<p>To investigate the numerical simulation for the nonlinear flexural behavior of pretensioned void slab beams, the three-dimensional finite element models (FEM) of the existing pretensioned void slabs were established and verified through tests. Firstly, based on the concrete constitutive laws in Chinese code and <i>EN 1992-1</i>, the damage factors in concrete damaged plasticity (CDP) models derived from energy equivalent model were incorporated. Meanwhile, the constitutive models of reinforcement and prestressing tendons were calibrated in accordance with the yield strength and tensile strength data obtained from the tests. Then, the flexural loading history of the beams were numerically analyzed, and the simulation outcomes were compared with the test results. Finally, the impact of constitutive laws and the damage factors on the calculation accuracy and efficiency of numerical simulation analysis were studied.</p>