“…During red wine fermentation and aging processes, biochemical reaction precursor compounds such as (+)-catechin and p -coumaric acid are incorporated into different polymers with molecular weights ranging from 5 kDa to more than 50 kDa. , These high-molecular-mass polymeric polyphenols (HPPCs) , consist of covalently bonded segments of polyphenols, including anthocyanins, flavan-3-ols, and pyranoanthocyanins and are responsible for red wine’s color, astringency, and antioxidant activity. , The complex interactions between HPPCs and aroma compounds depend on various factors, including the type and structure of the aroma compounds and polymers and the composition of the wine matrix. These factors determine the physicochemical properties such as polarity, solubility, volatility, and molecular size. − Moreover, environmental conditions such as temperature, relative humidity, pH, and oxygen availability also play a role . Thus, changes in the molecular interactions between aroma compounds and HPPCs can manifest as observable macroscopic changes, ultimately modulating the red wine’s aroma profile.…”