The concentration of D-dimers in portal blood positively correlates with overall survival in patients with non-resectable pancreatic cancer

Durczyński, Adam; Skulimowski, Aleksander; Hogendorf, Piotr; Szymański, Dariusz; Kumor, Anna; Marski, Konrad; Juliebø, Siri Øvereng; Poznańska, Grażyna; Strzelczyk, Janusz

doi:10.1186/s12957-017-1291-4

Cited by 13 publications

(11 citation statements)

References 10 publications

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“…Other recent studies have shown that plasma D-dimer values may predict overall survival and progression free survival in patients with pancreatic cancer (40,41). In accordance with the above studies, the present study confirmed a positive association between D-dimer level and tumorigenesis.…”

Section: Cases With Low and High D-dimer Level N (%) ---------------supporting

confidence: 92%

D‑dimer as a potential clinical marker for predicting metastasis and progression in cancer

et al. 2018

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D-dimer is a widely used biomarker for indicating the activation of coagulation and fibrinolysis, and is reported to serve important roles in cancer progression. The aim of the current retrospective study was to investigate the association of D-dimer plasma level with the development of various cancers. Patients with breast (n=86), gastric (n=317), pancreatic (n=37), colon (n=153) and rectal (n=137) cancers and 92 healthy volunteers were assessed in the present study. Plasma levels of D-dimer in the patients and healthy controls were measured by immunoturbidimetric assays. The association of D-dimer levels with the clinicopathological features of patients were also determined. The plasma levels of D-dimer were significantly higher in patients with breast cancer (P=0.0022), gastric cancer (P<0.0001), pancreatic cancer (P=0.0003), colon cancer (P=0.0001) and rectal cancer (P=0.0028), compared with the healthy controls. It was also determined that the plasma D-dimer levels were positively associated with clinical cancer stage (P<0.05) and metastasis (P<0.05). These findings suggested that the plasma D-dimer level may be used as marker for predicting cancer metastasis and progression.

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Section: Cases With Low and High D-dimer Level N (%) ---------------supporting

confidence: 92%

D‑dimer as a potential clinical marker for predicting metastasis and progression in cancer

et al. 2018

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“…The abnormalities of coagulation and fibrinolysis are frequently observed in cancer patients. A recent meta-analysis suggested that plasma D-dimer and fibrinogen levels were correlated with tumor stage and prognosis in digestive cancer patients [35–37]. High pretreatment plasma D-dimer was reported to predict poor survival of colorectal cancer [38, 39].…”

Section: Discussionmentioning

confidence: 99%

The impact of pharmacological thromboprophylaxis and disease-stage on postoperative bleeding following colorectal cancer surgery

et al. 2019

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Background Pharmacological thromboprophylaxis after colorectal cancer (CRC) surgery is internationally recommended for venous thromboembolism (VTE) prevention. The aim of this retrospective study was to evaluate the risk factors of postoperative bleeding after elective surgery for patients with primary CRC receiving pharmacological thromboprophylaxis of fondaparinux or enoxaparin. Methods We experienced consecutive 266 patients who underwent elective surgery for CRC during the study period. Finally, the medical records of 218 patients with CRC administrated fondaparinux or enoxaparin following surgery were retrospectively reviewed to evaluate symptomatic VTE until 28 days and postoperative bleeding comparing perioperative D-dimer levels. Results The significant differences in TNM classification staging and type of thromboprophylaxis were observed between postoperative bleeding-negative and bleeding-positive group. There was no statistical significance among other backgrounds of patients between the two groups. One case (0.46%) of symptomatic VTE and total 11 cases (5%) of postoperative bleeding were observed. In the univariate analysis, fondaparinux thromboprophylaxis and early disease-stage CRC (stages 0 and I) were associated with risk for postoperative bleeding. Multivariate analysis revealed that fondaparinux thromboprophylaxis was identified as an independent risk factor of postoperative bleeding. Moreover, preoperative levels of D-dimer in patients with stage IV CRC were significantly higher than those with the other stages. The significant elevation in preoperative D-dimer was also observed in patients with stage II CRC compared to those with stage I CRC. Perioperative levels of D-dimer in patients with advanced disease-stage CRC (stages II, III, and IV) were significantly higher than those in patients with early disease-stage CRC. Conclusions Fondaparinux administration and early disease-stage CRC appeared to be risk factors for postoperative bleeding in patients with pharmacological thromboprophylaxis undergoing surgical treatment for CRC. Patients’ hypercoagulative condition depending on disease progression of CRC might be related to the occurrence of postoperative bleeding following CRC surgery.

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“…Given that the occurrence of deep venous thrombosis (DVT) is mostly concealed, the mortality is relatively high. 1,2 Consequently, if early diagnosis and thrombolytic therapy can be promptly achieved, the fatality rate of DVT will be greatly reduced. However, the definite diagnosis of DVT is generally based on imaging examinations, which are expensive, time-consuming, and partially invasive.…”

Section: Introductionmentioning

confidence: 99%

The Diagnostic Efficacy of Age-Adjusted D-Dimer Cutoff Value and Pretest Probability Scores for Deep Venous Thrombosis

Zhang

Liang

et al. 2019

Clin Appl Thromb Hemost

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This study seeks to evaluate the diagnostic value of D-Dimer Plus and Innovance D-Dimer as well as the age-adjusted cutoff value for D-dimer detection in combination with 4 pretest probability (PTP) scores for deep venous thrombosis (DVT). A total of 688 patients referred for lower extremity vascular compression venous ultrasonography for suspected DVT from January 2016 to May 2018 in the First Affiliated Hospital of Sun Yat-sen University underwent D-dimer tests combining with 4 PTP scores. The diagnostic efficacy of the Wells score was the highest of the 4 PTP scores. The diagnostic efficacy of Innovance D-Dimer for DVT was greater than that of D-Dimer Plus, with better sensitivity and negative predictive value, which were both greater than 98%. If the cutoff values were adjusted by age, the Innovation D-Dimer could further improve both the specificity and the positive predictive value, providing better diagnostic performance. When the 2 D-dimer detections were used in combination with 4 PTP scores for DVT diagnosis, separately, both the positive predictive value and the negative predictive value significantly improved for D-Dimer Plus, and the positive predictive values significantly improved for Innovance D-Dimer. However, the sensitivity, specificity, and negative predictive values did not obviously change. For our patients, Wells score had the best diagnostic efficacy for our patients with suspected DVT among the 4 PTP scores. Innovance D-Dimer in combination with age-adjusted cutoff values exhibited increased sensitivity and negative predictive value for DVT diagnosis and was equivalent to the diagnostic efficacy of the Innovance D-Dimer in combination with PTP scores.

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The concentration of D-dimers in portal blood positively correlates with overall survival in patients with non-resectable pancreatic cancer

Cited by 13 publications

References 10 publications

D‑dimer as a potential clinical marker for predicting metastasis and progression in cancer

D‑dimer as a potential clinical marker for predicting metastasis and progression in cancer

The impact of pharmacological thromboprophylaxis and disease-stage on postoperative bleeding following colorectal cancer surgery

The Diagnostic Efficacy of Age-Adjusted D-Dimer Cutoff Value and Pretest Probability Scores for Deep Venous Thrombosis

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