The Complexity of Arterial Classical Monocyte Recruitment

Drechsler, Maik; Soehnlein, Oliver

doi:10.1159/000348795

Cited by 14 publications

(13 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, atherosclerosis is characterized by the adherence of circulating leukocytes to vascular endothelial cells and subsequently the migration of those cells to the subendothelial space (reviewed in ref. 93). In the sub-endothelial space macrophages, derived from newly recruited monocytes or local proliferation, remove modified lipoproteins to restore tissue functions.…”

Section: Anxa1 In Atherosclerosismentioning

confidence: 99%

The advantageous role of annexin A1 in cardiovascular disease

Jong

Leoni

Drechsler

et al. 2016

Cell Adhesion & Migration

Self Cite

View full text Add to dashboard Cite

The inflammatory response protects the human body against infection and injury. However, uncontrolled and unresolved inflammation can lead to tissue damage and chronic inflammatory diseases. Therefore, active resolution of inflammation is essential to restore tissue homeostasis. This review focuses on the pro-resolving molecule annexin A1 (ANXA1) and its derived peptides. Mechanisms instructed by ANXA1 are multidisciplinary and affect leukocytes as well as endothelial cells and tissue resident cells like macrophages and mast cells. ANXA1 has an outstanding role in limiting leukocyte recruitment and different aspects of ANXA1 as modulator of the leukocyte adhesion cascade are discussed here. Additionally, this review details the therapeutic relevance of ANXA1 and its derived peptides in cardiovascular diseases since atherosclerosis stands out as a chronic inflammatory disease with impaired resolution and continuous leukocyte recruitment.

show abstract

Section: Anxa1 In Atherosclerosismentioning

confidence: 99%

The advantageous role of annexin A1 in cardiovascular disease

Jong

Leoni

Drechsler

et al. 2016

Cell Adhesion & Migration

Self Cite

View full text Add to dashboard Cite

show abstract

“…40,41 On chemokine-triggered activation, leukocytes, specifically monocytes and lymphocytes, express β 2 -integrins and α 4 -integrins that have a high affinity to bind with intracellular adhesion molecule-1 and vascular-cell adhesion molecule-1, respectively, and as a result monocytes adhere to the arterial walls. 42 Driven by inflammatory markers, in particular cytokines and chemokines, such as macrophage colony-stimulating factor, IL-6, and MCP-1, these recruited monocytes differentiate into macrophages. 43,44 Lipid engulfment by macrophages then promotes further transformation to atherosclerotic foam cells.…”

Section: Monocyte Migration and Differentiation Of Macrophage And Foamentioning

confidence: 99%

HIV, Inflammation, and Calcium in Atherosclerosis

Shrestha

Irvin

Grünfeld

et al. 2014

ATVB

View full text Add to dashboard Cite

“…Several studies support the notion that adhesion molecules (e.g., P- and E-selectins, vascular cell adhesion molecule 1 (VCAM-1), and intercellular adhesion molecule 1 (ICAM-1)) play a role in the development of atherosclerosis; indeed, these molecules are expressed by endothelial cells lining atherosclerotic arteries in both humans and animals 20 21 22 . Recent studies also report VAP-1 expression in atherosclerotic lesions in humans and rabbits 6 7 .…”

Section: Discussionmentioning

confidence: 90%

Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques

Silvola

Virtanen

Siitonen

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Given the important role of inflammation and the potential association of the leukocyte trafficking-associated adhesion molecule vascular adhesion protein 1 (VAP-1) with atherosclerosis, this study examined whether functional VAP-1 is expressed in atherosclerotic lesions and, if so, whether it could be targeted by positron emission tomography (PET). First, immunohistochemistry revealed that VAP-1 localized to endothelial cells of intra-plaque neovessels in human carotid endarterectomy samples from patients with recent ischemic symptoms. In low-density lipoprotein receptor-deficient mice expressing only apolipoprotein B100 (LDLR−/−ApoB100/100), VAP-1 was expressed on endothelial cells lining inflamed atherosclerotic lesions; normal vessel walls in aortas of C57BL/6N control mice were VAP-1-negative. Second, we discovered that the focal uptake of VAP-1 targeting sialic acid-binding immunoglobulin-like lectin 9 based PET tracer [68Ga]DOTA-Siglec-9 in atherosclerotic plaques was associated with the density of activated macrophages (r = 0.58, P = 0.022). As a final point, we found that the inhibition of VAP-1 activity with small molecule LJP1586 decreased the density of macrophages in inflamed atherosclerotic plaques in mice. Our results suggest for the first time VAP-1 as a potential imaging target for inflamed atherosclerotic plaques, and corroborate VAP-1 inhibition as a therapeutic approach in the treatment of atherosclerosis.

show abstract

The Complexity of Arterial Classical Monocyte Recruitment

Cited by 14 publications

References 86 publications

The advantageous role of annexin A1 in cardiovascular disease

The advantageous role of annexin A1 in cardiovascular disease

HIV, Inflammation, and Calcium in Atherosclerosis

Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques

Contact Info

Product

Resources

About