The complete mechanism of an aldol condensation in water

Abstract

The base-catalyzed aldol condensation between benzaldehyde and p-acetylbenzoic acid in water shows an inverse solvent kinetic isotope effect, k3,D2O/k3,H2O, of 1.33±0.03. The reaction is definitely faster in D2O. This is...

Novel pyrazoline and pyrazole “turn on” fluorescent sensors selective for Zn2+/Cd2+ at λem 480 nm and Fe3+/Fe2+ at λem 465 nm in MeCN

“…2,6-Diacetylpyridine underwent Claisen–Schmidt condensation 26 with the required substituted aromatic aldehyde to afford the chalcone precursors 1–3 in acceptable yield (34–73%). After extensive investigation, it was discovered that a 2 : 1 ratio of ketone to aldehyde with catalytic amount of NaOH promoted formation of the required mono-chalcone and minimal formation of the bis-chalcone side product (ESI S3†).…”