Abstract:In many organisms, mRNA transcription must be globally repressed in germline precursor cells during specification for them to maintain a germline fate. In C. elegans, germline precursor cells are known as the P lineage, and it is the PIE-1 protein that is responsible for silencing transcription in these cells. Loss of PIE-1 results in a fate switch, whereby the P2 cell loses germline fate and instead adopts a somatic fate. Previous work had also defined a global chromatin compaction (GCC) pathway that silences… Show more
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