The compass to follow: Focal adhesion turnover

Mavrakis, Manos; Juanes, M. Angeles

doi:10.1016/j.ceb.2023.102152

Cited by 15 publications

(12 citation statements)

References 79 publications

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“…Considering focal adhesions are closely related to the development of tumors ( 6 , 7 ), the role of the focal adhesion signaling pathway in LUSC remains to be further studied. The correlations between gene expression and immune score were analyzed using Spearman.…”

Section: Resultsmentioning

confidence: 99%

“…Many studies have proven that focal adhesion is closely related to immune activity in many cancers (6)(7)(8). First, the correlations between the expression of focal adhesion genes and immune score were analyzed using Spearman.…”

Section: Immune Activity Between Two Focal Adhesion-related Groups In...mentioning

confidence: 99%

“…Focal adhesions are the main connection between cells and the extracellular matrix and participate in cell movement and signal transduction ( 6 ). Among them, targeting molecules related to the focal adhesion pathway has become a potential therapeutic strategy for the treatment of tumors ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

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A novel gene signature related to focal adhesions for distinguishing and predicting the prognosis of lung squamous cell carcinoma

Hui,

Xie,

Niu

et al. 2024

Front. Med.

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BackgroundLung squamous cell carcinoma (LUSC) is a devastating and difficult-to-treat type of lung cancer, and the prognosis of LUSC is the worst. The functional roles of focal adhesion-related genes were explored in LUSC based on data from The Cancer Genome Atlas (TCGA).MethodsRNA sequencing data and clinical characteristics of LUSC patients in TCGA-LUSC were obtained from the TCGA database. Through systematic analysis, we screened the prognostic genes and determined the focal adhesion-related pathways closely associated with LUSC.ResultsWe identified 444 prognostic genes and focal adhesion-related pathways intimately associated with LUSC. According to the focal adhesion-related genes, TCGA-LUSC patients were well divided into two groups: the low-risk group (G1) and the high-risk group (G2). A differential expression analysis identified 44 differentially expressed genes (DEGs) upregulated in the low-risk G1 group and 379 DEGs upregulated in the high-risk G2 group. The upregulated DEGs in the G1 group were primarily related to tyrosine metabolism, steroid hormone biosynthesis, retinol metabolism, platinum drug resistance, pentose and glucuronate interconversions, and metabolism of xenobiotics by cytochrome P450, while the downregulated DEGs in the G1 group were primarily related to ECM-receptor interaction, focal adhesion, proteoglycans in cancer, small cell lung cancer, cytokine-cytokine receptor interaction, and TGF-beta signaling pathway. The immune activity of the G1 group was lower than that of the G2 group, and the half-maximal inhibitory concentration (IC50) of five chemotherapy drugs (i.e., gemcitabine, methotrexate, vinorelbine, paclitaxel, and cisplatin) was significantly different between the G1 and G2 groups. Furthermore, a 10-gene prognostic model was constructed to predict the prognosis for LUSC patients: ITGA3, VAV2, FLNC, FLT4, HGF, MYL2, ITGB1, PDGFRA, CCND2, and PPP1CB.ConclusionThe status of focal adhesion-related genes has a close relationship with tumor classification and immunity in LUSC patients. A novel focal adhesion-related signature had good prognostic and predictive performance for LUSC. Our findings may provide new insight into the diagnosis and treatment of LUSC.

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Section: Resultsmentioning

confidence: 99%

Section: Immune Activity Between Two Focal Adhesion-related Groups In...mentioning

confidence: 99%

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A novel gene signature related to focal adhesions for distinguishing and predicting the prognosis of lung squamous cell carcinoma

Hui,

Xie,

Niu

et al. 2024

Front. Med.

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“…At their surface, cells are anchored to the extracellular matrix (ECM) through focal adhesions (FAs), large integrin-containing protein complexes that link the intracellular actin cytoskeleton to the ECM ( Mavrakis and Juanes, 2023 ). FA proteins have been shown to be important for mechanosensing and transduction of shear stress ( Braddock et al, 1998 ; Shyy and Chien, 2002 ) ( Fig.…”

Section: Sensing Transduction and Subcellular Responses To Fluid Shea...mentioning

confidence: 99%

Response of cells and tissues to shear stress

Espina,

Cordeiro,

Milivojevic

et al. 2023

Journal of Cell Science

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Shear stress is essential for normal physiology and malignancy. Common physiological processes – such as blood flow, particle flow in the gut, or contact between migratory cell clusters and their substrate – produce shear stress that can have an impact on the behavior of different tissues. In addition, shear stress has roles in processes of biomedical interest, such as wound healing, cancer and fibrosis induced by soft implants. Thus, understanding how cells react and adapt to shear stress is important. In this Review, we discuss in vivo and in vitro data obtained from vascular and epithelial models; highlight the insights these have afforded regarding the general mechanisms through which cells sense, transduce and respond to shear stress at the cellular levels; and outline how the changes cells experience in response to shear stress impact tissue organization. Finally, we discuss the role of shear stress in collective cell migration, which is only starting to be appreciated. We review our current understanding of the effects of shear stress in the context of embryo development, cancer and fibrosis, and invite the scientific community to further investigate the role of shear stress in these scenarios.

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“…Therefore, the evidence revealed that timely FA turnover and directed cell migration depend on the interplay between many molecular factors beyond microtubules ( Mavrakis and Juanes, 2023 ).…”

Section: Adhesomes: a Growing List Of Proteins Participating In Adhes...mentioning

confidence: 99%

Thy-1 (CD90)-regulated cell adhesion and migration of mesenchymal cells: insights into adhesomes, mechanical forces, and signaling pathways

Valdivia,

Avalos,

Leyton

2023

Front. Cell Dev. Biol.

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Cell adhesion and migration depend on the assembly and disassembly of adhesive structures known as focal adhesions. Cells adhere to the extracellular matrix (ECM) and form these structures via receptors, such as integrins and syndecans, which initiate signal transduction pathways that bridge the ECM to the cytoskeleton, thus governing adhesion and migration processes. Integrins bind to the ECM and soluble or cell surface ligands to form integrin adhesion complexes (IAC), whose composition depends on the cellular context and cell type. Proteomic analyses of these IACs led to the curation of the term adhesome, which is a complex molecular network containing hundreds of proteins involved in signaling, adhesion, and cell movement. One of the hallmarks of these IACs is to sense mechanical cues that arise due to ECM rigidity, as well as the tension exerted by cell-cell interactions, and transduce this force by modifying the actin cytoskeleton to regulate cell migration. Among the integrin/syndecan cell surface ligands, we have described Thy-1 (CD90), a GPI-anchored protein that possesses binding domains for each of these receptors and, upon engaging them, stimulates cell adhesion and migration. In this review, we examine what is currently known about adhesomes, revise how mechanical forces have changed our view on the regulation of cell migration, and, in this context, discuss how we have contributed to the understanding of signaling mechanisms that control cell adhesion and migration.

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The compass to follow: Focal adhesion turnover

Cited by 15 publications

References 79 publications

A novel gene signature related to focal adhesions for distinguishing and predicting the prognosis of lung squamous cell carcinoma

A novel gene signature related to focal adhesions for distinguishing and predicting the prognosis of lung squamous cell carcinoma

Response of cells and tissues to shear stress

Thy-1 (CD90)-regulated cell adhesion and migration of mesenchymal cells: insights into adhesomes, mechanical forces, and signaling pathways

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