The Complement System in Rheumatoid Synovitis. II. Intracytoplasmic Inclusions of Immunoglobulins and Complement

Britton, Melvin C.; Schur, Peter H.

doi:10.1002/art.1780140111

Cited by 68 publications

(22 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Elution of rheumatoid synovium using acid pH or high ionic-strength buffers has yielded predominantly IgG and albumin and C3 (21,22), and complexes rich in IgG and containing IgG and IgM rheumatoid factors have been identified. Striking diminution in CH50 (23)(24)(25) and C2 (26) has been recorded by both single radial diffusion and stoichiometric hemolytic titrations (27,28). Further evidence for the activation of late components including a reduction of C9 in seropositive patients has been noted more recently (29).…”

Section: Discussionmentioning

confidence: 89%

Synovial fluid lymphocytes in rheumatoid arthritis

Utsinger

1975

Arthritis & Rheumatism

View full text Add to dashboard Cite

There is significant evidence implicating immunologic mechanisms in the pathogenesis of rheumatoid arthritis (RA). To investigate the possibility that a cellular imbalance of T and B lymphocytes plays a role in perpetuating synovitis, an examination of the peripheral blood and synovial fluid lymphocytes of patients with seropositive rheumatoid arthritis was undertaken. A significant lymphopenia was encountered in RA patients, with values approximately midway between those in normal controls and the severe lymphopenia seen in a group of patients with systemic lupus erythematosus. A significantly greater diminution of T than B cells was noted in RA, and normal percentage distributions of lymphocytes in peripheral blood were documented. Normal percentages of T and B cells, similar to those in peripheral blood, were found in synovial fluids of patients with seropositive RA, seronegative RA, osteoarthritis, and gout. Two seropositive patients ex-

show abstract

Section: Discussionmentioning

confidence: 89%

Synovial fluid lymphocytes in rheumatoid arthritis

Utsinger

1975

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…C i . (11). Paired specimens of synovial fluid and venous blood were rapidly centrifuged, aliquoted, and stored at -i0" C until used.…”

Section: Methodsmentioning

confidence: 99%

The complement system in rheumatoid synovitis i. an analysis of complement component activities in rheumatoid synovial fluids

Ruddy

Austen

1970

Arthritis & Rheumatism

140

View full text Add to dashboard Cite

Stoichiometric hemolytic assays were used to measure the activities of the first four reacting cmponents of the complement sequence in synovial fluids from patients with seropositive or seronegative rheumatoid arthritis or degenerative joint disease. The pattern of component reductions in the seropositive rheumatoid arthritis fluids was consistent with activation of the complement system by an intra-articular immunologic process.

show abstract

“…In addition, the individual complement components (Cl through C3) are significantly lowered, and by-products of the complement sequence and active principals reflecting complement activation are found in synovial fluids (24). Leukotatic factors, consisting of C5-related products (28) and immune complexes (29,30), have also been identified in rheumatoid synovial fluids. Rheumatoid arthritis, therefore, represents at least in part an important example of an immunologic disease in which local activation of the complement system plays a pathogenetic role.…”

mentioning

confidence: 99%