We study the coe cients of the Schur expansion of iterated plethysms,For certain choices of 𝜆 1 , …, 𝜆 𝑘 , these coe cients express partial symmetries. We formalize this symmetry by means of an involution on partitions, and show that if 𝑓 has this symmetry, then 𝑠 𝜆 • 𝑓 too for 𝜆 ∈ Par(2).We give explicit formulas for the plethysms 𝑠 2 • 𝑠 𝑏 • 𝑠 𝑎 and 𝑠 𝑐 • 𝑠 2 • 𝑠 𝑎 , 𝑎, 𝑏, 𝑐 ∈ N ≥2 and show that they have this partial symmetry. Finally, we make some remarks and conjectures regarding unimodality and asymptotic normality of the coe cients involved.