The Complex Role of Personality in Cancer Treatment

Porcerelli, John H.; Bornstein, Robert F.; Porcerelli, Daniel J.; Arterbery, V. Elayne

doi:10.1097/nmd.0000000000000276

Cited by 21 publications

(8 citation statements)

References 31 publications

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“…These preliminary findings support the construct validity and clinical utility of trait dependency and detachment testing with oncology patients and suggest that detachment is associated with poorer quality of life and higher psychological distress, whereas dependency is associated with poorer doctor-patient relationships after a cancer diagnosis. 28 …”

Section: Associations Between Stress Cancer Risk and Cancer Outcomementioning

confidence: 99%

Cancer and Cancer-Related Fatigue and the Interrelationships With Depression, Stress, and Inflammation

Weber

O’Brien

2016

J Evid Based Complementary Altern Med

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Cancer-related fatigue (CRF) is a common symptom experienced in cancer patients. Depression, anxiety, and stress are associated with cancer. Depression and anxiety are also associated with CRF. At the cellular level, much is known about the impact of stress on the body generally, and its potential role in cancer. Stress, anxiety, and depression have been found to depress the immune system. Depression and stress have also been found to create inflammatory changes in the body and there is emerging evidence that inflammation is involved in cancer pathogenesis and in CRF. This article examines the relationships between stress, anxiety, depression, and cancer; relationships between anxiety and depression and CRF; and what happens at the cellular level, including impact on the immune system and emerging evidence of the role of inflammation in CRF. It also reports on research in relation to some Chinese herbal medicines that may be used to treat CRF.

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Section: Associations Between Stress Cancer Risk and Cancer Outcomementioning

confidence: 99%

Cancer and Cancer-Related Fatigue and the Interrelationships With Depression, Stress, and Inflammation

Weber

O’Brien

2016

J Evid Based Complementary Altern Med

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“…Psychological drug interventions include tricyclic antidepressants, benzodiazepine sedatives, and other nonmedication-based therapies. 7 Adjuvant drugs were added during the treatment of this patient based on his situation, but they failed to achieve the expected desirable effect. The intended analgesic effect was achieved by adjusting the OxyContin dose.…”

Section: Discussionmentioning

confidence: 99%

High-dose OxyContin to treat pain associated with bone metastasis in patients with small-cell lung cancer: a case study report

Zhou

Zhang

Dong

et al. 2016

DDDT

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Pain management is an important topic that has received extensive attention from clinical practitioners. Nearly all patients with malignant tumors suffer pain at the advanced stage of their disease. Oxycodone is a first-line choice for treating moderate-to-severe cancer-related pain, and OxyContin, a controlled-release oxycodone hydrochloride tablet, is internationally recognized as a safe and effective opioid analgesic. OxyContin has the characteristics of both immediate release and sustained release, with a time to onset and peak similar to those of immediate-release morphine. It acts on both μ and κ receptors and has been shown to be effective in treating different types of pain, especially neuropathic pain, theoretically without a dose cap. However, the dose is limited in clinical applications due to various factors that are likely to affect its analgesic effect and reduce patient quality of life. Cooperation with a patient’s family members is required during the treatment of cancer pain. Chronic cancer pain has a long disease course, which could easily cause complex psychological symptoms due to their important role in the pain experience. Pain is controllable, and patients have a right to not experience pain. An optimal living state can be achieved through collaboration between physicians and patients. Rational personalized treatment of cancer pain can improve patient quality of life, relieve pain, and help prolong patient survival. This article reports the treatment procedure and adverse reactions in a patient who was treated with high-dose OxyContin, with the aim of providing a reference for other clinical practitioners.

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“…An important implication of the findings summarized above is that βAR blockade should reduce the levels of VEGF, IL-1β, and RANKL produced by osteoblasts (and presumably osteocytes) in response to sympathetic activation, and thus offer some level of protection against bone metastatic events. It is important to emphasize that, in addition to a number of social stressors, the diagnosis of cancer and its treatment have a significant impact on the stress level of patients [44,[224][225][226][227][228]. β-blockers are used for the treatment of multiple conditions, including congestive heart failure, hypertension, migraines, infantile hemangioma, and thyrotoxicosis [229].…”

Section: Treatment Strategies To Limit Metastatic Cancer Cell Engraftment Into the Skeletonmentioning

confidence: 99%

Mechanisms Supporting the Use of Beta-Blockers for the Management of Breast Cancer Bone Metastasis

Madel

Elefteriou

2021

Cancers

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The skeleton is heavily innervated by sympathetic nerves and represents a common site for breast cancer metastases, the latter being the main cause of morbidity and mortality in breast cancer patients. Progression and recurrence of breast cancer, as well as decreased overall survival in breast cancer patients, are associated with chronic stress, a condition known to stimulate sympathetic nerve outflow. Preclinical studies have demonstrated that sympathetic stimulation of β-adrenergic receptors in osteoblasts increases bone vascular density, adhesion of metastatic cancer cells to blood vessels, and their colonization of the bone microenvironment, whereas β-blockade prevented these events in mice with high endogenous sympathetic activity. These findings in preclinical models, along with clinical data from breast cancer patients receiving β-blockers, support the pathophysiological role of excess sympathetic nervous system activity in the formation of bone metastases, and the potential of commonly used, safe, and low-cost β-blockers as adjuvant therapy to improve the prognosis of bone metastases.

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The Complex Role of Personality in Cancer Treatment

Cited by 21 publications

References 31 publications

Cancer and Cancer-Related Fatigue and the Interrelationships With Depression, Stress, and Inflammation

Cancer and Cancer-Related Fatigue and the Interrelationships With Depression, Stress, and Inflammation

High-dose OxyContin to treat pain associated with bone metastasis in patients with small-cell lung cancer: a case study report

Mechanisms Supporting the Use of Beta-Blockers for the Management of Breast Cancer Bone Metastasis

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