The concentration of total serum IgG and IgM in sera of healthy individuals varies at different age intervals

Jazayeri, Mir Hadi; Pourfathollah, Ali Akbar; Rasaee, Mohammad Javad; Porpak, Zahra; Jafari, Mohammad Ebrahim

doi:10.1016/j.biomag.2013.09.002

Cited by 22 publications

(17 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Total serum immunoglobulin G (IgG) levels remain unchanged between TBI and sham controls at 8 and 32 weeks post-surgery (data not shown), confirming that this increase in autoantibodies detected after TBI was specific. However, an age-related increase in serum IgG was also observed, as reported in humans (Gonzalez-Quintela et al, 2008;Jazayeri et al, 2013), and this may therefore be reflected in the elevated autoantibody response seen between 8 and 32 weeks.…”

Section: Resultssupporting

confidence: 56%

Activated CD8+ T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice

et al. 2019

View full text Add to dashboard Cite

show abstract

Section: Resultssupporting

confidence: 56%

Activated CD8+ T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The decrease in IgM level showed positive association with the frequency susceptibility of the elderly to autoimmune disease and cancer. [ 24 ] Thus, as expected, we apparently detected the increased levels of NAAbs at least in a part of healthy population that had exceeded micromolar level. Therefore, on the one hand, it can be said that one of the reasons for success of immune system largely depends on proper repertoires of NAAbs against carbohydrates that stand for their various and essential function in all tissues,[ 25 ] but on the other hand, affecting internal and external stimuli and regulation mechanisms should be considered although they are little known.…”

Section: Discussionsupporting

confidence: 82%

Evaluation of serum natural autoantibodies reaction in different hematological disorders with prospective view to their probable utilization in predictive medicine

Mosaed

Pourfathollah

Moghadam

et al. 2020

Asian J Transfus Sci

View full text Add to dashboard Cite

BACKGROUND: There are some antibodies which are present in healthy individuals without any former exposure to foreign antigens; they are known as natural autoantibodies (NAAbs). In recent years, it was shown that they probably contribute to the homeostasis of the whole body and might be present before beginning of some diseases. Thus, as new biomarkers, they are promising factors to diagnose diseases. MATERIALS AND METHODS: In this study, we drew upon samples of 924 individuals (600 controls and 324 cases) with underlying diseases of anemia, polycythemia, leukocytosis, thrombocytopenia, thrombocytosis, and pancytopenia. For detection of NAAbs against red blood cell, plasma samples were incubated with their own red cell suspension in 4°C for 18 h. Then, positive samples were evaluated for antibody screening and titration. RESULTS: Fifty-two (8.6%) controls and 58 (17.9%) cases showed positive reaction (Pv < 0.001). The prevalence of positive antibody screens among auto-positive controls was 53% and 100% among cases; moreover, strength of antibody screen reaction had a mean rank of 22.5 in controls and a mean rank of 38.5 in cases (Pv < 0.001). A significant relation was also observed between ABO blood group and prevalence of NAAbs in controls but not in cases (Pv < 0.05). CONCLUSION: The prevalence and potency of NAAbs increased along with hematological changes; moreover, the antibody reactions' pattern and titration showed significant differences between the two groups and these may be useful as biomarker for monitoring and prediction of some hematological diseases.

show abstract

“…Studies used different cut-off values for their younger (19 to 54 years) and older (40 to >100 years) age groups. Some studies employed multiple age groups with varying intervals ( 4 , 19 , 21 , 23 , 25 , 30 , 33 , 39 , 40 , 43 , 46 , 49 ).…”

Section: Resultsmentioning

confidence: 99%

Determinants of Serum Immunoglobulin Levels: A Systematic Review and Meta-Analysis

et al. 2021

View full text Add to dashboard Cite

BackgroundAn up-to-date overview of determinants of serum immunoglobulins in adults is pivotal for clinical practice and research, but currently lacking. We therefore performed a systematic review and meta-analysis to identify determinants of serum immunoglobulin levels.MethodsEmbase, Web of Science, Medline, Cochrane, and Google Scholar were searched from inception to July 11th, 2019 for articles reporting on determinants of serum immunoglobulin A, G or M (IgA, IgG or IgM) in adult humans. Random and fixed effect models were applied to obtain pooled mean differences (MDs) and 95% confidence intervals (CIs) for the association of age and sex with serum immunoglobulins.ResultsWe retrieved 117 articles reporting on determinants of serum immunoglobulins, of which 28 could be meta-analyzed. Older compared to younger individuals had higher IgA (MD: 0.38; CI: 0.18 – 0.58), but lower IgM levels (MD: -0.40; 95%: -0.66 – -0.14). Men had higher IgA (MD: 0.22; CI: 0.03 – 0.42), but lower IgM levels (MD: -0.21; CI: -0.32 – -0.10) than women. Age and sex did not influence IgG. Caucasian ethnicity was associated with lower IgA, IgG, and IgM. Smoking and corticosteroid use were associated with lower IgG. Positive associations were reported of probiotics with IgG, alcohol with IgA, hypertension with IgA and IgG, and acute psychological stress with IgA, IgG, and IgM.ConclusionsOlder age and male sex are associated with higher IgA, but lower IgM, and urge investigation of age- and sex-specific reference ranges of immunoglobulins. Other identified determinants were ethnicity, diet, lifestyle and cardio-metabolic factors.

show abstract

The concentration of total serum IgG and IgM in sera of healthy individuals varies at different age intervals

Cited by 22 publications

References 23 publications

Activated CD8+ T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice

Activated CD8+ T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice

Evaluation of serum natural autoantibodies reaction in different hematological disorders with prospective view to their probable utilization in predictive medicine

Determinants of Serum Immunoglobulin Levels: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About