The compensatory effect of regular exercise on long-term memory impairment in sleep deprived female rats

Salari, Masoumeh; Sheibani, Vahid; Saadati, Hakimeh; Pourrahimi, Ali Mohammad; Khaksari, Mohammad; Esmaeelpour, Khadijeh; Khodamoradi, Mehdi

doi:10.1016/j.beproc.2015.06.014

Cited by 41 publications

(24 citation statements)

References 52 publications

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“…The ability of mice to retain novel information and consolidate memory was interrupted by SD (40). Based on the results of previous studies, it seems that ovariectomized (OVX) female rats are more susceptible than intact animals to the harmful effects of SD on cognitive functions (6,13,18,19). Additionally, these finding are compatible with those of human studies indicating that menopausal females were susceptible to negative effects of sleep loss (41).…”

Section: Sleep Deprivation and Cognitive Disorderssupporting

confidence: 55%

“…Several documents indicate that physical exercise can compensate deteriorations associated with SD in short-and long-term memories in male (16,55) and female animals (6,19). These data suggest that the helpful effects of regular activity on cognitive deficits caused by SD may be mediated by BDNF and other signaling molecules in the hippocampus.…”

Section: Exercise Recovers Cognitive Impairments In the Sleep-deprivementioning

confidence: 92%

“…Several experiments established the significant correlation between REM sleep and cognitive performances in male and female animals. Animals that experienced SD indicated significant cognitive impairments in various paradigms such as radial ram water maze (16), Morris water maze (MWM) (6,17,19), and the plus-maze discriminative avoidance task (39). The negative effects of SD on emotional memory of mice were previously recognized (8).…”

Section: Sleep Deprivation and Cognitive Disordersmentioning

confidence: 99%

“…Other studies demonstrated that generation and preservation of long-term potentiating (LTP) and spatial learning and memory are impaired by sleep deprivation. Sleep deprivation also decreases trophic factors such as brain derived neurotrophic factors (BDNF) level in the hippocampus of male (16) and female (6,13,(17)(18)(19) rats.…”

Section: Introduction and Statement Of The Problemmentioning

confidence: 99%

“…Exercise can enhance cognitive performance and cell proliferation in the hippocampus (29). ments (6) and improve LTP (13) in neurodegenerative diseases and estrogen deprivation periods (31).Other investigations revealed that regular activity can prevent the SDinduced impairments of cognitive function, synaptic plasticity, and signaling molecules in the hippocampus of male (16) and female rats (6,13,18,19).…”

Section: Introduction and Statement Of The Problemmentioning

confidence: 99%

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A Review of Protective Effects of Exercise on Cognitive Impairments Induced by Sleep Deprivation in Female Rats

Saadati

2017

Arch Neurosci

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Sleep is an important factor in memory consolidation and brain health. In addition, sleep disorder is a common complaint among females in comparison with males. In menopausal females, to relieve sleep disturbances and other menopausal symptoms, hormone therapy may be used. Furthermore, although estrogen had helpful effects on the brain performance, hormone replacement therapy augmented unfavorable cardiovascular and oncological side effects. It is implied that exercise is a powerful nonpharmacological intervention that can develop the cognitive performances. The current study used the behavioral, physiological, and molecular evidence supporting these views.

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Section: Sleep Deprivation and Cognitive Disorderssupporting

confidence: 55%

Section: Exercise Recovers Cognitive Impairments In the Sleep-deprivementioning

confidence: 92%

Section: Sleep Deprivation and Cognitive Disordersmentioning

confidence: 99%

Section: Introduction and Statement Of The Problemmentioning

confidence: 99%

Section: Introduction and Statement Of The Problemmentioning

confidence: 99%

See 3 more Smart Citations

A Review of Protective Effects of Exercise on Cognitive Impairments Induced by Sleep Deprivation in Female Rats

Saadati

2017

Arch Neurosci

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Sex‐dependent effects of postweaning exposure to an enriched environment on novel objective recognition memory and anxiety‐like behaviors: The role of hippocampal BDNF level

Sakhaie

Sadegzadeh

Mohammadnia

et al. 2020

Intl J of Devlp Neuroscience

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Exposure to enriched environment (EE) has been indicated to enhance cognitive functions, hippocampal neural plasticity, neurogenesis, long‐term potentiation, and levels of the brain‐derived neurotrophic factor (BDNF) in laboratory animals. Also, studies on the sex‐dependent effects of exposure to EE during adolescence on adult cognitive functions are less. This is important because the beneficial effects of EE may be predominant in the adolescence stage. Therefore, the present study was designed to compare the effects of EE during adolescence (PND21‐PND60) on novel objective recognition memory (NORM), anxiety‐like behaviors, and hippocampal BDNF mRNA level in the adult male and female rats. Assessment of NORM and anxiety‐like behaviors has been done by novel objective recognition task, open field (OF), and elevated plus maze (EPM), respectively. The expression of BDNF mRNA level was also evaluated by quantitative RT‐PCR. Our findings demonstrated that housing in the EE during adolescence improves NORM in adult male rats. Also, exposure to EE during adolescence had a different effect on anxiety‐like behaviors in both sexes. Additionally, our results indicated an augmented BDNF level in the hippocampus of male and female rats. In conclusion, adolescent exposure to EE has sex‐dependent effects on cognitive functions and anxiety‐like behaviors and increases BDNF mRNA expression in the hippocampus of both male and female rats; thus, BDNF is an important factor that can mediate the beneficial effects of EE and running exercise on cognitive functions and psychiatric traits.

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Serotonin depletion during the postnatal developmental period causes behavioral and cognitive alterations and decreases BDNF level in the brain of rats

Saadati

Sadegzadeh

Sakhaie

et al. 2021

Intl J of Devlp Neuroscience

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A survey of the literature indicates that the developmental disruptions in serotonin (5‐HT) levels can influence the brain development and the function. To the best of our knowledge, so far, there are a few studies about the effects of developmental period 5‐HT depletion on cognition and behavior of adult male and female rats. Therefore, in the present study, we examined the effects of postnatal days (PND 10–20) administration of para‐chlorophenylalanine (PCPA, 100 mg/kg, s.c) a 5‐HT synthesis inhibitor, on anxiety‐related behaviors, pain sensitivity, short‐term recognition memory, and hippocampal and prefrontal cortex (PFC) brain‐derived neurotrophic factor (BDNF) mRNA expression in adult male and female rats. Novel object recognition memory (NORM) and behavioral parameters (anxiety‐like behaviors and pain sensitivity) were evaluated in early adulthood and after that, the hippocampi and PFC of the rat's brain were removed for the determination of BDNF mRNA expression. Our results indicated that the postnatal period administration of PCPA impaired short‐term NORM. The postnatal developmental period treatment with PCPA also increased anxiety‐like behaviors in the open field and elevated plus maze (EPM) tests. Postnatal PCPA treatment increased pain sensitivity in the hot plate test in both male and female rats, especially in female animals. In addition, postnatal days serotonin depletion decreased BDNF level in the hippocampus and PFC of both male and female rats. These findings demonstrate that serotonin plays the main role in neurodevelopment, cognitive functions, and behavior. Therefore, serotonergic system dysregulation during the developmental periods may have more adverse influences on the brain development of rats.

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The compensatory effect of regular exercise on long-term memory impairment in sleep deprived female rats

Cited by 41 publications

References 52 publications

A Review of Protective Effects of Exercise on Cognitive Impairments Induced by Sleep Deprivation in Female Rats

A Review of Protective Effects of Exercise on Cognitive Impairments Induced by Sleep Deprivation in Female Rats

Sex‐dependent effects of postweaning exposure to an enriched environment on novel objective recognition memory and anxiety‐like behaviors: The role of hippocampal BDNF level

Serotonin depletion during the postnatal developmental period causes behavioral and cognitive alterations and decreases BDNF level in the brain of rats

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