The concept of ocular inserts as drug delivery systems: An overview

Deivasigamani, Karthikeyan; Bhowmick, Mithun; Pandey, VijayPrakesh; Nandhakumar, J; Sengottuvelu, S.; Sonkar, Sandeep Kumar; Sivakumar, T.

doi:10.4103/0973-8398.45031

Cited by 34 publications

(17 citation statements)

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“…In comparison to contact lenses and eye drops, the use of collagen shields enabled obtaining higher drug concentration in the cornea and the aqueous humor [4, 30]. …”

Section: Topical Ophthalmic Drug Formsmentioning

confidence: 99%

Ophthalmic Drug Dosage Forms: Characterisation and Research Methods

Baranowski

Karolewicz

Gajda

et al. 2014

The Scientific World Journal

217

122

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This paper describes hitherto developed drug forms for topical ocular administration, that is, eye drops, ointments, in situ gels, inserts, multicompartment drug delivery systems, and ophthalmic drug forms with bioadhesive properties. Heretofore, many studies have demonstrated that new and more complex ophthalmic drug forms exhibit advantage over traditional ones and are able to increase the bioavailability of the active substance by, among others, reducing the susceptibility of drug forms to defense mechanisms of the human eye, extending contact time of drug with the cornea, increasing the penetration through the complex anatomical structure of the eye, and providing controlled release of drugs into the eye tissues, which allows reducing the drug application frequency. The rest of the paper describes recommended in vitro and in vivo studies to be performed for various ophthalmic drugs forms in order to assess whether the form is acceptable from the perspective of desired properties and patient's compliance.

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“…In comparison to contact lenses and eye drops, the use of collagen shields enabled obtaining higher drug concentration in the cornea and the aqueous humor [4, 30]. …”

Section: Topical Ophthalmic Drug Formsmentioning

confidence: 99%

Ophthalmic Drug Dosage Forms: Characterisation and Research Methods

Baranowski

Karolewicz

Gajda

et al. 2014

The Scientific World Journal

217

122

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“…If the inserts is formed of the solid non-erodible body with pores and disperses drug. Urquhart developed pilocarpine ocusert as ocular therapeutic systems [14]. This was the first rate-controlled, rate specified pharmaceutical product that provides predictable, time-independent concentrations of drug in the target sites.…”

Section: Diffusionmentioning

confidence: 99%

Untitled

Sharma

Tyagi

Kumar

2019

Asian J. Nanosci. Mater.

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Ocuserts or ophthalmic inserts are "Sterile preparation in the form of solid or semisolid, whose size and shape are specially designed to be applied to the eyes". The most frequently used dosage forms (ophthalmic solutions and suspensions) are compromised in their effectiveness by several limitations, leading to poor ocular bioavailability. By utilization of the principles of the controlled release as embodied by ocular inserts offers an irritable approach to the problem of prolonging pre-corneal drug residence times. The controlled ocular drug delivery systems increased the efficiency of the drug by enhancing absorption increasing contact time of drug and by reducing drug wastage to the absorption site. Ocuserts were prepared using the solvent casting method. The article discusses about the various structure of the eye, its anatomy with an explanatory diagram. Also, various mechanisms of drug diffusion into an eye with special attention to biological/clinical performances, and potential applications and developments were discussed.

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“…The low therapeutic efficiency is caused by the complex structure of the eye, the small absorptive surface, and low transparency of the cornea, lipophilicity of corneal epithelium, metabolism, bonding of the drug to proteins in tear liquid, and protective mechanisms such as tear formation, blinking, and the flow of the active pharmaceutical ingredients (APIs) through the nasolacrimal duct [16,17]. The main challenge in the development of ophthalmic drug formulations is to achieve the required drug concentration at the site of absorption and to improve residence time, which in turn contributes to smaller application frequency [18,19].…”

Section: Encapsulation Of Rifampicin In Polyaspartamide Nanofibers Fomentioning

confidence: 99%

Electrospun Nanofibers for Entrapment of Biomolecules

Balogh‐Weiser¹,

Németh²,

Ender³

et al. 2018

Electrospinning Method Used to Create Functional Nanocomposites Films

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This chapter focuses on nanofiber fabrication by electrospinning techniques for the effective immobilization of biomolecules (such as enzymes or active pharmaceutical ingredients-APIs). In this chapter, the development of precursor materials (from commercial polymer systems to systematically designed biopolymers), entrapment protocols, and precursor-nanofiber characterization methods are represented. The entrapment ability of poly(vinyl alcohol) and systematically modified polyaspartamide nanofibers was investigated for immobilization of two different lipases (from Candida antarctica and Pseudomonas fluorescens) and for formulation of the antibacterial and antiviral agent, rifampicin. The encapsulated biomolecules in electrospun polymer fibers could be promising nanomaterials for industrial biocatalysis to produce chiral compound or in the development of smart drug delivery systems.

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The concept of ocular inserts as drug delivery systems: An overview

Cited by 34 publications

References 0 publications

Ophthalmic Drug Dosage Forms: Characterisation and Research Methods

Ophthalmic Drug Dosage Forms: Characterisation and Research Methods

Untitled

Electrospun Nanofibers for Entrapment of Biomolecules

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