The compression characteristics of microcrystalline cellulose powders

Sixsmith, David

doi:10.1111/j.2042-7158.1982.tb04726.x

Cited by 9 publications

(1 citation statement)

References 6 publications

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“…Examples of materials consolidating by plastic deformation are sodium chloride, starch and microcrystalline cellulose (8,11,12). Fragmenting materials are, for example crystalline lactose, sucrose and Emcompress@ (8,(13)(14)(15)(16).…”

Section: Fragmentation Of Particles 5 Formation Of Interparticulate mentioning

confidence: 99%

Bonding Surface area and Bonding Mechanism-Two Important Factors fir the Understanding of Powder Comparability

Nyström

Alderborn

Duberg

et al. 1993

Drug Development and Industrial Pharmacy

201

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Two factors could be regarded as primary factors for the compactability of powders: the dominating bond mechanism and the surface area over which these bonds are active. Owing to considerable experimental difficulties, these factors have not been evaluated in any detail for pharmaceutical materials. Instead, more indirect, secondary factors are normally studied and used for correlations with tablet strength. Such secondary factors particle size, shape and surface texture. Also the importance of volume reduction mechanisms, i.e. elastic deformation, plastic deformation and particle fragmentation have been studied in detail.For the investigation of dominating bond mechanisms and estimation of the magnitude of the surface area of the solids involved in interparticulate attraction in compacts several pharmaceutical excipients representing both plastically deforming materials (sodium chloride, Avicel@ PH 101, Sta-Rx 1500@, and sodium 2143

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