The comparison of the collagen fiber contents and hepatic stellate cell distribution in male and female chicken livers

Nishimura, Shigeyuki; Sagara, Ayano; Teshima, Akifumi; Shoji, Tetsuo

doi:10.1111/j.1740-0929.2011.00913.x

Cited by 2 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our previous study, the liver‐to‐body weight ratio was significantly higher in the pullets compared with that of cockerels. However, the percentage of collagen fiber to fresh tissue weight was higher in cockerels compared with that of pullets (Nishimura et al . 2011).…”

Section: Discussionmentioning

confidence: 99%

“…This sex‐dependent variation between the areas of HSCs corresponded to the occurrence of the collagen fiber content difference between sexes. It has been suggested that collagen fiber content relates to the proportion of HSC area in the liver tissue of the adult chicken (Nishimura et al . 2011) and the current study proposed that a sex‐dependent variation in collagen fiber content may occur at 8 weeks.…”

Section: Discussionmentioning

confidence: 99%

“…In the adult chicken liver, collagen fiber content differs between males and females. It has been suggested that this difference is due to the density and activity of hepatic stellate cells (HSCs) that are the major collagen-producing cells in the liver (Nishimura et al 2011). However, it is not known when or how this sex-dependent variation in collagen fiber contents occurs in the chicken liver.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Changes in collagen fiber content and hepatic stellate cell distribution in the liver of chick embryos and growing chickens

Nishimura¹,

Teshima

Chowdhury³

et al. 2011

Animal Science Journal

Self Cite

View full text Add to dashboard Cite

The content of collagen and the distribution of hepatic stellate cells (HSCs) were studied to elucidate the occurrence of sex-dependent variations in the liver of developing embryos and growing chickens. Chick embryos from embryonic days (e) 12 to e20 and chicks at 1, 4 and 8 weeks were analyzed. Liver tissue was processed using NaOH maceration and freeze-dried to obtain the collagen fiber specimens. HSCs were identified by double fluorescent immunohistochemistry for desmin and vimentin. There were no sex-dependent variations in the percentage of collagen fiber per liver weight and HSC area during embryonic stages. However, the content of collagen fiber increased during embryonic development in both sexes. On the other hand, the area of HSCs significantly increased in growing males but did not show any change in females. Importantly, sex differences were observed in both collagen fiber content and HSC area in the liver at 8 weeks. These results indicate that the occurrence of collagen content variations takes place at 8 weeks in chicken liver, suggesting that a sex-dependent hormone may play an important role on the collagen production of HSCs in the growing chicken liver.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Changes in collagen fiber content and hepatic stellate cell distribution in the liver of chick embryos and growing chickens

Nishimura¹,

Teshima

Chowdhury³

et al. 2011

Animal Science Journal

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our previous study indicated that the density of HSCs and the collagen fiber weight in the adult chicken liver are higher in males than in females (Nishimura et al . ), and these differences appear until 8 weeks of age (Nishimura et al . ).…”

Section: Introductionmentioning

confidence: 99%

Estradiol inhibits hepatic stellate cell area and collagen synthesis in the chicken liver

Nishimura

Teshima

Kawabata

et al. 2017

Animal Science Journal

Self Cite

View full text Add to dashboard Cite

Hepatic stellate cells (HSCs) are the main collagen-producing cells in the liver. The HSC area and amount of collagen fibers are different between male and female chickens. This study was performed to confirm the effect of estradiol on collagen synthesis in the growing chicken liver. Blood estradiol levels in chicks were compared at 4 and 8 weeks of age, and the collagen fibril network in liver tissue was observed at 8 weeks by scanning electron microscopy. Intraperitoneal administrations of estradiol and tamoxifen to male and female chicks, respectively, were performed daily from 5 to 8 weeks of age. The areas of HSCs and collagen contents were measured in the liver tissue. The blood estradiol level was higher in females than in males, and the collagen fibril network was denser in males than in females at 8 weeks of age. Estradiol administration in males induced decreases in the HSC area and collagen content of the liver. Conversely, tamoxifen administration in females induced an increase in the HSC area but did not facilitate collagen synthesis. Based on these results, estradiol inhibits the area and collagen synthesis of HSCs in the growing chicken liver under normal physiological conditions.

show abstract

The comparison of the collagen fiber contents and hepatic stellate cell distribution in male and female chicken livers

Cited by 2 publications

References 21 publications

Changes in collagen fiber content and hepatic stellate cell distribution in the liver of chick embryos and growing chickens

Changes in collagen fiber content and hepatic stellate cell distribution in the liver of chick embryos and growing chickens

Estradiol inhibits hepatic stellate cell area and collagen synthesis in the chicken liver

Contact Info

Product

Resources

About