The CONCENTRATION OF PROSTAGLANDIN F2α IN MATERNAL PLASMA, FOETAL PLASMA AND AMNIOTIC FLUID DURING PREGNANCY IN WOMEN

Johnson, Donna A.; Manning, Patrice A.; Hennam, J.F.; Newton, Richard; Collins, William P.

doi:10.1530/acta.0.0790589

Cited by 6 publications

(2 citation statements)

References 3 publications

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“…Of the included amniotic fluid studies, 15 measured prostaglandins at more than one time point throughout pregnancy. PGF 2α , PGF 1α , and PGF were generally found to increase around term or prior to labour [ 17 , 22 , 27 , 28 , 30 , 37 , 52 , 82 , 85 ], though two studies found no pattern throughout pregnancy [ 26 , 33 ]. Among studies that measured PGE or PGE 2 , most (4/6) reported increased levels around 35–36 weeks [ 30 , 37 , 52 , 85 ].…”

Section: Resultsmentioning

confidence: 99%

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Prostaglandins in biofluids in pregnancy and labour: A systematic review

2021

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Prostaglandins are thought to be important mediators in the initiation of human labour, however the evidence supporting this is not entirely clear. Determining how, and which, prostaglandins change during pregnancy and labour may provide insight into mechanisms governing labour initiation and the potential to predict timing of labour onset. The current study systematically searched the existing scientific literature to determine how biofluid levels of prostaglandins change throughout pregnancy before and during labour, and whether prostaglandins and/or their metabolites may be useful for prediction of labour. The databases EMBASE and MEDLINE were searched for English-language articles on prostaglandins measured in plasma, serum, amniotic fluid, or urine during pregnancy and/or spontaneous labour. Studies were assessed for quality and risk of bias and a qualitative summary of included studies was generated. Our review identified 83 studies published between 1968–2021 that met the inclusion criteria. As measured in amniotic fluid, levels of PGE2, along with PGF2α and its metabolite 13,14-dihydro-15-keto-PGF2α were reported higher in labour compared to non-labour. In blood, only 13,14-dihydro-15-keto-PGF2α was reported higher in labour. Additionally, PGF2α, PGF1α, and PGE2 were reported to increase in amniotic fluid as pregnancy progressed, though this pattern was not consistent in plasma. Overall, the evidence supporting changes in prostaglandin levels in these biofluids remains unclear. An important limitation is the lack of data on the complexity of the prostaglandin pathway outside of the PGE and PGF families. Future studies using new methodologies capable of co-assessing multiple prostaglandins and metabolites, in large, well-defined populations, will help provide more insight as to the identification of exactly which prostaglandins and/or metabolites consistently change with labour. Revisiting and revising our understanding of the prostaglandins may provide better targets for clinical monitoring of pregnancies. This study was supported by the Canadian Institutes of Health Research.

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Section: Resultsmentioning

confidence: 99%

“…In total, 18 studies obtained measurements of plasma throughout pregnancy. Among those that measured PGF 2α , some found increasing levels at or near term [ 37 , 50 , 60 ] however results were conflicting [ 21 , 28 , 33 ]. In 5/6 studies PGFM was not found to change with increasing gestational age [ 39 , 41 , 43 , 44 , 58 ].…”

Section: Resultsmentioning

confidence: 99%