The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults

Taylor, Warren D.; Züchner, Stephan; Payne, Martha E.; Messer, Denise F.; Doty, Tracy Jill; MacFall, James R.; Beyer, John L.; Krishnan, K. Ranga Rama

doi:10.1016/j.pscychresns.2007.01.005

Cited by 59 publications

(51 citation statements)

References 14 publications

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“…Interestingly, this association has not been found in studies that included patients with any psychosis, 79,80,83 indicating that the association may be specific to schizophrenia. In healthy individuals, smaller hippocampal, 9,78,81,82 amygdalar, 9 total and grey matter temporal lobe 82 volumes as well as reduced thickness of the right superior temporal sulcus 77 have been reported in Val/Val carriers. In contrast, other studies have failed to find a significant association between the COMT Val 158 Met polymorphism and temporal lobe volumes in healthy individuals or in unaffected relatives of patients with psychosis.…”

Section: Temporal Regionsmentioning

confidence: 97%

COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation

Ira

Zanoni

Ruggeri

et al. 2013

J Psychiatry Neurosci

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Section: Temporal Regionsmentioning

confidence: 97%

COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation

Ira

Zanoni

Ruggeri

et al. 2013

J Psychiatry Neurosci

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“…Genetic factors are also important in determining cortical architecture (Thompson et al, 2001;Lenroot et al, 2007). Common polymorphisms such as the catechol-O-methyltransferase Val158Met polymorphism, a single nucleotide polymorphism in the regulator of G-protein signaling 4 gene, and a promoter region polymorphism of the serotonin transporter gene (5-HTTLPR) have all been found to have some influence on cortical volume, thickness or complexity (Brown and Hariri, 2006;Meyer-Lindenberg et al, 2006;Zinkstok et al, 2006;Buckholtz et al, 2007;Taylor et al, 2007). Of particular interest are genes that both contribute to both cortical growth and complexity and appear to be under positive selection in primate evolution, particularly in lineages leading to modern humans (Gilbert et al, 2005).…”

Section: Environmental and Genetic Effects On Growth Trajectoriesmentioning

confidence: 99%

Neurodevelopmental Trajectories of the Human Cerebral Cortex

Shaw¹,

Kabani²,

Lerch³

et al. 2008

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Understanding the organization of the cerebral cortex remains a central focus of neuroscience. Cortical maps have relied almost exclusively on the examination of postmortem tissue to construct structural, architectonic maps. These maps have invariably distinguished between areas with fewer discernable layers, which have a less complex overall pattern of lamination and lack an internal granular layer, and those with more complex laminar architecture. The former includes several agranular limbic areas, and the latter includes the homotypical and granular areas of association and sensory cortex. Here, we relate these traditional maps to developmental data from noninvasive neuroimaging. Changes in cortical thickness were determined in vivo from 764 neuroanatomic magnetic resonance images acquired longitudinally from 375 typically developing children and young adults. We find differing levels of complexity of cortical growth across the cerebrum, which align closely with established architectonic maps. Cortical regions with simple laminar architecture, including most limbic areas, predominantly show simpler growth trajectories. These areas have clearly identified homologues in all mammalian brains and thus likely evolved in early mammals. In contrast, polysensory and high-order association areas of cortex, the most complex areas in terms of their laminar architecture, also have the most complex developmental trajectories. Some of these areas are unique to, or dramatically expanded in primates, lending an evolutionary significance to the findings. Furthermore, by mapping a key characteristic of these development trajectories (the age of attaining peak cortical thickness) we document the dynamic, heterochronous maturation of the cerebral cortex through time lapse sequences ("movies").

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“…24 Importantly, COMT is highly expressed in the hippocampus. 25,26 Recent studies of healthy individuals suggest that Val carriers have smaller hippocampal volumes than Met carriers, 27,28 possibly owing to alterations in the neural correlates of memory function.…”

Section: J Psychiatry Neurosci 2017;42(2)mentioning

confidence: 99%