The Concentration of Cd, Cu, Fe. Ni, Pb, and Zn in Bituminous Coals from Mines with Differing Incidences of Coal Workers' Pneumoconiosis

Sorenson, John R. J.; Kober, Thomas E.; Petering, Harold G.

doi:10.1080/0002889748507011

Cited by 9 publications

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“…In addition to the carbon, which is the main component, coal also contains oxygen, nitrogen, hydrogen, and trace elements, and several inorganic minerals. The trace elements may include copper, nickel, cadmium, boron, antimony, iron, lead, and zinc (8). Some of these trace elements can be cytotoxic and carcinogenic in experimental models (9).…”

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confidence: 99%

Respirable Coal Dust Particles Modify Cytochrome P4501A1 (CYP1A1) Expression in Rat Alveolar Cells

Ghanem

Porter²,

Battelli³

et al. 2004

Am J Respir Cell Mol Biol

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Cytochrome P4501A1 (CYP1A1) metabolizes polycyclic aromatic hydrocarbons in cigarette smoke to DNA-binding reactive intermediates associated with carcinogenesis. Epidemiologic studies indicate that the majority of coal miners are smokers but have a lower risk of lung cancer than other smokers. We hypothesized that coal dust (CD) exposure modifies pulmonary carcinogenesis by altering CYP1A1 induction. Therefore, male Sprague Dawley rats were intratracheally instilled with 2.5, 10, 20, or 40 mg CD/rat or vehicle (saline); and 11 d later, pulmonary CYP1A1 was induced by intraperitoneal injection of beta-naphthoflavone (BNF; 50 mg/kg). Fourteen days after CD exposure, CYP1A1 protein and activity were measured by Western blot and 7-ethoxyresorufin-O-deethylase activity, respectively. CYP1A1 and the alveolar type II markers, cytokeratins 8/18, were localized and quantified in lung sections by dual immunofluorescence with morphometry. The area of CYP1A1 expression in alveolar septa and alveolar type II cells in response to BNF was reduced by exposure to 20 or 40 mg CD compared with BNF alone. CD exposure significantly inhibited BNF-induced 7-ethoxyresorufin-O-deethylase activity in a dose-responsive manner. By Western blot, induction of CYP1A1 protein by BNF was significantly reduced by 40 mg CD compared with BNF alone. These findings indicate that CD decreases BNF-induced CYP1A1 protein expression and activity in the lung.

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confidence: 99%

Respirable Coal Dust Particles Modify Cytochrome P4501A1 (CYP1A1) Expression in Rat Alveolar Cells

Ghanem

Porter²,

Battelli³

et al. 2004

Am J Respir Cell Mol Biol

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“…On the basis of these contradictory results of in vitro and in vivo studies, International Agency for Research on Cancer (IARC) has classified coal dust in Group 3 [IARC, 1997]. Coal dust contains trace elements (copper, nickel, cadmium, antimony, iron, lead, zinc) and quartz which could be responsible for its genotoxic effects [Sorenson et al, 1974;Castranova, 2000]. IARC classified quartz into Group 1 (human carcinogen) [IARC, 1997].…”

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confidence: 99%

Cytogenetic monitoring of coal workers and patients with coal workers' pneumoconiosis in Turkey

Ülker

Üstündağ

Duydu

et al. 2008

Environ and Mol Mutagen

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Occupational exposure to coal dust causes coal workers' pneumoconiosis (CWP), which is a chronic inflammatory and fibrotic lung disease. Recently, chronic inflammation has been accepted as a crucial factor in the pathogenesis of neoplasia. The chronic inflammation provides dynamic setting for oxidative stress and formation of free radicals. Interaction of reactive oxygen species (ROS) with DNA augments the likelihood of DNA structural and transcriptional errors. The purpose of this study was to investigate the genotoxic risk in pneumoconiotic patients and in those with occupational exposure to coal dust. Therefore, sister chromatid exchange (SCE) and micronucleus (MN) tests were performed in Turkish CWP patients, coal workers, and an unexposed control group. Both SCE and MN frequencies in CWP patients were found significantly higher than in coal worker and unexposed groups. There were no differences between SCE and MN frequencies of coal worker and unexposed groups. On the other hand, no correlation between SCE frequency, duration of exposure, and age was observed in all three groups. There was also no effect of smoking on the frequencies of SCE and MN in the groups. Based on these results, it might be suggested that development of CWP leads to a significant induction of cytogenetic damage in peripheral lymphocytes of CWP patients. This is the first report on CWP patients with elevated cytogenetic endpoints. Further, a larger follow-up study is warranted.

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Coal: Response of cultured mammalian cells corresponds to the prevalence of coal workers pneumoconiosis

Christian

Nelson

1978

Environmental Research

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The Concentration of Cd, Cu, Fe. Ni, Pb, and Zn in Bituminous Coals from Mines with Differing Incidences of Coal Workers' Pneumoconiosis

Cited by 9 publications

References 0 publications

Respirable Coal Dust Particles Modify Cytochrome P4501A1 (CYP1A1) Expression in Rat Alveolar Cells

Respirable Coal Dust Particles Modify Cytochrome P4501A1 (CYP1A1) Expression in Rat Alveolar Cells

Cytogenetic monitoring of coal workers and patients with coal workers' pneumoconiosis in Turkey

Coal: Response of cultured mammalian cells corresponds to the prevalence of coal workers pneumoconiosis

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