The Concomitance of Hypertension and Diabetes Exacerbating Retinopathy: The Role of Inflammation and Oxidative Stress.

Duarte, Diego Andreazzi; Silva, Kamila C.; Rosales, Mariana A. B.; Faria, José B. Lopes de; Faria, Jacqueline M. Lopes de

doi:10.2174/1574884711308040002

Cited by 14 publications

(8 citation statements)

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“…The present model of simultaneous type 2 diabetes and renal hypertension was associated with increased SBP. The model was also associated with increased index of oxidative stress, erythrocyte SOD activity, and increased index of lipid peroxidation, which have been reported in similar [10] or other models [21] of type 2 diabetes.…”

Section: Isolated Aortic Studysupporting

confidence: 77%

Effects of oleuropein in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms

Nekooeian

Khalili

Khosravi

2014

Journal of Asian Natural Products Research

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The mechanism of oleuropein's antihypertensive effects was examined in rat model of simultaneous type 2 diabetes and renal hypertension (diabetic hypertensive). Five groups of male Sprague-Dawley rats including a control, a diabetic-hypertensive group receiving vehicle, and three diabetic-hypertensive groups receiving oleuropein at 20, 40, or 60 mg/kg/day were used. The duration of diabetes was 10 weeks; during the last 4 weeks of which, animals were hypertensive and received vehicle or oleuropein. Systolic blood pressure, glucose and malondialdehyde, heart rate, and maximal response to phenylephrine (PE) in the absence of nitro-L-arginine methyl ester (L-NAME) of oleuropein-treated groups were significantly lower than those of vehicle-treated group. Erythrocyte superoxide dismutase, maximal response to PE in the presence of L-NAME, and maximal response to acetylcholine (Ach) of oleuropein-treated groups were significantly higher than those of vehicle-treated group. The findings indicate that antihypertensive effects of oleuropein might be partly mediated by improving the release of nitric oxide, and antioxidant and sympathoplegic activities.

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Section: Isolated Aortic Studysupporting

confidence: 77%

Effects of oleuropein in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms

Nekooeian

Khalili

Khosravi

2014

Journal of Asian Natural Products Research

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“…NFkBIA, NFkB1, COX2, MYD88, and IRAK1) are cyclically activated by NFkB. The imbalance between NFkB and IkB has several consequences, such as hyper-inflammation and loss of cell repair and function, which lead to apoptosis and DR disease evolution (Duarte et al 2013). …”

Section: Role Of Oxidative Stress and Inflammation In The Developmentmentioning

confidence: 99%

Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy

Elahy¹,

Baindur-Hudson²,

Cruzat³

et al. 2014

Journal of Endocrinology

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Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation, and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR), which is the major cause of blindness in young diabetic adults. PEDF plays a protective role in DR and there is accumulating evidence of the neuroprotective effect of PEDF. In this paper, we review the role of PEDF and the mechanisms involved in its antioxidative, anti-inflammatory, and neuroprotective properties.

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“…However, the link between oxidative stress and inflammatory processes is inconclusive, requiring more mechanistic studies that highlight the interaction between these processes and how they affect diabetes, HTN, and when HTN is found in the presence of T2DM. 5 , 6 …”

Section: Introductionmentioning

confidence: 99%

Inflammation and oxidative stress markers in diabetes and hypertension

Pouvreau¹,

A²,

Butkowski³

et al. 2018

JIR

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BackgroundInflammation and oxidative stress are important factors associated with chronic disease such as essential hypertension (HTN) and type 2 diabetes mellitus (T2DM). However, the association of inflammation and oxidative stress in HTN with T2DM as a comorbidity is inconclusive due to the multifactorial nature of these cardiometabolic diseases.MethodologyThe influence of pathophysiological factors include genetics, age of patient, and disease progression change throughout the lifespan and require further investigation. The study population included 256 participants attending a rural health screening program who were tested for markers of inflammation, oxidative stress, and coagulation/fibrinolysis. Demographic and clinical variables included, age, gender, systolic and diastolic blood pressures, blood glucose, hemoglobin A1c, estimated glomerular filtration rate, and cholesterol profile. Data were tested for normality, and nonparametric statistics were applied to analyze the sample with significance set at p<0.05.ResultsOf the inflammatory markers, interleukin-1β (IL-1β) and IL-10 were significantly different between the control and hypertensive group (p<0.03) and between the HTN+T2DM compared to the HTN group (p<0.05). Significant results for oxidative stress were observed for urinary 8-iso-PGF2α and insulin-like growth factor 1 (IGF-1) between the control and the HTN+T2DM group (p<0.01). Glutathione (GSH) was also significant between the HTN and HTN+T2DM group (p<0.05). Investigation of the progression of HTN also found significant changes in the inflammatory markers IGF-1, monocyte chemoattractant protein 1 (MCP-1), and (MCP-1/IGF-1)*IL-6 (p<0.05).ConclusionThis study demonstrated that 8-iso-PGF2α and erythrocyte GSH may be clinically useful for assessing HTN and HTN with T2DM as a comorbidity, while significant changes in the inflammatory profile were also observed with HTN progression.

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The Concomitance of Hypertension and Diabetes Exacerbating Retinopathy: The Role of Inflammation and Oxidative Stress.

Cited by 14 publications

References 0 publications

Effects of oleuropein in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms

Effects of oleuropein in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms

Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy

Inflammation and oxidative stress markers in diabetes and hypertension

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