The compatibility polymorphism in invertebrate host/trematodes interactions: research of molecular determinants

Bouchut, Anne; Roger, Emmanuel; Gourbal, Benjamin; Grunau, Christoph; Coustau, Christine; Mitta, Guillaume

doi:10.1051/parasite/2008153304

Cited by 7 publications

(6 citation statements)

References 43 publications

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“…At present, however, there is relatively little empirical evidence demonstrating reciprocal molecular adaptations in both host and parasite. Here, we investigated the interaction between S. mansoni and the snail, B. glabrata, as this interaction is a popular model for the study of co-evolutionary dynamics Bouchut et al, 2008;Roger et al, 2008a;Roger et al, 2008b;Roger et al, 2008c;Steinauer, 2009). We confirmed that there are different levels of compatibility between two geographic strains of S. mansoni and their sympatric snail hosts, B. glabrata (Fig.…”

Section: Discussionmentioning

confidence: 99%

An example of molecular co-evolution: Reactive oxygen species (ROS) and ROS scavenger levels in Schistosoma mansoni/Biomphalaria glabrata interactions

Moné

Ribou

Cosseau

et al. 2011

International Journal for Parasitology

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Section: Discussionmentioning

confidence: 99%

An example of molecular co-evolution: Reactive oxygen species (ROS) and ROS scavenger levels in Schistosoma mansoni/Biomphalaria glabrata interactions

Moné

Ribou

Cosseau

et al. 2011

International Journal for Parasitology

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“…In this context, we have conducted in the last decade numerous studies on immunological interactions between the snail and the parasite [ 23 , 24 , 25 , 26 , 27 , 28 ]. We have demonstrated that the nature of the snail immune response depends on the strain/species of host or of parasite considered [ 23 , 24 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Experimental Infection of the Biomphalaria glabrata Vector Snail by Schistosoma mansoni Parasites Drives Snail Microbiota Dysbiosis

et al. 2021

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Host-parasite interaction can result in a strong alteration of the host-associated microbiota. This dysbiosis can affect the fitness of the host; can modify pathogen interaction and the outcome of diseases. Biomphalaria glabrata is the snail intermediate host of the trematode Schistosoma mansoni, the agent of human schistosomiasis, causing hundreds of thousands of deaths every year. Here, we present the first study of the snail bacterial microbiota in response to Schistosoma infection. We examined the interplay between B. glabrata, S. mansoni and host microbiota. Snails were infected and the microbiota composition was analysed by 16S rDNA amplicon sequencing approach. We demonstrated that the microbial composition of water did not affect the microbiota composition. Then, we characterised the Biomphalaria bacterial microbiota at the individual scale in both naive and infected snails. Sympatric and allopatric strains of parasites were used for infections and re-infections to analyse the modification or dysbiosis of snail microbiota in different host-parasite co-evolutionary contexts. Concomitantly, using RNAseq, we investigated the link between bacterial microbiota dysbiosis and snail anti-microbial peptide immune response. This work paves the way for a better understanding of snail/schistosome interaction and should have critical consequences in terms of snail control strategies for fighting schistosomiasis disease in the field.

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“…As such, many studies have been conducted on the immunobiological interactions between these two protagonists [30][31][32]. In this host-parasite interaction was defined the compatible/incompatible status of the so-called compatibility polymorphism [33][34][35][36] that resulted from the co-evolutionary arm race between host and parasite [37]. Compatibility polymorphism can be defined as follow: A specific B. glabrata strain harbors variable degrees of susceptibility toward different parasite strains, whereas a defined S. mansoni strain presents different levels of virulence/infectivity toward different B. glabrata strains.…”

Section: Introductionmentioning

confidence: 99%

A New Assessment of Thioester-Containing Proteins Diversity of the Freshwater Snail Biomphalaria glabrata

Duval

Pichon

Lassalle

et al. 2020

Genes

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Thioester-containing proteins (TEPs) superfamily is known to play important innate immune functions in a wide range of animal phyla. TEPs are involved in recognition, and in the direct or mediated killing of several invading organisms or pathogens. While several TEPs have been identified in many invertebrates, only one TEP (named BgTEP) has been previously characterized in the freshwater snail, Biomphalaria glabrata. As the presence of a single member of that family is particularly intriguing, transcriptomic data and the recently published genome were used to explore the presence of other BgTEP related genes in B. glabrata. Ten other TEP members have been reported and classified into different subfamilies: Three complement-like factors (BgC3-1 to BgC3-3), one α-2-macroblobulin (BgA2M), two macroglobulin complement-related proteins (BgMCR1, BgMCR2), one CD109 (BgCD109), and three insect TEP (BgTEP2 to BgTEP4) in addition to the previously characterized BgTEP that we renamed BgTEP1. This is the first report on such a level of TEP diversity and of the presence of macroglobulin complement-related proteins (MCR) in mollusks. Gene structure analysis revealed alternative splicing in the highly variable region of three members (BgA2M, BgCD109, and BgTEP2) with a particularly unexpected diversity for BgTEP2. Finally, different gene expression profiles tend to indicate specific functions for such novel family members.

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The compatibility polymorphism in invertebrate host/trematodes interactions: research of molecular determinants

Cited by 7 publications

References 43 publications

An example of molecular co-evolution: Reactive oxygen species (ROS) and ROS scavenger levels in Schistosoma mansoni/Biomphalaria glabrata interactions

An example of molecular co-evolution: Reactive oxygen species (ROS) and ROS scavenger levels in Schistosoma mansoni/Biomphalaria glabrata interactions

Experimental Infection of the Biomphalaria glabrata Vector Snail by Schistosoma mansoni Parasites Drives Snail Microbiota Dysbiosis

A New Assessment of Thioester-Containing Proteins Diversity of the Freshwater Snail Biomphalaria glabrata

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