The conformation of chloramphenicol in the ordered and disordered phases

Abstract

The cooperative O-H•••O-H interactions in crystalline CHL reveal its actual conformation.Melting involves the reversal of the intramolecular hydrogen bonds.The Conformation of Chloramphenicol in the ordered and disordered phases.

Amorphous solid dispersions in poly(ε-caprolactone)/xanthohumol bioactive blends: physicochemical and mechanical characterization

“…The observed red shift (~32 cm -1 ) is larger than those reported for blends of PCL with thymol [44] or chloramphenicol [60] (~25 cm -1 ) indicating stronger hydrogen bonding interactions. for pure completely dry XH, about 3300 cm -1 [61] indicates the occurrence of cooperative [60], though the actual location observed can be affected by residual water or other compounds that may cocrystallize with the pure compound [62], [63]. As can be seen, the addition of PCL to XH shifts the band to higher wavenumbers, up to about 3350 cm -1 as the PCL content in the blend increases.…”

“…As can be seen, blending with XH results in the occurrence of a new band located at about 1703 cm -1 , attributable to hydrogen bonded C=O groups in PCL [34]. The observed red shift (~32 cm -1 ) is larger than those reported for blends of PCL with thymol [44] or chloramphenicol [60] (~25 cm -1 ) indicating stronger hydrogen bonding interactions. for pure completely dry XH, about 3300 cm -1 [61] indicates the occurrence of cooperative [60], though the actual location observed can be affected by residual water or other compounds that may cocrystallize with the pure compound [62], [63].…”

Benefits of Polydopamine as Particle/Matrix Interface in Polylactide/PD-BaSO4 Scaffolds

“…A higher proliferation of HDFs was observed in PLA/BaSO 4 or PLA/PD-BaSO 4 composites with respect to pristine PLA samples. Is hypothesized that this higher proliferation rate may be associated to surface characteristic of the samples, such as roughness or hydrophilicity [ 35 , 36 ]…”

“…A higher proliferation of HDFs was observed in PLA/BaSO 4 or PLA/PD-BaSO 4 composites with respect to pristine PLA samples. Is hypothesized that this higher proliferation rate may be associated to surface characteristic of the samples, such as roughness or hydrophilicity [35,36] DNA content observed at day 7 and that observed at day 1 for all the samples studied. For example, the calculated proliferation rates between day 1 and day 7 were 1.6, 3.2 and 2.4 for PLA, PLA/BaSO4 and PLA/PD-BaSO4, respectively.…”

“…A higher proliferation of HDFs was observed in PLA/BaSO4 or PLA/PD-BaSO4 composites with respect to pristine PLA samples. Is hypothesized that this higher proliferation rate may be associated to surface characteristic of the samples, such as roughness or hydrophilicity [35,36] Concurrently, PD coating of BaSO4 particles introduced binding sites for biologically active molecules such as proteins or drugs, increasing the use of this composite in second-generation devices for biomedical applications.…”