The Concentration of I131 in the Bronchial Tree after Oral Administration of Tagged CaI2 and KI

Lopez-Belio, M; Henderson, W. J.; Mansueto, Mario D.; Holinger, Paul H.

doi:10.1378/chest.39.2.158

Cited by 13 publications

(4 citation statements)

References 3 publications

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“…Intriguingly, iodide has been used to thin mucus secretions in the respiratory tract as an expectorant drug for asthma or other pulmonary diseases [20]. It was also found that orally administered radio-iodide reaches bronchial lumen [21]. This transport of iodide across the bronchial mucosa may be conducted by NIS.…”

Section: Discussionmentioning

confidence: 99%

Effect of thyroid statuses on sodium/iodide symporter (NIS) gene expression in the extrathyroidal tissues in mice

et al. 2010

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BackgroundIodide that is essential for thyroid hormone synthesis is actively transported into the thyroid follicular cells via sodium/iodide symporter (NIS) protein in vertebrates. It is well known that NIS expression in thyroid is regulated by the thyroid statuses mainly through thyroid stimulating hormone (TSH). Although NIS mRNA expressions in extrathyroidal tissues have been qualitatively reported, their regulation by thyroid statuses has not been well clarified.MethodsMale ICR mice aged four weeks were assigned into three groups (control, hypothyroid, and hyperthyroid). Hypothyroid group of mice were treated with 0.02% methimazole in drinking water and hyperthyroid group of mice received intraperitoneal injection (4 μg L-T4 twice a week) for four weeks. NIS mRNA expression levels in the tissues were evaluated using Northern blot hybridization and quantitative real-time RTPCR (qPCR). Additionally, end-point RTPCR for the thyroid follicular cell-characteristic genes (TSH receptor, TSHR; thyroid transcription factor-1, TTF1; and paired box gene 8, Pax8) was carried out.ResultsBy Northern blot analysis, NIS mRNA was detected in thyroid and stomach. In addition to these organs, qPCR revealed the expression also in the submandibular gland, colon, testis, and lung. Expression of NIS mRNA in thyroid was significantly increased in hypothyroid and decreased in hyperthyroid group. Trends of NIS mRNA expression in extrathyroidal tissues were not in line with that in the thyroid gland in different thyroid statuses. Only in lung, NIS mRNA was regulated by thyroid statuses but in opposite way compared to the manner in the thyroid gland. There were no extrathyroidal tissues that expressed all three characteristic genes of thyroid follicular cells.ConclusionsNIS mRNA expression in the thyroid gland was up-regulated in hypothyroid mice and was down-regulated in hyperthyroid mice, suggesting that NIS mRNA in the thyroid gland is regulated by thyroid statuses. In contrast, NIS mRNA expression in extrathyroidal tissues was not altered by thyroid statuses although it was widely expressed. Lack of responsiveness of NIS mRNA expressions in extrathyroidal tissues reemphasizes additional functions of NIS protein in extrathyroidal tissues other than iodide trapping.

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Section: Discussionmentioning

confidence: 99%

Effect of thyroid statuses on sodium/iodide symporter (NIS) gene expression in the extrathyroidal tissues in mice

et al. 2010

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“…SVDs are invariably associated with PAPVR ( 1 ). The classic surgical approach is placement of a patch-baffle that closes the defect and redirects anomalous pulmonary veins into the left atrium, with a risk for venous obstruction ( 2 ). Superior insertion of pulmonary veins extends the length of the baffle with increased risk for obstruction.…”

Section: Casementioning

confidence: 99%

4-Dimensional Flow by Cardiac Magnetic Resonance Informs Surgical Planning in Partial Anomalous Pulmonary Venous Return

et al. 2020

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Four-dimensional flow cardiac magnetic resonance enhances the visualization of blood flow in a 3-dimensional volume throughout the cardiac cycle, thus dramatically improving visualization of pulmonary venous anatomy by cardiac magnetic resonance. We demonstrate the impact of 4-dimensional flow on diagnosis and surgical planning for partial anomalous pulmonary venous return. ( Level of Difficulty: Beginner. )

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“…In fact, this can be easily observed if some PVPI solution is added drop wise directly into excess CaCl 2 solution, where the characteristic orange color of PVPI slowly turns colorless. CaI 2 is a standard medicinal compound which is especially effective for bronchopulmonary diseases having also a partial antiseptic effect (Lopez-Belio, Henderson, Mansueto, & Holinger, 1961). Therefore, formation of CaI 2 is not considered as a drawback but as an added functionality opening up new application possibilities for these beads such as orally administered antiseptic and expectorant (cough, asthma, bronchitis and cystic fibrosis releaving agent).…”

Section: Measurement Of Pvpi Release From Naalg Films and Caalg Beadsmentioning

confidence: 99%

Controlled antiseptic release by alginate polymer films and beads

Liakos

Rizzello

Bayer

et al. 2013

Carbohydrate Polymers

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The Concentration of I131 in the Bronchial Tree after Oral Administration of Tagged CaI2 and KI

Cited by 13 publications

References 3 publications

Effect of thyroid statuses on sodium/iodide symporter (NIS) gene expression in the extrathyroidal tissues in mice

Effect of thyroid statuses on sodium/iodide symporter (NIS) gene expression in the extrathyroidal tissues in mice

4-Dimensional Flow by Cardiac Magnetic Resonance Informs Surgical Planning in Partial Anomalous Pulmonary Venous Return

Controlled antiseptic release by alginate polymer films and beads

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