The concentrations of osteocalcin and degradation products of type I collagen in pregnant women with pre-eclampsia

Gorzelak, Mieczysław; Darmochwał-Kolarz, Dorota; Jabłoński, Mirosław; Roliński, Jacek; Leszczyńska‐Gorzelak, Bożena; Modrzewski, K; Oleszczuk, Jan

doi:10.1016/s0301-2115(01)00319-0

Cited by 8 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, PE occurs more frequently in women with underlying collagen vascular diseases [85] , and collagen is increased in the umbilical cord arteries in PE [86] . Although rare mutations in COL1A1 are known to cause osteogenesis imperfecta, Ehlers-Danlos syndrome, and idiopathic osteoporosis, a role for COL1A1 in PE is suggested by a study [87] , in which the concentration of degradation products of collagen type I were shown to be significantly higher (p ! 0.005) in women with PE compared to healthy pregnant women, although the sample sizes were small.…”

Section: Discussionmentioning

confidence: 99%

Candidate-Gene Association Study of Mothers with Pre-Eclampsia, and Their Infants, Analyzing 775 SNPs in 190 Genes

et al. 2006

View full text Add to dashboard Cite

Pre-eclampsia (PE) affects 5–7% of pregnancies in the US, and is a leading cause of maternal death and perinatal morbidity and mortality worldwide. To identify genes with a role in PE, we conducted a large-scale association study evaluating 775 SNPs in 190 candidate genes selected for a potential role in obstetrical complications. SNP discovery was performed by DNA sequencing, and genotyping was carried out in a high-throughput facility using the MassARRAY^TM System. Women with PE (n = 394) and their offspring (n = 324) were compared with control women (n = 602) and their offspring (n = 631) from the same hospital-based population. Haplotypes were estimated for each gene using the EM algorithm, and empirical p values were obtained for a logistic regression-based score test, adjusted for significant covariates. An interaction model between maternal and offspring genotypes was also evaluated. The most significant findings for association with PE were COL1A1 (p = 0.0011) and IL1A (p = 0.0014) for the maternal genotype, and PLAUR (p = 0.0008) for the offspring genotype. Common candidate genes for PE, including MTHFR and NOS3, were not significantly associated with PE. For the interaction model, SNPs within IGF1 (p = 0.0035) and IL4R (p = 0.0036) gave the most significant results. This study is one of the most comprehensive genetic association studies of PE to date, including an evaluation of offspring genotypes that have rarely been considered in previous studies. Although we did not identify statistically significant evidence of association for any of the candidate loci evaluated here after adjusting for multiple testing using the false discovery rate, additional compelling evidence exists, including multiple SNPs with nominally significant p values in COL1A1 and the IL1A region, and previous reports of association for IL1A, to support continued interest in these genes as candidates for PE. Identification of the genetic regulators of PE may have broader implications, since women with PE are at increased risk of death from cardiovascular diseases later in life.

show abstract

Section: Discussionmentioning

confidence: 99%

Candidate-Gene Association Study of Mothers with Pre-Eclampsia, and Their Infants, Analyzing 775 SNPs in 190 Genes

et al. 2006

View full text Add to dashboard Cite

show abstract

“…In previous studies of postmenopausal women, including those using menopausal hormone treatments (5), coronary artery calcification negatively correlated with both areal bone mineral density (aBMD) as measured by dual energy X-ray absorptiometry (DEXA) at the femur and lumbar spine (6–8) and with lumbar spinal volumetric bone mineral density (vBMD) in the trabecular region as measured by quantitative computer tomography (QCT) (9). Markers of bone turnover such as osteocalcin and the degradation products of C-terminal telopeptides of type I collagen increased during preeclamptic pregnancies (10, 11), however, these markers did not correlate with significant decreased areal bone mineral density during the pregnancy term as measured using bone ultrasound at the heel and DEXA at the femur and lumbar spine (10–12). …”

Section: Introductionmentioning

confidence: 96%

Pregnancy history, coronary artery calcification and bone mineral density in menopausal women

et al. 2017

View full text Add to dashboard Cite

Objective This study examined relationships, by pregnancy histories, between bone mineral density (BMD) and coronary artery calcification (CAC) in postmenopausal women. Methods Forty women identified from their medical record as having preeclampsia (PE) were age/parity-matched with 40 women having a normotensive pregnancy (NP). Vertebral (T04-09) BMD and CAC were assessed by Quantitative Computed Tomography in 73 (n=37 with PE and n=36 with NP) of the 80 women. Analyses included linear regression using generalized estimating equations. Results Women averaged 59 years of age and 35 years from the index pregnancy. There were no significant differences in cortical, trabecular or central BMD between groups. CAC was significantly greater in the PE group (P=0.026). In multivariable analysis, CAC was positively associated with cortical BMD (P=0.001) and negatively associated with central BMD (P=0.036). There was a borderline difference in the association between CAC and central BMD by pregnancy history (interaction, P=0.057). Conclusions Although CAC was greater in women with a history of PE, vertebral BMD did not differ between groups. However, both cortical and central BMD were associated with CAC. The central BMD association was marginally different by pregnancy history suggesting perhaps differences in underlying mechanisms of soft tissue calcification.

show abstract

“…However, urinary DPD concentration was not investigated in normal pregnancy, it was demonstrated that urinary DPD remained elevated in preeclampsia [3]. Gorzelak et al [4] found increased serum osteocalcin levels in preeclamptic patients.…”

Section: Clinical Characteristics Of the Studied Preeclamptic And Normentioning

confidence: 99%

Bone turnover in preeclamptic and normotensive pregnancy

Kumtepe

Aksoy

İngeç

2005

Intl J Gynecology & Obste

View full text Add to dashboard Cite

Pregnancy is a high bone turnover state because the maternal calcium homeostasis adopts to meet the increased calcium demands of the growing fetus. Also, previous data suggest that bone turnover is increased in preeclampsia [1,2]. The aim of this study was to investigate increase of bone turnover in both normotensive and preeclamptic pregnants.The study involved 32 patients with preeclampsia and 35 with healthy normotensive pregnants. Serum osteocalcin concentration was measured to evaluate bone formation and urinary Deoxypyridinoline (DPD) was measured to evaluate bone resorption. Only normal, singleton and systemic disease free pregnancies were included in the study. Fasting venous blood and urine samples were taken to assay serum osteocalcin and urinary DPD, respectively. Serum osteocalcin and urinary DPD was measured by luminometric assay (DPC, Diagnostics Products Corporation, Los Angeles, USA). Results were given as ng/ml for osteocalcin and nMDPD/mMCreatinine for urinary DPD. Student's t, Mann-Whitney U-tests and Spearman correlation were made by SPSS for Windows 10.0.Serum osteocalcin concentration was higher in preeclamtics than in normal pregnants (5.87F2.42 versus 2.33F1.60 ng/ml, pb0.0001). Also, urinary DPD concentration was found to be elevated in preeclampsia when compared to normal pregnancy (26.40F20.93 versus 11.21F4.81 nMDPD/mMCreatinine and pb0.0001). The characteristics of both groups are shown in Table 1. Correlations between urinary DPD and serum osteocalcin were significant in preeclampsia (r=0.57, p=0.01) and normotensive pregnancy (r=0.56, p=0.001).However, urinary DPD concentration was not investigated in normal pregnancy, it was demonstrated that urinary DPD remained elevated in preeclampsia [3]. Gorzelak et al. [4] found 0020-7292/$ -see front matter D

show abstract

The concentrations of osteocalcin and degradation products of type I collagen in pregnant women with pre-eclampsia

Cited by 8 publications

References 14 publications

Candidate-Gene Association Study of Mothers with Pre-Eclampsia, and Their Infants, Analyzing 775 SNPs in 190 Genes

Candidate-Gene Association Study of Mothers with Pre-Eclampsia, and Their Infants, Analyzing 775 SNPs in 190 Genes

Pregnancy history, coronary artery calcification and bone mineral density in menopausal women

Bone turnover in preeclamptic and normotensive pregnancy

Contact Info

Product

Resources

About