The conducted vascular response as a mediator of hypercapnic cerebrovascular reactivity: A modelling study

Daher, Ali; Payne, Stephen

doi:10.1016/j.compbiomed.2024.107985

Computers in Biology and Medicine

2024

DOI: 10.1016/j.compbiomed.2024.107985

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The conducted vascular response as a mediator of hypercapnic cerebrovascular reactivity: A modelling study

Ali Daher,

Stephen Payne

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Time-domain methods for quantifying dynamic cerebral blood flow autoregulation: Review and recommendations. A white paper from the Cerebrovascular Research Network (CARNet)

Kostoglou,

Bello-Robles,

Brassard

et al. 2024

J Cereb Blood Flow Metab

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Cerebral Autoregulation (CA) is an important physiological mechanism stabilizing cerebral blood flow (CBF) in response to changes in cerebral perfusion pressure (CPP). By maintaining an adequate, relatively constant supply of blood flow, CA plays a critical role in brain function. Quantifying CA under different physiological and pathological states is crucial for understanding its implications. This knowledge may serve as a foundation for informed clinical decision-making, particularly in cases where CA may become impaired. The quantification of CA functionality typically involves constructing models that capture the relationship between CPP (or arterial blood pressure) and experimental measures of CBF. Besides describing normal CA function, these models provide a means to detect possible deviations from the latter. In this context, a recent white paper from the Cerebrovascular Research Network focused on Transfer Function Analysis (TFA), which obtains frequency domain estimates of dynamic CA. In the present paper, we consider the use of time-domain techniques as an alternative approach. Due to their increased flexibility, time-domain methods enable the mitigation of measurement/physiological noise and the incorporation of nonlinearities and time variations in CA dynamics. Here, we provide practical recommendations and guidelines to support researchers and clinicians in effectively utilizing these techniques to study CA.

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Time-domain methods for quantifying dynamic cerebral blood flow autoregulation: Review and recommendations. A white paper from the Cerebrovascular Research Network (CARNet)

Kostoglou,

Bello-Robles,

Brassard

et al. 2024

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

show abstract

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The conducted vascular response as a mediator of hypercapnic cerebrovascular reactivity: A modelling study

Cited by 1 publication

References 131 publications

Time-domain methods for quantifying dynamic cerebral blood flow autoregulation: Review and recommendations. A white paper from the Cerebrovascular Research Network (CARNet)

Time-domain methods for quantifying dynamic cerebral blood flow autoregulation: Review and recommendations. A white paper from the Cerebrovascular Research Network (CARNet)

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