Using the life cycle assessment methodology, this article analyzes the potential for developing a responsible production process for mineral fertilizers. By way of an example, the composition of the production facilities at a vertically integrated company is considered, and the main factors that negatively affect on the atmospheric air, waterbodies, and soils are identified. Based on the analysis of the best available and promising technologies, the main ways to mitigate the negative impact on the environment, human health, and natural resources are defined. It is concluded that the application of product life cycle assessment approaches makes it possible to identify priority environmental aspects at each stage and take them into consideration when developing and implementing programs to improve the resource and energy efficiency, as well as environmental performance of product production and consumption.