The Complex Action of Phosphonates as Antifungal Agents

Guest, David; Grant, Bruce

doi:10.1111/j.1469-185x.1991.tb01139.x

Cited by 333 publications

(324 citation statements)

References 118 publications

(72 reference statements)

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“…Moreover, our results show that CaPhi and KPhi completely inhibit F. solani spore germination but this effect was reversible after the 14-h incubation period. Consistent to our results, GUEST and GRANT (1991) reported that Phi cause disturbances at several metabolic sites in the mycelial phase, for example, inhibiting sporulation at low concentrations without affecting mycelial growth, and that, even at high concentrations, Phi are fungistatic rather than fungitoxic.…”

Section: Discussionsupporting

confidence: 80%

“…epa.gov/pesticides/biopesticides/). Pesticide properties of this compound were discovered by scientists at Rhône-Poulenc Agrochimie Laboratories in France during the 1970 s. Soon after, fosetyl-Al (aluminium tris O-ethyl phosphonate) was formulated under the trade name Aliette and released for commercial use (GUEST and GRANT 1991). Upon the expiration of the patent for the active ingredient in the fosetyl-Al, several formulations of phosphite biopesticides have become available in Argentina, United States, Brazil, Ecuador and Peru.…”

Section: Introductionmentioning

confidence: 99%

“…Direct effects on the oomycetes include: inhibition of mycelial growth, changes in the composition of the mycelium surface, increased activity of the pentose phosphate pathway, changes in the metabolism of pyrophosphate and inhibition of enzymes allosterically regulated by phosphate (GUEST and BOMPEIX 1990;GUEST and GRANT 1991;NIERE et al 1994;STEHMANN and GRANT 2000). Sporulation and germination of Phytophthora species have also been shown to be suppressed by these biopesticides (COHEN and COFFEY 1986;GARBELOTTO et al 2009).…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial activity of phosphites against different potato pathogens

et al. 2010

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Phosphites have low-toxicity on the environment and show high efficacy in controlling oomycete diseases in plants, both by a direct and an indirect mechanism. We have shown that they are also effective in reducing disease symptoms produced by Phytophthora infestans, Fusarium solani and Rhizoctonia solani when applied to potato seed tubers. To gain better insight into the direct mode of action of phosphites on different potato pathogens, and to ascertain chemical determinants in their direct antimicrobial activity, four potato pathogens were assayed with respect to sensitivity toward calcium, potassium and copper phosphites (CaPhi, KPhi and CuPhi, respectively). The influence of acidification and ionic strength changes after Phi addition on the antimicrobial activity, and the fungicidal or fungistatic activity, were evaluated. Results showed that phosphites were able to inhibit growth of all pathogens. Phytophthora infestans was the most inhibited pathogen by all phosphites, followed by Streptomyces scabies, while Rhizoctonia solani and Fusarium solani were less inhibited. CuPhi had the highest antimicrobial activity against the four pathogens analysed, and CaPhi and KPhi showed similar antimicrobial activities. Inhibitions by CuPhi and CaPhi could be partially explained by acidification of the media. However, results obtained with KPhi demonstrated that the phosphite anion has antimicrobial activity itself. The increase in ionic strength after Phi addition was not important in the antimicrobial activity of Phi. The activity of phosphites on germination of F. solani spores showed to be fungistatic rather than fungicidal.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antimicrobial activity of phosphites against different potato pathogens

et al. 2010

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“…Abdul Majeed et al (2010) synthesized a series of this compound and reported that these compounds have remarkable antimicrobial properties. Guest and Grant (1991) also reported the antifungal activity of its related compounds. The derivative of the common drug benzodiazepin was detected (2H-1,4-benzodiazepin-2-one,7chloro-1,3- This drug has significant antifungal and antimicrobial potential (Kumar and Joshi, 2008).…”

Section: Resultsmentioning

confidence: 99%

Management of Ascochyta rabiei by Chenopodium album Extracts

et al. 2016

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-Chenopodium album, leaves were selected to evaluate their antifungal potential against Ascochyta rabiei causative agent for chickpea blight. Different concentrations of methanolic extract of C. album leaves i.e. 1%, 2.5%, 4%, 5.5% and 7% were tested against the target fungus A. rabiei. Maximum reduction in the test fungal biomass (68%) was observed in 7% concentration. This methanolic leaf extract was partitioned and n-butanol, chloroform, n-hexane, ethyl acetate fractions were isolated according to their polarity. In vitro antifungal activity of these fractions was studied by serial dilution method. n-hexane fraction exhibited the highest antifungal potential with 55% inhibition in test fungal biomass, so this fraction was selected for Gas chromatography mass spectrometry (GC-MS) analysis. Total thirteen compounds identified in this analysis belonged to class aromatic hydrocarbons, hydrocarbons, saturated fatty acids, aromatic carboxylic acid, siloxanes, phosphonates and cardiac glycosides. These compounds might be responsible for antifungal activity of C. album.Keywords: antifungal potential, bathu, GC-MS, methanolic extract. RESUMO -Foram selecionadas folhas de Chenopodium album, para avaliação do potencial antifúngico contra o Ascochyta rabiei, agente causal da praga do grão de bico. Diferentes concentrações do extrato metanólico das folhas de C. album (1%, 2.5%, 4%, 5.5% e 7%) foram testadas contra o fungo-alvo

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“…Phosphite is thought to control disease symptoms and reduce 44 pathogenic lesions by stimulating the plant defense responses and/or directly inhibiting pathogen growth 45 Guest and Grant, 1991;Jackson et al, 2000). The precise mechanism remains 46 unknown, although it is thought likely that phosphite acts primarily by substituting for orthophosphate in 47 cell's phosphate cycle (Martin et al, 1989;Guest and Grant, 1991;Barchietto et al, 1992;Niere et al, 48 1994).…”

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confidence: 99%