The concentration of resistin in perivascular adipose tissue after CABG and postoperative atrial fibrillation

Abstract

BackgroundPostoperative atrial fibrillation occurs in up to 30% of patients after coronary artery bypass graft (CABG) and its cause is unknown. The aim of the study was to evaluate whether concentration of resistin in surrounding coronary artery perivascular adipose tissue (PVAT) is related to postoperative atrial fibrillation occurrence.MethodsA total number of 46 patients (35 male, 11 female; median age 66.5) were qualified for elective CABG. Medical history, laboratory test results and echocardiographic parameters were noted. Patients were monitored up to 3 days after CABG and then were divided into groups with and without postoperative atrial fibrillation occurrence. Fragments of PVAT were collected intra-operatively: near the left anterior descending artery and main left coronary artery. The concentration of resistin was determined by Human Resistin Quantikine ELISA Kit and expressed as ng/g. A multivariate stepwise logistic regression analysis was performed to find variables related to postoperative atrial fibrillation occurrence.ResultsPostoperative atrial fibrillation occurred in 14 (30.4%) patients. The patients with and without postoperative atrial fibrillation were similar in age, gender, epicardial adipose tissue thickness and laboratory parameters. The concentration of resistin in PVAT near the left main coronary artery was significantly higher in patients with postoperative atrial fibrillation than in those without the complication (P = 0.03). In the multivariate stepwise logistic regression analysis the concentration of resistin above cut-off point 54 ng/g in PVAT near left main coronary artery was independently related to postoperative atrial fibrillation occurrence (OR: 7.7; 95% CI:1.4–42.2 p = 0.02).ConclusionsThe higher concentrations of resistin in PVAT near the left main coronary artery which is located close to the left atrium are associated with postoperative atrial fibrillation.

Blood Plasma Resistin and Atrial Fibrillation in Patients With Cardiovascular Disease

“…The above suspicion and theory could also be combined with the fact that obesity is considered a risk factor for the occurrence of AF. This is supported by another study showing that adipose tissue is associated with the development of postoperative AF in cardiac surgery patients [ 30 ].…”

“…The above suspicion and theory could also be combined with the fact that obesity is considered a risk factor for the occurrence of AF. This is supported by another study showing that adipose tissue is associated with the development of postoperative AF in cardiac surgery patients [30]. The mechanism of fibrous tissue growth in the atrial wall is most likely due to chronic inflammation that develops due to chronic pressure on the walls that results from chronic volume overload which is observed in patients mainly with PAF [24].…”

“…Many researchers have tried to associate the increased concentration of resistin in patients with CVD and left ventricular dysfunction and heart failure [ 16 , 18 ]. On the other hand, mitochondria play a central role in the function of cardiac myocyte and many of the pathophysiological processes involved in AF are related with the mitochondria function, including reactive oxygen species (ROS) formation and the changes in oxygen consumption in the myocardial cells of the heart [ 30 - 34 ]. Oxidative stress and inflammation are closely linked because inflammation can lead to ROS production and ROS could also promote the synthesis of pro-inflammatory cytokines such as interleukin (IL)-6, IL-8, IL-10, IL-12 and tumor necrosis factor alpha (TNF-α) [ 33 ].…”

Is Epicardial Adipose Tissue Associated with Atrial Fibrillation Following Cardiac Surgery? A Systematic Review and Meta-Analysis

“…EAT is an ectopic adipose tissue, including fat depots (such as pericardial fat, perivascular fat, and myocardial steatosis), between the myocardium and visceral pericardium. Based on the location, it is easy to understand the physiological functions of the EAT, which include supplying the cardiomyocytes with energy from lipids storage, protecting autonomic ganglia and nerve tissue, and regulating coronary vessels [Rachwalik 2019]. Therefore, EAT may play a central role in cardiovascular disease pathogenesis [Zhou 2020].…”

“…Since then, more than 10 studies have been performed on this topic. However, they have been done in different populations and included different procedures (coronary artery bypass grafting or valve replacement) with different EAT measurements (computed tomography [CT] and echocardiography) and diverse intervals of follow up [Rachwalik 2019;Drossos 2014;Wang 2019;Opolski 2015;Kogo 2019;Liu 2020;Gunturk 2020;Ozbek 2018]. This study is the first attempt to prove the association between AFACS and EAT in patients with and without AF following cardiac surgery, via systematic review, and meta-analysis.…”