The Comparison of the Adverse Events of Pentavalent Vaccine and DPT Vaccine in 2–6 Months Infants in Iran: A National Study

Khazaei, Zaher; Moradi, Ghobad; Zahraei, Seyed Mohsen; Gouya, Mohammad Mehdí; Goodarzi, Elham; Yaghini, Fateme; Roshani, Daem

doi:10.5334/aogh.2449

Cited by 2 publications

(3 citation statements)

References 16 publications

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“…Our study was conducted in Lorestan Province using data from the comprehensive urban/rural health centers, while their study was conducted in the city of Hamadan with AEFI data reported by the parents of children using a questionnaire. In the study by Khazaei et al [13], mild local reactions were the most prevalent AEFI with the pentavalent vaccine (31.68%), which is consistent with our study. In the study by Ekrami Noghabi et al [14], the most common systemic reaction after vaccination with the pentavalent vaccine was fever.…”

Section: Discussionsupporting

confidence: 93%

“…There was no evidence of convulsion or encephalopathy. Khazaei et al [ 13 ], in a 2013–2015 cross-sectional study comparing the adverse events of the pentavalent and DPT vaccines in healthy infants aged 2–6 months in Iran, found that the pentavalent vaccine had more recorded AEFIs than the DPT vaccine. High fever was most prevalent with the DPT vaccine (47.4%), while mild local reactions were most prevalent with the pentavalent vaccine (31.7%).…”

Section: Introductionmentioning

confidence: 99%

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Adverse Events Following Immunizations in Infants Under 1 Year of Age in Lorestan Province, Western Iran

Anbari

Koruosh

Alireza³

et al. 2023

J Prev Med Public Health

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Objectives: Vaccination is an important intervention for preventing disease and reducing disease severity. Universal vaccination programs have significantly reduced the incidence of many dangerous diseases among children worldwide. This study investigated the side effects after immunization in infants under 1 year of age in Lorestan Province, western Iran.Methods: This descriptive analytical study included data from all children <1 year old in Lorestan Province, Iran who were vaccinated according to the national schedule in 2020 and had an adverse event following immunization (AEFI). Data were extracted from 1084 forms on age, sex, birth weight, type of birth, AEFI type, vaccine type, and time of vaccination. Descriptive statistics (frequency, percentage) were calculated, and the chi-square test and Fisher exact test were used to assess differences in AEFIs according to the abovelisted variables.Results: The most frequent AEFIs were high fever (n=386, 35.6%), mild local reaction (n=341, 31.5%), and swelling and pain (n=121, 11.2%). The least common AEFIs were encephalitis (n=1, 0.1%), convulsion (n=2, 0.2%), and nodules (n=3, 0.3%). Girls and boys only showed significant differences in mild local reactions (p=0.044) and skin allergies (p=0.002). The incidence of lymphadenitis (p<0.001), severe local reaction (p<0.001), mild local reaction (p=0.007), fainting (p=0.032), swelling and pain (p=0.006), high fever (p=0.005), and nodules (p<0.001) showed significant differences based on age at vaccination.Conclusions: Immunization is a fundamental public health policy for controlling vaccine-preventable infectious diseases. Although vaccines such as the Bacillus Calmette-Guérin vaccine, oral poliovirus vaccine, and pentavalent vaccine are well-researched and reliable, AEFIs are inevitable.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Adverse Events Following Immunizations in Infants Under 1 Year of Age in Lorestan Province, Western Iran

Anbari

Koruosh

Alireza³

et al. 2023

J Prev Med Public Health

View full text Add to dashboard Cite

show abstract

“…This finding is not surprising since most of the respondents involved in this study received the pentavalent vaccine. Moreover, previous studies that compared the DPT vaccine and the pentavalent vaccine found fever to be the most common complication of the DPT vaccine, which is a component of the pentavalent vaccine [ 22 ]. Likewise, considering the antigenic nature of vaccines introduced into the body, the normal physiologic reaction of the body can cause fever due to the production of cytokines.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and patterns of adverse events following childhood immunization and the responses of mothers in Ile-Ife, South West Nigeria: a facility-based cross-sectional survey

Ogundele,

Fehintola,

Salami

et al. 2023

PHRP

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Objectives: This study aimed to examine the prevalence and pattern of adverse events following childhood immunization and the responses of mothers in Ile-Ife, South West Nigeria.Methods: This descriptive cross-sectional study was conducted among 422 mothers of children aged 0 to 24 months attending any of the 3 leading immunization clinics in Ile-Ife, Nigeria. The respondents were selected using the multi-stage sampling technique. Data were collected using a pretested structured interviewer-administered questionnaire and analyzed using IBM SPSS ver. 26.0. The chi-square test was used to test associations, while binary logistic regression was used to determine the predictors of mothers’ responses to adverse events following immunization (AEFIs). A p-value of <0.05 was considered statistically significant.Results: The mean age of the respondents was 29.99±5.74 years. About 38% of the children had experienced an AEFI. Most mothers believed that the pentavalent vaccine was the most common cause of AEFIs (67.5%). Fever (88.0%) and pain and swelling (76.0%) were the most common AEFIs. More than half of the mothers (53.7%) administered home treatment following an AEFI. Younger mothers (odds ratio [OR], 2.43; 95% confidence interval [CI], 1.20–5.01), mothers who delivered their children at a healthcare facility (OR, 3.24; 95% CI, 1.08–9.69), and mothers who were knowledgeable about reporting AEFIs (OR, 2.53; 95% CI, 1.04–7.70) were most likely to respond appropriately to AEFIs.Conclusion: The proportion of mothers who responded poorly to AEFIs experienced by their children was significant. Therefore, strategies should be implemented to improve mothers’ knowledge about AEFIs to improve their responses.

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The Comparison of the Adverse Events of Pentavalent Vaccine and DPT Vaccine in 2–6 Months Infants in Iran: A National Study

Cited by 2 publications

References 16 publications

Adverse Events Following Immunizations in Infants Under 1 Year of Age in Lorestan Province, Western Iran

Adverse Events Following Immunizations in Infants Under 1 Year of Age in Lorestan Province, Western Iran

Prevalence and patterns of adverse events following childhood immunization and the responses of mothers in Ile-Ife, South West Nigeria: a facility-based cross-sectional survey

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