycline-based therapy 10 .…”

mentioning

confidence: 99%

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Meta-regression analysis of the effect of lifestyle interventions on mediators of inflammation in postmenopausal breast cancer women with cardiovascular risk factors

Milambo

Kotze

Rajiv

et al. 2019

Preprint

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Background: Chronic inflammation is associated with obesity, dyslipidemia, and different types of malignancies that may play a complex role in the risk of breast cancer (BC) recurrence and therapy related side effects. The purpose of this review was to determine the effects of lifestyle interventions on mediators of inflammation (C-reactive protein (CRP), interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α)) and other therapy related adverse events in postmenopausal BCS with cardiovascular related risk factors. Methods: A systematic search for relevant articles was performed according to the Preferred Reporting Items for Systematic Review and Meta-Analysis criteria using available databases (PubMed, Scopus, The Cochrane Library, OpenGrey, Google Scholar and CENTRAL). Results: Twelve eligible randomized controlled trials (RCT) met the inclusion criteria. The mean ages of postmenopausal BC women ranged from 49 to 56 years. The meta-regression revealed that there was moderate evidence that MSE decreased the mean difference (MD) of inflammatory markers in BCS, with CVD risk factors (MD: 0.31; 95% CI: 0.05 to 0.57, P=0.02; heterogeneity: Tau² = 0. 12; Chi² = 106.30, df = 19, I² = 0. 50.4%). Conclusion: There is a moderate level of evidence on the effects of MSE on mediators of inflammation in postmenopausal BCS with cardiovascular risk factors. A number of shared risk factors between postmenopausal status and CVD should be considered, while treating postmenopausal BCS.

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The connection between the breast and heart in a woman: Breast cancer and cardiovascular disease

Cited by 58 publications

References 45 publications

Qualidade de Vida Relacionada à Saúde e Risco de Comorbidade Cardiovascular ao Diagnóstico de Câncer de Mama

Qualidade de Vida Relacionada à Saúde e Risco de Comorbidade Cardiovascular ao Diagnóstico de Câncer de Mama

Cardiovascular Disease among Breast Cancer Survivors

Meta-regression analysis of the effect of lifestyle interventions on mediators of inflammation in postmenopausal breast cancer women with cardiovascular risk factors

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