The compliance of renal transplant recipients with advice about sun protection measures

Seukeran, D.C.; Newstead, Chas; Cunliffe, W.J.

doi:10.1046/j.1365-2133.1998.02079.x

Cited by 82 publications

(71 citation statements)

References 10 publications

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“…Most transplant recipients are adults when they receive their new organs, and have accumulated years of sunlight-related skin damage. Although some patients modify their behavior to use sunscreen and stay out of the sun, most do not (62)(63)(64). We therefore used the hairless mouse model of posttransplantation skin cancer to study the effects of specific immunosuppression regimes on UVB-induced inflammation and to mimic both previous and ongoing sun exposure of adult transplant patients.…”

Section: Duncan Et Almentioning

confidence: 99%

Clinically Relevant Immunosuppressants Influence UVB-Induced Tumor Size Through Effects on Inflammation and Angiogenesis

Duncan¹,

Wulff²,

Tober³

et al. 2007

American Journal of Transplantation

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Immunosuppressive therapies allow long-term patient and transplant survival, but are associated with increased development of UV-induced skin cancers, particularly squamous cell carcinomas. The mechanisms by which CsA, MMF, tacrolimus (TAC) or sirolimus (SRL), alone or in dual combinations, influence tumor development and progression are not completely understood. In the current study, chronically UV-exposed mice treated with SRL alone or in combination with CsA or TAC developed more tumors than mice treated with vehicle or other immunosuppressants, but the tumors were significantly smaller and less advanced. Mice treated with CsA or TAC developed significantly larger tumors than vehicle-treated mice, and a larger percentage in the CsA group were malignant. The addition of MMF to CsA, but not to TAC, significantly reduced tumor size. Immunosuppressant effects on UVB-induced inflammation and tumor angiogenesis may explain these findings. CsA enhanced both UVBinduced inflammation and tumor blood vessel density, while MMF reduced inflammation. Addition of MMF to CsA reduced tumor size and vascularity. SRL did not affect inflammation, but significantly reduced tumor vascularity. Thus the choice of immunosuppressants has important implications for tumor number, size and progression, likely due to the influence of immunosuppressants on UVB-induced inflammation and angiogenesis. † These authors contributed equally to this work.

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Section: Duncan Et Almentioning

confidence: 99%

Clinically Relevant Immunosuppressants Influence UVB-Induced Tumor Size Through Effects on Inflammation and Angiogenesis

Duncan¹,

Wulff²,

Tober³

et al. 2007

American Journal of Transplantation

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“…Transplant recipients who limit their exposure to ultraviolet radiation may reduce their risk of developing skin cancer. The data herein, together with recent reports by others, indicate the inadequate use of sun protection among transplant recipients (18)(19)(20). This is most concerning in those patients at greatest risk to develop skin cancer, including those with light skin, advanced age and those with a history of significant past sun exposure.…”

Section: Discussionmentioning

confidence: 86%

“…The similar patterns of sun protection use within the general population compared to the transplant population suggest that the majority of transplant patients do not appreciate the need for extra precautions to protect against UVR exposure (18,(21)(22)(23)29). This knowledge deficiency may persist because of a failure of information to be transferred from members of the transplant team to the patient.…”

Section: Discussionmentioning

confidence: 90%

“…This knowledge deficiency may persist because of a failure of information to be transferred from members of the transplant team to the patient. Seukeran and colleagues reported that less than onehalf of transplant patients were counseled on the need for sun protection at the time of transplant (18). Physicians within the transplant team have an important role in encouraging and supporting transplant patients to learn about sun protection and adopt changes in behavior.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Sun-Protective Practices of Organ Transplant Recipients

Donovan

Rosen

Shaw

2004

American Journal of Transplantation

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The incidence, morbidity and mortality of skin cancer are markedly increased in organ transplant recipients. Efforts aimed at reducing sun exposure through sun avoidance, sunscreens and sun-protective clothing are the most effective means to reduce the risk of skin cancer. We evaluated the sun-protective behaviors of 205 transplant recipients. Twenty-three percent of transplant patients continued to seek a tan. Thirty percent of patients did not use sunscreens, and of those patients who did, less than 5% were committed to using them daily. Thirty-seven percent of patients frequently wore hats and 39% of patients frequently wore additional clothing to block the sun. When data were stratified according to patient age, gender or skin phototype, we identified preferences for specific sun-protective methods. These data strongly suggest that many transplant recipients do not use adequate sun protection. Further study of strategies to encourage the use of sun protection among transplant patients is needed to reduce the incidence of skin cancer.

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“…The risk of metastasis is also high in skin cancers of these patients. 7,9,10 Drug-related lesions including hypertrichosis, gingival hyperplasia, acneiform fungal culture were done where indicated, after informed consent.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous manifestations in renal transplant recipients

2017

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Background: Skin lesions both benign and malignant occur frequently in renal transplant recipients receiving long term immunosuppressive drugs. Aim was to study cutaneous manifestations in renal transplant recipients (RTRs).Methods: Thirty two patients with chronic kidney diseases who underwent renal transplant were included in the study. All of the patients were fully examined for cutaneous, hair, nail and mucosal changes. Diagnostic measures such as scraping and biopsy of the lesions was carried out, where necessary.Results: Out of 32 patients, 23 (71.8%) were male and 9 (28.1%) were females. Skin infections occurred in 84.3% of the patients and most of them were fungal infections (37.5%), followed by viral infection in (31.2%) patients. Oral mucosal changes, hair and nail comprising of (34.3%), (71.8%), (43.7%) patients respectively. Only malignancy seen in one patient was basal cell carcinoma. Drug induced cutaneous manifestations were acneiform eruptions (18.75%), hirsutism (15.6%), hypertrichosis (9.3%), striae (6.25%), gingival hyperplasia (3.12%) and skin atrophy (3.12%).Conclusions: Skin lesions are a significant problem in renal transplant recipients. A careful monitoring of these patients is recommended for early diagnosis and treatment.

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The compliance of renal transplant recipients with advice about sun protection measures

Cited by 82 publications

References 10 publications

Clinically Relevant Immunosuppressants Influence UVB-Induced Tumor Size Through Effects on Inflammation and Angiogenesis

Clinically Relevant Immunosuppressants Influence UVB-Induced Tumor Size Through Effects on Inflammation and Angiogenesis

Evaluation of Sun-Protective Practices of Organ Transplant Recipients

Cutaneous manifestations in renal transplant recipients

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