The conceptual design of a hybrid life support system based on the evaluation and comparison of terrestrial testbeds

Czupalla, Markus; Horneck, G.; Blome, Hans Joachim

doi:10.1016/j.asr.2005.06.010

Cited by 34 publications

(11 citation statements)

References 57 publications

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“…In recent years, extensive researches have been carried out on this issue by USA, Russia, Japan, and Europe (Barstev et al, 1996;Drysdale et al, 2002;Ashida, 2003;Czupalla et al, 2005). Studies on the requirements towards space animals feeding to provide edible animal protein have been conducted (Manukovsky et al, 2005;Czupalla et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Silkworms culture as a source of protein for humans in space

Yang¹,

Tang²,

Tong³

et al. 2009

Advances in Space Research

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Section: Introductionmentioning

confidence: 99%

Silkworms culture as a source of protein for humans in space

Yang¹,

Tang²,

Tong³

et al. 2009

Advances in Space Research

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“…Exposure to ionizing radiation (IR), specifically high-energy protons ( 1 H) and ions with high charge and high energy (HZE particles), is one of the major risks during spaceflight beyond low Earth orbit (LEO) ( 1 , 2 ). For example, astronauts on future Mars missions are expected to encounter ~0.6 Sv of IR during 180 days transit to Mars ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Ionizing Particle Radiation as a Modulator of Endogenous Bone Marrow Cell Reprogramming: Implications for Hematological Cancers

et al. 2015

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Exposure of individuals to ionizing radiation (IR), as in the case of astronauts exploring space or radiotherapy cancer patients, increases their risk of developing secondary cancers and other health-related problems. Bone marrow (BM), the site in the body where hematopoietic stem cell (HSC) self-renewal and differentiation to mature blood cells occurs, is extremely sensitive to low-dose IR, including irradiation by high-charge and high-energy particles. Low-dose IR induces DNA damage and persistent oxidative stress in the BM hematopoietic cells. Inefficient DNA repair processes in HSC and early hematopoietic progenitors can lead to an accumulation of mutations whereas long-lasting oxidative stress can impair hematopoiesis itself, thereby causing long-term damage to hematopoietic cells in the BM niche. We report here that low-dose 1H- and 56Fe-IR significantly decreased the hematopoietic early and late multipotent progenitor (E- and L-MPP, respectively) cell numbers in mouse BM over a period of up to 10 months after exposure. Both 1H- and 56Fe-IR increased the expression of pluripotent stem cell markers Sox2, Nanog, and Oct4 in L-MPPs and 10 months post-IR exposure. We postulate that low doses of 1H- and 56Fe-IR may induce endogenous cellular reprogramming of BM hematopoietic progenitor cells to assume a more primitive pluripotent phenotype and that IR-induced oxidative DNA damage may lead to mutations in these BM progenitors. This could then be propagated to successive cell lineages. Persistent impairment of BM progenitor cell populations can disrupt hematopoietic homeostasis and lead to hematologic disorders, and these findings warrant further mechanistic studies into the effects of low-dose IR on the functional capacity of BM-derived hematopoietic cells including their self-renewal and pluripotency.

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“…Up to date diverse artificial ecosystems are elaborated (Tamponnet et al, 1993;Hirafuji et al, 2001;Godia et al, 2002;Allen et al, 2003;Tikhomirov et al, 2003;Sychev et al, 2003;Czupalla et al, 2004;Rodriguez et al, 2004), and both the models and experience to explore them could be used for life support on the Moon. Some of them anticipate use of microorganisms for purposively cultivating plants (Holland, 2000;Gros et al, 2003;Roberts et al, 2004).…”

Section: Introductionmentioning

confidence: 98%