The complications of radium therapy in gynecology

Ward, George Gray

doi:10.1016/s0002-9378(33)90415-9

Cited by 7 publications

(4 citation statements)

References 3 publications

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“…Of this number 14 died after the first course of therapy, and in 3 cases death followed 876 re-radiation several years after initial treatment. As previously noted, 12 fatalities were due to inflammatory sequelae, and of the 5 remaining patients, one died of embolism, and the other 4 became weaker and died without adequate cause being found either clinically or at autopsy. The pathology of this collapse which is liable to follow irradiation is not clear, but Jeanneney and AuthiP suggest that it is related to the intoxication which follows the disintegration and absorption of the tissue proteins of the neoplasm.…”

supporting

confidence: 63%

The Complications of Radium Therapy in Cancer of the Uterine Cervix*

Maliphant

1939

BJOG

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ALTHOUGH the treatment of cancer of the uterine cervix is now almost entirely radiological, the best method of irradiation is still unsettled. The merit of any technique is customarily assessed on its five-year salvage, but this is unsatisfactory in so far as judgment is based on an incomplete picture of the results of therapy. The wide employment of radium in advanced cancers demands an evaluation of its effects from the standpoint of palliation as well as of cure, and this is not possible without some knowledge of the dangers associated with its use: I t is the purpose of this investigation to examine the complications of therapy in 650 consecutive cases of cervical cancer irradiated in the Gynaecological Department of the Cardiff Royal Infirmary. In the earlier years the supply of radium was contained in IZ needles with a screenage of 0.5 mm. of platinum, which were embedded in and about the tumour as previously described by Strachan.' From 80 to 120 mg. of radium element were so applied, usually for a period of 24 hours. In 1930 interstitial irradiation was abandoned in favour of a fractional intracavitary method based on the technique introduced by Heyman of Stockholm, and this is the method still employed. A tube of 50 mg. of radium is placed in the uterine cavity, when this is easily effected, and one or more silver boxes containing a total of 50 to 80 mg. are apposed to the vaginal aspect of the growth. The applicators are enveloped in thin rubber and screenage is the equivalent of 1.5 mm. of platinum.Two exposures, each usually of 30 hours, are given, separated by an interval of one week. In both methods the vagina is firmly packed with gauze, and an indwelling catheter is used during irradiation. The patient subsequently receives a daily vaginal

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confidence: 63%

The Complications of Radium Therapy in Cancer of the Uterine Cervix*

Maliphant

1939

BJOG

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“…I n some cases in which a rectal fistula is present and the disease has been cured repair may be attempted, and we have had success with this on one occasion, while GRAY U'ARD (8) has recorded two similar cases.…”

Section: Strachanmentioning

confidence: 95%

“…8 5 per cent. The causes of death were acute pyelonephritis (2), septicaemia (2) and peritonitis (8). These were all advanced cases and it would appear that this complication is predisposed to by the introduction of the uterine tube as in the cases in which the cervical canal could not be found the incidence of fatal infection was only one third of that when the intra-uterine tube was inserted.…”

Section: Strachanmentioning

confidence: 99%

Some Complicating Factors in the Radium Treatment of Carcinoma of the Cervix Uteri

Strachan

1947

Acta Radiologica

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“…In MALIPHANT'S analysis 12 deaths occurred and this represented 1.85 per cent. The causes of death were acute pyelo nephritis (2), septicaemia (2) and peritonitis (8). These were all advanced cases and it would appear that this complication is predisposed to by the introduction of the uterine tube as in the cases in which the cervical canal could not be found the incidence of fatal infection was only one third of that when the intra-uterine tube was inserted.…”

Section: Post-operative Complications Of Radium Therapymentioning

confidence: 99%

Some Complicating Factors in the Radium Treatment of Carcinoma of the Cervix Uteri

Strachan

1947

Acta Radiologica

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The treatment of carcinoma of the cervix by radium can no longer be regarded as new therapy. On the contrary it has been practised for a sufficient number of years to permit of the publication from many centres of the results of treatment of large numbers of cases, and their follow-up for many years afterwards.In the early days of this therapy the method of treatment, the dosage and the duration of the application were largely experimental and had to be determined to a certain extent by methods of trial and error. In this connection we owe much to the pioneer work of KELLY and BURKAM in America, LACASSAGNK and WJCKHAM in France and FORS-SELL and HEYMAN in Sweden; and it is HEYMAN whose work we are so glad to acknowledge and to appreciate in this publication.In general it may be said that the earlier methods of therapy consisted in the insertion of a varying number of radium-charged needles of dif fering strength into the substance of the tumour and these methods were reviewed by the writer in 1929 (1). A certain degree of success Was ob tained by multiple radium needle puncture, but the undesirable feature of this method was traumatisation of the growth which was unavoidable. The essential feature of the FORSSELL-HEYMAN technique, however, lay in the avoidance of such traumatisation of the growth. Into the in terior of the uterus, in cases in which the cervical canal can be found,

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The complications of radium therapy in gynecology

Cited by 7 publications

References 3 publications

The Complications of Radium Therapy in Cancer of the Uterine Cervix*

The Complications of Radium Therapy in Cancer of the Uterine Cervix*

Some Complicating Factors in the Radium Treatment of Carcinoma of the Cervix Uteri

Some Complicating Factors in the Radium Treatment of Carcinoma of the Cervix Uteri

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